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    CHD3 chromodomain helicase DNA binding protein 3 [ Homo sapiens (human) ]

    Gene ID: 1107, updated on 14-Apr-2016
    Official Symbol
    CHD3provided by HGNC
    Official Full Name
    chromodomain helicase DNA binding protein 3provided by HGNC
    Primary source
    HGNC:HGNC:1918
    See related
    Ensembl:ENSG00000170004 HPRD:09071; MIM:602120; Vega:OTTHUMG00000150427
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZFH; Mi-2a; Mi2-ALPHA
    Summary
    This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    17p13.1
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (7884776..7912757)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7788096..7816075)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 88 Neighboring gene N(alpha)-acetyltransferase 38, NatC auxiliary subunit Neighboring gene cytochrome b5 domain containing 1 Neighboring gene small Cajal body-specific RNA 21 Neighboring gene uncharacterized LOC284023 Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Depletion of CHD3 results in derepression of latent HIV-1 LTR activity PubMed

    Go to the HIV-1, Human Interaction Database

    • , (from )
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    • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
      Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
    • Chromatin organization, organism-specific biosystem (from REACTOME)
      Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
    • Epigenetic regulation of gene expression, organism-specific biosystem (from REACTOME)
      Epigenetic regulation of gene expression, organism-specific biosystemEpigenetic processes regulate gene expression by modulating the frequency, rate, or extent of gene expression in a mitotically or meiotically heritable way that does not entail a change in the DNA se...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • HDACs deacetylate histones, organism-specific biosystem (from REACTOME)
      HDACs deacetylate histones, organism-specific biosystemLysine deacetylases (KDACs), historically referred to as histone deacetylases (HDACs), are divided into the Rpd3/Hda1 metal-dependent 'classical HDAC family' (de Ruijter et al. 2003, Verdin et al. 2...
    • Positive epigenetic regulation of rRNA expression, organism-specific biosystem (from REACTOME)
      Positive epigenetic regulation of rRNA expression, organism-specific biosystemTranscription of rRNA genes is controlled by epigenetic activation and repression (reviewed in Percipalle and Farrants 2006, McStay and Grummt 2008, Goodfellow and Zomerdijk 2012, Grummt and Langst 2...
    • RNA Polymerase I Promoter Clearance, organism-specific biosystem (from REACTOME)
      RNA Polymerase I Promoter Clearance, organism-specific biosystemPromoter clearance is one of the rate-limiting steps in Polymerase I transcription. This step is composed of three phases, promoter opening, transcription initiation and promoter escape.
    • RNA Polymerase I Transcription, organism-specific biosystem (from REACTOME)
      RNA Polymerase I Transcription, organism-specific biosystemThe rRNA genes are transcribed by RNA polymerase I, one of three eukaryotic nuclear RNA polymerases. The polymerase is a multisubunit complex, composed of two large subunits (the most conserved porti...
    • RNA Polymerase I Transcription Initiation, organism-specific biosystem (from REACTOME)
      RNA Polymerase I Transcription Initiation, organism-specific biosystemDuring initiation the double-stranded DNA must be melted and transcription begins. SL1 forms and interacts with UBF-1 and the rDNA promoter. It is this platform that will recruit active RNA polymeras...
    • RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, organism-specific biosystem (from REACTOME)
      RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, organism-specific biosystemTranscription by RNA Polymerase I, RNA Polymerase III and transcription from mitochondrial promoters.
    • Signaling events mediated by HDAC Class I, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class I, organism-specific biosystem
      Signaling events mediated by HDAC Class I
    • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation by TP53, organism-specific biosystemTP53 (p53) regulates transcription of a number of genes involved in cellular metabolism, survival, senescence and DNA damage response. For a recent review, please refer to Vousden and Prives 2009.
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent DNA helicase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    helicase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    histone deacetylase activity TAS
    Traceable Author Statement
    more info
     
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA duplex unwinding TAS
    Traceable Author Statement
    more info
    PubMed 
    centrosome organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin assembly or disassembly IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylation TAS
    Traceable Author Statement
    more info
     
    regulation of signal transduction by p53 class mediator TAS
    Traceable Author Statement
    more info
     
    regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    spindle organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    NuRD complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Preferred Names
    chromodomain-helicase-DNA-binding protein 3
    Names
    ATP-dependent helicase CHD3
    CHD-3
    hZFH
    mi-2 autoantigen 240 kDa protein
    zinc finger helicase
    zinc-finger helicase (Snf2-like)
    NP_001005271.2
    NP_001005273.1
    NP_005843.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005271.2NP_001005271.2  chromodomain-helicase-DNA-binding protein 3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and CDS, compared to variant 1, resulting in a longer protein (isoform 3) that has a distinct N-terminus, compared to isoform 1. The transcript is supported by ESTs and an mRNA but the predicted protein has not yet been confirmed experimentally.
      Source sequence(s)
      AF064844, AK125928, BC110648, BX283837, CB851648, U91543
      Consensus CDS
      CCDS32553.2
      UniProtKB/Swiss-Prot
      Q12873
      UniProtKB/TrEMBL
      B3KWV4, Q2TAZ1
      Related
      ENSP00000369716, OTTHUMP00000197337, ENST00000380358, OTTHUMT00000318052
      Conserved Domains (11) summary
      COG1111
      Location:9381317
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00024
      Location:687742
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:815973
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:11161241
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00176
      Location:7981094
      SNF2_N; SNF2 family N-terminal domain
      pfam06461
      Location:14391576
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13711416
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:206260
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17941966
      CHDCT2; CHDCT2 (NUC038) domain
      cd15531
      Location:440482
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:517559
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    2. NM_001005273.2NP_001005273.1  chromodomain-helicase-DNA-binding protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001005273.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variant 1 encodes isoform 1.
      Source sequence(s)
      AK125928, BC110648, CB851648, U91543
      Consensus CDS
      CCDS32554.1
      UniProtKB/Swiss-Prot
      Q12873
      UniProtKB/TrEMBL
      B3KWV4, Q2TAZ1
      Related
      ENSP00000332628, OTTHUMP00000197335, ENST00000330494, OTTHUMT00000318050
      Conserved Domains (11) summary
      COG1111
      Location:8791258
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00024
      Location:628683
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:756914
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:10571182
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00176
      Location:7391035
      SNF2_N; SNF2 family N-terminal domain
      pfam06461
      Location:13801517
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13121357
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:147201
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17351907
      CHDCT2; CHDCT2 (NUC038) domain
      cd15531
      Location:381423
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:458500
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    3. NM_005852.3NP_005843.2  chromodomain-helicase-DNA-binding protein 3 isoform 2

      See identical proteins and their annotated locations for NP_005843.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' CDS, compared to variant 1. The resulting protein (isoform 2) is shorter, compared to isoform 1.
      Source sequence(s)
      AK125928, BC110648, CB851648, U91543
      Consensus CDS
      CCDS32555.1
      UniProtKB/Swiss-Prot
      Q12873
      UniProtKB/TrEMBL
      B3KWV4, Q2TAZ1
      Related
      ENSP00000350907, OTTHUMP00000197336, ENST00000358181, OTTHUMT00000318051
      Conserved Domains (12) summary
      PHA03418
      Location:15191654
      PHA03418; hypothetical E4 protein; Provisional
      COG1111
      Location:8791258
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00024
      Location:628683
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:756914
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:10571182
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00176
      Location:7391035
      SNF2_N; SNF2 family N-terminal domain
      pfam06461
      Location:13801517
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13121357
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:147201
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17011873
      CHDCT2; CHDCT2 (NUC038) domain
      cd15531
      Location:381423
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:458500
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

      Range
      7884776..7912757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005256427.3XP_005256484.1  

      Conserved Domains (11) summary
      COG1111
      Location:9381317
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00024
      Location:687742
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:815973
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:11161241
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00176
      Location:7981094
      SNF2_N; SNF2 family N-terminal domain
      pfam06461
      Location:14391576
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13711416
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:206260
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17951923
      CHDCT2; CHDCT2 (NUC038) domain
      cd15531
      Location:440482
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:517559
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    2. XM_005256429.3XP_005256486.1  

      Conserved Domains (11) summary
      COG1111
      Location:9381317
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00024
      Location:687742
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:815973
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:11161241
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00176
      Location:7981094
      SNF2_N; SNF2 family N-terminal domain
      pfam06461
      Location:14391576
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13711416
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:206260
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17951967
      CHDCT2; CHDCT2 (NUC038) domain
      cd15531
      Location:440482
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:517559
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    3. XM_006721423.2XP_006721486.1  

      Conserved Domains (11) summary
      COG1111
      Location:9381317
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00024
      Location:687742
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:815973
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:11161241
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00176
      Location:7981094
      SNF2_N; SNF2 family N-terminal domain
      pfam06461
      Location:14391576
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13711416
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:206260
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17941922
      CHDCT2; CHDCT2 (NUC038) domain
      cd15531
      Location:440482
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:517559
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    4. XM_005256428.3XP_005256485.1  

