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    CREM cAMP responsive element modulator [ Homo sapiens (human) ]

    Gene ID: 1390, updated on 22-Aug-2016
    Official Symbol
    CREMprovided by HGNC
    Official Full Name
    cAMP responsive element modulatorprovided by HGNC
    Primary source
    HGNC:HGNC:2352
    See related
    Ensembl:ENSG00000095794 HPRD:00444; MIM:123812; Vega:OTTHUMG00000017953
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ICER; CREM-2; hCREM-2
    Summary
    This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    10p11.21
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 10 NC_000010.11 (35126841..35212958)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (35415769..35501886)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376491 Neighboring gene cullin 2 Neighboring gene microRNA 3611 Neighboring gene RNA, U7 small nuclear 77 pseudogene Neighboring gene ATPase H+ transporting V1 subunit G1 pseudogene 4 Neighboring gene uncharacterized LOC105376493 Neighboring gene RNA, U6 small nuclear 794, pseudogene Neighboring gene RNA, U6 small nuclear 1167, pseudogene Neighboring gene cyclin Y

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Treatment of dopaminergic rat PC12 cells with HIV-1 Tat downregulates the expression of tyrosine hydroxylase (TH) by upregulating the expression of the inducible cAMP early repressor which in turn abrogates the transcription activity of the TH promoter PubMed
    tat Extracellular HIV-1 Tat protein activates the inducible cAMP early repressor (ICER) in both the Jurkat cell line and primary peripheral blood mononuclear cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
      SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
    • Selenium Metabolism and Selenoproteins, organism-specific biosystem (from WikiPathways)
      Selenium Metabolism and Selenoproteins, organism-specific biosystem* Comments belonging to specific genes on the Selenoprotein pathway ** TRXND3 gene: Although the geneID is correct, the sequence of this gene was guessed by analogy. ** Cystathionine gamma-lyase is t...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC17881, MGC41893, MGC111110

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cAMP response element binding protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    core promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    circadian regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    glycosphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    retinoic acid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    cAMP-responsive element modulator
    Names
    CREM 2alpha-b protein
    CREM 2beta-a protein
    cAMP response element modulator
    inducible cAMP early repressor ICER

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029065.1 RefSeqGene

      Range
      4969..91086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267562.1NP_001254491.1  cAMP-responsive element modulator isoform 23

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23) has an alternate first exon, lacks the exon containing the translation start codon, and uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (23) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG573680, BI459432, DA756152
      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (1) summary
      cd14690
      Location:122176
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    2. NM_001267563.1NP_001254492.1  cAMP-responsive element modulator isoform 24

      See identical proteins and their annotated locations for NP_001254492.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24) has an alternate first exon and lacks three other exons compared to variant 1. The resulting isoform (24) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AL117336, AL157783, BC041810, CB996061, DA756152
      Conserved Domains (1) summary
      cd14690
      Location:59113
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    3. NM_001267564.1NP_001254493.1  cAMP-responsive element modulator isoform 25

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25) uses an alternate first exon in place of the first three exons and contains an alternate in-frame exon compared to variant 1. The resulting isoform (25) has a shorter and distinct N-terminus and contains an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AL117336, AY292864, BC041810, BU193626, CD358637
      Consensus CDS
      CCDS58074.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000379225, OTTHUMP00000216845, ENST00000395887, OTTHUMT00000357929
      Conserved Domains (2) summary
      cd14690
      Location:225279
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:3875
      pKID; pKID domain
    4. NM_001267565.1NP_001254494.1  cAMP-responsive element modulator isoform 26

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The resulting isoform (26) has distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      BU193626, BU570307, CK300763
      Conserved Domains (2) summary
      pfam02173
      Location:6683
      pKID; pKID domain
      pfam13900
      Location:3267
      GVQW; Putative domain of unknown function
    5. NM_001267566.1NP_001254495.1  cAMP-responsive element modulator isoform 27

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The resulting isoform (27) has distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      BP370901, BU570307, CK300763
      Conserved Domains (1) summary
      pfam02173
      Location:1350
      pKID; pKID domain
    6. NM_001267567.1NP_001254496.1  cAMP-responsive element modulator isoform 28

