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PRR5-ARHGAP8 PRR5-ARHGAP8 readthrough [ Homo sapiens (human) ]

Gene ID: 553158, updated on 6-Jul-2014
Official Symbol
PRR5-ARHGAP8provided by HGNC
Official Full Name
PRR5-ARHGAP8 readthroughprovided by HGNC
Primary source
HGNC:34512
See related
Ensembl:ENSG00000241484; Ensembl:ENSG00000248405; HPRD:18688; Vega:OTTHUMG00000160954
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The PRR5-ARHGAP8 mRNA is an infrequent but naturally occurring read-through transcript of the neighboring proline rich 5, renal (PRR5) and Rho GTPase activating protein 8 (ARHGAP8) genes. The resulting fusion protein contains sequence identity with each individual gene product, and it includes domains characteristic of a RhoGAP protein. The significance of this read-through transcript and the function of its protein product have not yet been determined. [provided by RefSeq, Nov 2010]
See PRR5-ARHGAP8 in Epigenomics, MapViewer
Location:
22q13
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 22 NC_000022.11 (44702502..44862784)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (45098382..45258664)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 229 Neighboring gene acidic (leucine-rich) nuclear phosphoprotein 32 family, member B pseudogene 2 Neighboring gene proline rich 5 (renal) Neighboring gene Rho GTPase activating protein 8 Neighboring gene PHD finger protein 21B Neighboring gene ribosomal protein L6 pseudogene 28 Neighboring gene uncharacterized LOC101927551

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
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NHGRI GWA Catalog
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
NHGRI GWA Catalog
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Preferred Names
PRR5-ARHGAP8 fusion protein
Names
PRR5-ARHGAP8 fusion protein
PRR5-ARHGAP8 fusion

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181334.4NP_851851.2  PRR5-ARHGAP8 fusion protein

    Status: REVIEWED

    Source sequence(s)
    AF195968, BI488517, Z83838
    Consensus CDS
    CCDS54538.1
    UniProtKB/TrEMBL
    F8W6F3
    Related
    ENSP00000374423, ENST00000389773
    Conserved Domains (3) summary
    pfam08539
    Location:2699
    Blast Score: 216
    HbrB; HbrB-like
    cd00170
    Location:134279
    Blast Score: 302
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    cl02570
    Location:313503
    Blast Score: 750
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000022.11 

    Range
    44702502..44862784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000154.1 

    Range
    28024497..28205949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018933.2 

    Range
    45057111..45217387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)