      Conserved Domains (12) summary
      PHA03418
      Location:15781713
      PHA03418; hypothetical E4 protein; Provisional
      COG1111
      Location:9381317
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00024
      Location:687742
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:815973
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:11161241
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00176
      Location:7981094
      SNF2_N; SNF2 family N-terminal domain
      pfam06461
      Location:14391576
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13711416
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:206260
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17601888
      CHDCT2; CHDCT2 (NUC038) domain
      cd15531
      Location:440482
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:517559
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    5. XM_006721428.2XP_006721491.1  

      Conserved Domains (12) summary
      PHA03418
      Location:15781713
      PHA03418; hypothetical E4 protein; Provisional
      COG1111
      Location:9381317
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00024
      Location:687742
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:815973
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:11161241
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00176
      Location:7981094
      SNF2_N; SNF2 family N-terminal domain
      pfam06461
      Location:14391576
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13711416
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:206260
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17601932
      CHDCT2; CHDCT2 (NUC038) domain
      cd15531
      Location:440482
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:517559
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    6. XM_006721424.2XP_006721487.1  

      Conserved Domains (11) summary
      COG1111
      Location:9341313
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00024
      Location:683738
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:811969
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:11121237
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00176
      Location:7941090
      SNF2_N; SNF2 family N-terminal domain
      pfam06461
      Location:14351572
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13671412
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:206260
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17911919
      CHDCT2; CHDCT2 (NUC038) domain
      cd15531
      Location:436478
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:513555
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    7. XM_006721430.2XP_006721493.1  

      Conserved Domains (11) summary
      COG1111
      Location:9341313
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00024
      Location:683738
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:811969
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:11121237
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00176
      Location:7941090
      SNF2_N; SNF2 family N-terminal domain
      pfam06461
      Location:14351572
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13671412
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:206260
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17911963
      CHDCT2; CHDCT2 (NUC038) domain
      cd15531
      Location:436478
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:513555
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    8. XM_005256431.3XP_005256488.1  

      Conserved Domains (7) summary
      cd00024
      Location:687742
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:815973
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:11161184
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00176
      Location:7981094
      SNF2_N; SNF2 family N-terminal domain
      pfam08073
      Location:206260
      CHDNT; CHDNT (NUC034) domain
      cd15531
      Location:440482
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:517559
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    9. XM_006721425.2XP_006721488.2  

      See identical proteins and their annotated locations for XP_006721488.2

      Conserved Domains (11) summary
      COG1111
      Location:8481227
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00024
      Location:597652
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:725883
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:10261151
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00176
      Location:7081004
      SNF2_N; SNF2 family N-terminal domain
      pfam06461
      Location:13491486
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:12811326
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:116170
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17051833
      CHDCT2; CHDCT2 (NUC038) domain
      cd15531
      Location:350392
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:427469
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    10. XM_011523628.1XP_011521930.1  

      See identical proteins and their annotated locations for XP_011521930.1

      Conserved Domains (11) summary
      COG1111
      Location:8681247
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00024
      Location:617672
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:745903
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:10461171
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00176
      Location:7281024
      SNF2_N; SNF2 family N-terminal domain
      pfam06461
      Location:13691506
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13011346
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:136190
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17251853
      CHDCT2; CHDCT2 (NUC038) domain
      cd15531
      Location:370412
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:447489
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    11. XM_006721427.2XP_006721490.1  

      Conserved Domains (11) summary
      COG1111
      Location:8591238
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00024
      Location:608663
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:736894
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:10371162
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00176
      Location:7191015
      SNF2_N; SNF2 family N-terminal domain
      pfam06461
      Location:13601497
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:12921337
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:127181
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17161844
      CHDCT2; CHDCT2 (NUC038) domain
      cd15531
      Location:361403
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:438480
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    12. XM_011523629.1XP_011521931.1  

      See identical proteins and their annotated locations for XP_011521931.1

      Conserved Domains (11) summary
      COG1111
      Location:8681247
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00024
      Location:617672
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:745903
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:10461171
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00176
      Location:7281024
      SNF2_N; SNF2 family N-terminal domain
      pfam06461
      Location:13691506
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13011346
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:136190
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17251853
      CHDCT2; CHDCT2 (NUC038) domain
      cd15531
      Location:370412
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:447489
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    13. XM_011523630.1XP_011521932.1  

      See identical proteins and their annotated locations for XP_011521932.1

      Conserved Domains (11) summary
      COG1111
      Location:8481227
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00024
      Location:597652
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:725883
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:10261151
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00176
      Location:7081004
      SNF2_N; SNF2 family N-terminal domain
      pfam06461
      Location:13491486
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:12811326
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:116170
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17051833
      CHDCT2; CHDCT2 (NUC038) domain
      cd15531
      Location:350392
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:427469
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      7797025..7824854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)