      Status: REVIEWED

      Description
      Transcript Variant: This variant (28) has an alternate first exon in place of the first five exons compared to variant 1. The resulting isoform (28) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL117336, BC041810, BG720999, BP370901
      Consensus CDS
      CCDS58075.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000418336, OTTHUMP00000216916, ENST00000463314, OTTHUMT00000358044
      Conserved Domains (1) summary
      cd14690
      Location:81135
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    7. NM_001267568.1NP_001254497.1  cAMP-responsive element modulator isoform 29

      Status: REVIEWED

      Description
      Transcript Variant: This variant (29) has an alternate exon in place of the first six exons and has an alternate last exon compared to variant 1. The resulting isoform (29) has shorter and distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AL117336, AW439476, CD639591, CD640977, D14826
    8. NM_001267569.1NP_001254498.1  cAMP-responsive element modulator isoform 30

      Status: REVIEWED

      Description
      Transcript Variant: This variant (30) has two alternate exons in place of the first six exons and has an alternate last exon compared to variant 1. The resulting isoform (30) has shorter and distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AL117336, AW439476, CD640977, D14826
      Conserved Domains (1) summary
      cl02338
      Location:665
      DUF2303; Uncharacterized conserved protein (DUF2303)
    9. NM_001267570.1NP_001254499.1  cAMP-responsive element modulator isoform 31

      Status: REVIEWED

      Description
      Transcript Variant: This variant (31) has two alternate exons in place of the first six exons compared to variant 1. The resulting isoform (31) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK289379, AL117336, BC041810, CD640465
      Consensus CDS
      CCDS58076.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000419810, OTTHUMP00000216917, ENST00000468236, OTTHUMT00000358045
      Conserved Domains (1) summary
      cd14690
      Location:68122
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    10. NM_001881.3NP_001872.3  cAMP-responsive element modulator isoform 2

      See identical proteins and their annotated locations for NP_001872.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. These differences cause translation initiation at a downstream ATG, and result in a shorter isoform (2, also known as b) with a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC017117, BC066342, DA756152
      Consensus CDS
      CCDS7184.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000363858, OTTHUMP00000019443, ENST00000374726, OTTHUMT00000047551
      Conserved Domains (1) summary
      pfam02173
      Location:5389
      pKID; pKID domain
    11. NM_181571.2NP_853549.1  cAMP-responsive element modulator isoform 1

      See identical proteins and their annotated locations for NP_853549.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). This isoform represents an activator tau2 isoform.
      Source sequence(s)
      AL117336, AL157783, BC041810, BI561543
      Consensus CDS
      CCDS7180.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000265372, OTTHUMP00000216727, ENST00000345491, OTTHUMT00000357708
      Conserved Domains (2) summary
      cd14690
      Location:243297
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:68105
      pKID; pKID domain
    12. NM_182717.1NP_874386.1  cAMP-responsive element modulator isoform 4

      See identical proteins and their annotated locations for NP_874386.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as ICER1 and hCREM 2alpha-a, uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (4, also known as d) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, AL157783, BC041810, D14825, D14826
      Consensus CDS
      CCDS7187.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000420681, OTTHUMP00000019446, ENST00000473940, OTTHUMT00000047554
      Conserved Domains (1) summary
      cd14690
      Location:64118
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    13. NM_182718.1NP_874387.1  cAMP-responsive element modulator isoform 5

      See identical proteins and their annotated locations for NP_874387.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), also known as ICER11 gamma and hCREM 2beta-b, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (5, also known as e) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, BC041810, CN367927, D14826
      Consensus CDS
      CCDS53519.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000417460, OTTHUMP00000216745, ENST00000488328, OTTHUMT00000357739
      Conserved Domains (1) summary
      cd14690
      Location:52106
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    14. NM_182719.1NP_874388.1  cAMP-responsive element modulator isoform 6

      See identical proteins and their annotated locations for NP_874388.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), also known as ICER11 and hCREM 2beta-a, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (6, also known as f) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, AL157783, BC041810, D14825, D14826
      Consensus CDS
      CCDS53517.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000417807, OTTHUMP00000216835, ENST00000487763, OTTHUMT00000357909
      Conserved Domains (1) summary
      cd14690
      Location:64118
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    15. NM_182720.1NP_874389.1  cAMP-responsive element modulator isoform 7

      See identical proteins and their annotated locations for NP_874389.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), also known as ICER1 gamma and hCREM 2alpha-b, uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (7, also known as g) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, BC041810, CN367927, D14826
      Consensus CDS
      CCDS53518.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000349387, OTTHUMP00000216746, ENST00000356917, OTTHUMT00000357740
      Conserved Domains (1) summary
      cd14690
      Location:52106
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    16. NM_182721.1NP_874390.1  cAMP-responsive element modulator isoform 8

      See identical proteins and their annotated locations for NP_874390.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (8, also known as h) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AK289379, AL117336, BC041810
      Consensus CDS
      CCDS7188.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000417562, OTTHUMP00000216750, ENST00000474931, OTTHUMT00000047562
      Conserved Domains (1) summary
      cd14690
      Location:56110
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    17. NM_182723.1NP_874392.1  cAMP-responsive element modulator isoform 10

      See identical proteins and their annotated locations for NP_874392.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (10, also known as j) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, BC041810, CD686814
      Consensus CDS
      CCDS53521.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000419075, OTTHUMP00000216748, ENST00000488741, OTTHUMT00000357742
      Conserved Domains (1) summary
      cd14690
      Location:46100
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    18. NM_182724.1NP_874393.1  cAMP-responsive element modulator isoform 11

      See identical proteins and their annotated locations for NP_874393.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (11, also known as k) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AK289379, AL117336, BC041810
      Consensus CDS
      CCDS53520.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000417327, OTTHUMP00000216749, ENST00000490511, OTTHUMT00000357743
      Conserved Domains (1) summary
      cd14690
      Location:56110
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    19. NM_182769.2NP_877570.1  cAMP-responsive element modulator isoform 13

      See identical proteins and their annotated locations for NP_877570.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), also known as CREM theta2-tau2-beta, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (13, also known as m) with a distinct N-terminus, compared to isoform 1. This isoform represents an activator isoform theta 2.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG719264, BP370901
      Consensus CDS
      CCDS7186.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000341875, OTTHUMP00000216785, ENST00000342105, OTTHUMT00000357799
      Conserved Domains (2) summary
      cd14690
      Location:188242
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:1350
      pKID; pKID domain
    20. NM_182770.2NP_877571.1  cAMP-responsive element modulator isoform 14

      See identical proteins and their annotated locations for NP_877571.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), also known as CREM theta2-beta, uses an alternative downstream promoter, differs in the 5' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter isoform (14, also known as n) with a distinct N-terminus, compared to isoform 1. This isoform represents a repressor isoform theta 2.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG719264, BP370901
      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (2) summary
      cd14690
      Location:125179
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:1350
      pKID; pKID domain
    21. NM_182771.1NP_877572.1  cAMP-responsive element modulator isoform 15

      See identical proteins and their annotated locations for NP_877572.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), also known as CREM theta1-tau2-beta, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (15, also known as o) with a distinct N-terminus, compared to isoform 1. This isoform represents an activator isoform theta 1.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG719264
      Consensus CDS
      CCDS7185.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000354593, OTTHUMP00000019448, ENST00000361599, OTTHUMT00000047558
      Conserved Domains (2) summary
      cd14690
      Location:213267
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:3875
      pKID; pKID domain
    22. NM_182772.1NP_877573.1  cAMP-responsive element modulator isoform 16

      See identical proteins and their annotated locations for NP_877573.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), also known as CREM theta1-beta, uses an alternative downstream promoter, differs in the 5' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter isoform (16, also known as p) with a distinct N-terminus, compared to isoform 1. This isoform represents a repressor isoform theta 1.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG719264
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000417165, OTTHUMP00000216838, ENST00000484283, OTTHUMT00000357922
      Conserved Domains (2) summary
      cd14690
      Location:150204
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:3875
      pKID; pKID domain
    23. NM_183011.1NP_898829.1  cAMP-responsive element modulator isoform 21

      See identical proteins and their annotated locations for NP_898829.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), also known as CREM 10, differs in the 5' UTR, 3' UTR, and contains an additional segment in the coding region, compared to variant 1. This results in a shorter isoform (21, also known as u) with a distinct C-terminus, compared to isoform 1. This isoform represents the tau2 activator isoform.
      Source sequence(s)
      AL117336, AL157783, BC041810, D14825
      Consensus CDS
      CCDS7181.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000337138, OTTHUMP00000246777, ENST00000337656, OTTHUMT00000414969
      Conserved Domains (2) summary
      cd14690
      Location:243297
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:68105
      pKID; pKID domain
    24. NM_183012.1NP_898830.1  cAMP-responsive element modulator isoform 20

      See identical proteins and their annotated locations for NP_898830.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), also known as CREM 22, differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (20, also known as t) with a distinct C-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
      Source sequence(s)
      AL117336, AL157783, BC041810, D14825
      Consensus CDS
      CCDS31181.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000363866, OTTHUMP00000246778, ENST00000374734, OTTHUMT00000414970
      Conserved Domains (2) summary
      cd14690
      Location:180234
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:68105
      pKID; pKID domain
    25. NM_183013.2NP_898831.1  cAMP-responsive element modulator isoform 19

      See identical proteins and their annotated locations for NP_898831.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), also known as hCREM type1 alpha, differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (19, also known as s) with a distinct C-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
      Source sequence(s)
      AL117336, AL157783, BC041810, D14825, DA756152
      Consensus CDS
      CCDS7182.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000346804, OTTHUMP00000019444, ENST00000354759, OTTHUMT00000047552
      Conserved Domains (2) summary
      cd14690
      Location:192246
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:68105
      pKID; pKID domain
    26. NM_183060.2NP_898883.1  cAMP-responsive element modulator isoform 22

      See identical proteins and their annotated locations for NP_898883.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22) differs in the 5' UTR and lacks an in-frame segment of the coding region, compared to variant 1. This variant uses a downstream start codon, compared to variant 1. The resulting isoform (22, also known as v) is shorter and has a shorter N-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
      Source sequence(s)
      AL117336, AL157783, AV707433, BC041810, BI561543
      Consensus CDS
      CCDS7183.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000363860, ENST00000374728
      Conserved Domains (2) summary
      cd14690
      Location:164218
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:5289
      pKID; pKID domain

    RNA

    1. NR_051971.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) has an alternate first exon in place of the first 6 exons and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. This variant is represented as non-coding because the predicted protein is shorter than 100 aa and there is no support for the existence of this protein.
      Source sequence(s)
      AK289379, AL117336, BC041810, CD686814
    2. NR_051972.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) has an alternate first exon in place of the first 6 exons compared to variant 1. This variant is represented as non-coding because the predicted protein is shorter than 100 aa and there is no support for the existence of this protein.
      Source sequence(s)
      AL117336, BC041810, CD686814, DT220562
    3. NR_051973.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) has an alternate first exon in place of the first 6 exons compared to variant 1. This variant is represented as non-coding because the predicted protein is shorter than 100 aa and there is no support for the existence of this protein.
      Source sequence(s)
      AA453346, AL117336, AL157783, BC041810, DA756152
    4. NR_051974.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) has an alternate first exon in place of the first two exons and lacks two other exons compared to variant 1. This variant is represented as non-coding because the predicted protein is shorter than 100 aa and there is no support for the existence of this protein.
      Source sequence(s)
      AL117336, AL157783, BC041810, CN367927, DA756152
    5. NR_051975.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (32) has an alternate first exon in place of the first two exons and lacks three other exons compared to variant 1. This variant is represented as non-coding because the predicted protein is shorter than 100 aa and there is no support for the existence of this protein.
      Source sequence(s)
      AL117336, AL157783, BC041810, DA756152, DR760671

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p7 Primary Assembly

      Range
      35126841..35212958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017015724.1XP_016871213.1  

    2. XM_017015728.1XP_016871217.1  

    3. XM_017015716.1XP_016871205.1  

    4. XM_017015723.1XP_016871212.1  

      Related
      ENSP00000363853, OTTHUMP00000216843, ENST00000374721, OTTHUMT00000357927
    5. XM_017015727.1XP_016871216.1  

      Conserved Domains (1) summary
      cd14690
      Location:122176
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    6. XM_017015737.1XP_016871226.1  

    7. XM_017015717.1XP_016871206.1  

    8. XM_017015729.1XP_016871218.1  

    9. XM_017015719.1XP_016871208.1  

    10. XM_017015721.1XP_016871210.1  

      Related
      ENSP00000419684, OTTHUMP00000216839, ENST00000463960, OTTHUMT00000357923
    11. XM_017015734.1XP_016871223.1  

    12. XM_006717379.3XP_006717442.1  

      See identical proteins and their annotated locations for XP_006717442.1

      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (2) summary
      cd14690
      Location:243297
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:68105
      pKID; pKID domain
    13. XM_017015736.1XP_016871225.1  

    14. XM_017015726.1XP_016871215.1  

    15. XM_017015733.1XP_016871222.1  

    16. XM_006717378.3XP_006717441.1  

      See identical proteins and their annotated locations for XP_006717441.1

      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (2) summary
      cd14690
      Location:243297
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:68105
      pKID; pKID domain
    17. XM_011519316.2XP_011517618.1  

      See identical proteins and their annotated locations for XP_011517618.1

      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000393538, OTTHUMP00000216822, ENST00000429130, OTTHUMT00000357873
      Conserved Domains (2) summary
      cd14690
      Location:304358
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:117154
      pKID; pKID domain
    18. XM_006717387.3XP_006717450.1  

      Conserved Domains (2) summary
      pfam02173
      Location:69105
      pKID; pKID domain
      cd14690
      Location:255309
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    19. XM_011519324.2XP_011517626.1  

      See identical proteins and their annotated locations for XP_011517626.1

      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000420511, OTTHUMP00000216840, ENST00000479070, OTTHUMT00000357924
      Conserved Domains (2) summary
      pfam02173
      Location:69105
      pKID; pKID domain
      cd14690
      Location:255309
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    20. XM_017015720.1XP_016871209.1  

    21. XM_006717383.3XP_006717446.1  

      See identical proteins and their annotated locations for XP_006717446.1

      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (2) summary
      cd14690
      Location:180234
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:68105
      pKID; pKID domain
    22. XM_006717382.3XP_006717445.1  

      See identical proteins and their annotated locations for XP_006717445.1

      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (2) summary
      pfam02173
      Location:69105
      pKID; pKID domain
      cd14690
      Location:180234
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    23. XM_017015722.1XP_016871211.1  

      Related
      ENSP00000345384, OTTHUMP00000019442, ENST00000348787, OTTHUMT00000047550
      Conserved Domains (2) summary
      cd14690
      Location:164218
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:5289
      pKID; pKID domain
    24. XM_017015718.1XP_016871207.1  

    25. XM_017015725.1XP_016871214.1  

    26. XM_017015735.1XP_016871224.1  

    27. XM_017015731.1XP_016871220.1  

    28. XM_017015732.1XP_016871221.1  

    29. XM_011519325.2XP_011517627.1  

      See identical proteins and their annotated locations for XP_011517627.1

      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (2) summary
      pfam02173
      Location:69105
      pKID; pKID domain
      cd14690
      Location:255309
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    30. XM_011519327.2XP_011517629.1  

      See identical proteins and their annotated locations for XP_011517629.1

      Conserved Domains (2) summary
      pfam02173
      Location:5389
      pKID; pKID domain
      cd14690
      Location:239293
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    31. XM_017015730.1XP_016871219.1  

    32. XM_011519331.2XP_011517633.1  

      Conserved Domains (1) summary
      cd14690
      Location:188242
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    33. XM_011519335.2XP_011517637.1  

      See identical proteins and their annotated locations for XP_011517637.1

      Conserved Domains (1) summary
      cd14690
      Location:93147
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    34. XM_011519330.2XP_011517632.1  

      Conserved Domains (2) summary
      pfam02173
      Location:1450
      pKID; pKID domain
      cd14690
      Location:200254
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    35. XM_011519332.2XP_011517634.1  

      Conserved Domains (1) summary
      cd14690
      Location:176230
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    36. XM_011519333.1XP_011517635.1  

      Conserved Domains (1) summary
      cd14690
      Location:134188
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      35416939..35502837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_182722.1: Suppressed sequence

      Description
      NM_182722.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    2. NM_182725.1: Suppressed sequence

      Description
      NM_182725.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    3. NM_182850.2: Suppressed sequence

      Description
      NM_182850.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    4. NM_182853.2: Suppressed sequence

      Description
      NM_182853.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.