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BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit [ Homo sapiens (human) ]

Gene ID: 2972, updated on 19-Jul-2014
Official Symbol
BRF1provided by HGNC
Official Full Name
BRF1, RNA polymerase III transcription initiation factor 90 kDa subunitprovided by HGNC
Primary source
HGNC:11551
See related
Ensembl:ENSG00000185024; HPRD:05361; MIM:604902; Vega:OTTHUMG00000029884
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRF; hBRF; BRF-1; GTF3B; TAF3C; TAF3B2; TF3B90; TAFIII90; TFIIIB90; HEL-S-76p
Summary
This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. [provided by RefSeq, Jun 2011]
See BRF1 in Epigenomics, MapViewer
Location:
14q
Exon count :
22
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 14 NC_000014.9 (105209286..105315577, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105675623..105781914, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene microRNA 6765 Neighboring gene jagged 2 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 14 Neighboring gene BTB (POZ) domain containing 6 Neighboring gene phosphofurin acidic cluster sorting protein 2 Neighboring gene ribosomal protein S20 pseudogene 33 Neighboring gene testis expressed 22

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
New gene functions in megakaryopoiesis and platelet formation.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
TBP-class protein binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
gene expression TAS
Traceable Author Statement
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
rRNA transcription TAS
Traceable Author Statement
more info
PubMed 
regulation of mRNA stability IEA
Inferred from Electronic Annotation
more info
 
tRNA transcription TAS
Traceable Author Statement
more info
PubMed 
transcription from RNA polymerase III promoter TAS
Traceable Author Statement
more info
 
transcription initiation from RNA polymerase III promoter TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription factor TFIIIB complex NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
transcription factor IIIB 90 kDa subunit
Names
transcription factor IIIB 90 kDa subunit
B - related factor 1
general transcription factor IIIB, 90kD subunit
TBP - associated factor, RNA polymerase III, 90kD
epididymis secretory sperm binding protein Li 76p
TATA box binding protein (TBP)-associated factor 3C
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB
TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029489.1 

    Range
    5001..111292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242786.1NP_001229715.1  transcription factor IIIB 90 kDa subunit isoform 4

    See proteins identical to NP_001229715.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant (1). The resulting isoform (4) is shorter at the N-terminus and contains an insert compared to isoform 1.
    Source sequence(s)
    AK294899, AL512355, BC071637
    Consensus CDS
    CCDS55951.1
    UniProtKB/Swiss-Prot
    Q92994
    Conserved Domains (3) summary
    COG1405
    Location:1151
    Blast Score: 408
    SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
    cd00043
    Location:66152
    Blast Score: 147
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    pfam07741
    Location:367453
    Blast Score: 291
    BRF1; Brf1-like TBP-binding domain
  2. NM_001242787.1NP_001229716.1  transcription factor IIIB 90 kDa subunit isoform 5

    See proteins identical to NP_001229716.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant (1). The resulting isoform (5) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK294899, AK295579, AL512355, BC071637
    Consensus CDS
    CCDS55950.1
    UniProtKB/Swiss-Prot
    Q92994
    Conserved Domains (3) summary
    COG1405
    Location:1151
    Blast Score: 407
    SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
    cd00043
    Location:66152
    Blast Score: 147
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    pfam07741
    Location:339431
    Blast Score: 312
    BRF1; Brf1-like TBP-binding domain
  3. NM_001242788.1NP_001229717.1  transcription factor IIIB 90 kDa subunit isoform 6

    See proteins identical to NP_001229717.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC016743, BC071637, BC086856, BX440529
    Consensus CDS
    CCDS55952.1
    UniProtKB/Swiss-Prot
    Q92994
    Related
    ENSP00000369269, OTTHUMP00000243596, ENST00000379937, OTTHUMT00000408726
    Conserved Domains (4) summary
    COG1405
    Location:4239
    Blast Score: 516
    SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
    cd00043
    Location:66143
    Blast Score: 150
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    pfam07741
    Location:427519
    Blast Score: 322
    BRF1; Brf1-like TBP-binding domain
    pfam08271
    Location:443
    Blast Score: 148
    TF_Zn_Ribbon; TFIIB zinc-binding
  4. NM_001242789.1NP_001229718.1  transcription factor IIIB 90 kDa subunit isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant (1). The resulting isoform 7 is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK096471, BC071637, BC086856
    Consensus CDS
    CCDS55949.1
    UniProtKB/Swiss-Prot
    Q92994
    Related
    ENSP00000389859, OTTHUMP00000243598, ENST00000446501, OTTHUMT00000408730
    Conserved Domains (1) summary
    pfam07741
    Location:216308
    Blast Score: 298
    BRF1; Brf1-like TBP-binding domain
  5. NM_001242790.1NP_001229719.1  transcription factor IIIB 90 kDa subunit isoform 8

    See proteins identical to NP_001229719.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (8) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC016743, BX440529, N91109
    Consensus CDS
    CCDS55953.1
    UniProtKB/Swiss-Prot
    Q92994
    UniProtKB/TrEMBL
    V9HVY2
    Related
    ENSP00000446707, OTTHUMP00000243607, ENST00000548421, OTTHUMT00000408744
    Conserved Domains (3) summary
    COG1405
    Location:4162
    Blast Score: 279
    SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
    cd00043
    Location:93160
    Blast Score: 152
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    pfam08271
    Location:443
    Blast Score: 141
    TF_Zn_Ribbon; TFIIB zinc-binding
  6. NM_001519.3NP_001510.2  transcription factor IIIB 90 kDa subunit isoform 1

    See proteins identical to NP_001510.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC016743, BC071637, BX440529, U75276
    Consensus CDS
    CCDS10001.1
    UniProtKB/Swiss-Prot
    Q92994
    Conserved Domains (4) summary
    COG1405
    Location:4266
    Blast Score: 550
    SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
    cd00043
    Location:93170
    Blast Score: 151
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    pfam07741
    Location:454546
    Blast Score: 323
    BRF1; Brf1-like TBP-binding domain
    pfam08271
    Location:443
    Blast Score: 149
    TF_Zn_Ribbon; TFIIB zinc-binding
  7. NM_145685.2NP_663718.1  transcription factor IIIB 90 kDa subunit isoform 3

    See proteins identical to NP_663718.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant (1). The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AJ297407, BC071637
    Consensus CDS
    CCDS42001.1
    UniProtKB/Swiss-Prot
    Q92994
    Related
    ENSP00000376340, OTTHUMP00000163910, ENST00000392557, OTTHUMT00000074550
    Conserved Domains (2) summary
    cd00043
    Location:263
    Blast Score: 123
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    pfam07741
    Location:250342
    Blast Score: 302
    BRF1; Brf1-like TBP-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000014.9 

    Range
    105209286..105315577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267561.2XP_005267618.1  

    Conserved Domains (4) summary
    COG1405
    Location:4266
    Blast Score: 550
    SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
    cd00043
    Location:93170
    Blast Score: 151
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    pfam07741
    Location:453545
    Blast Score: 324
    BRF1; Brf1-like TBP-binding domain
    pfam08271
    Location:443
    Blast Score: 149
    TF_Zn_Ribbon; TFIIB zinc-binding
  2. XM_006720122.1XP_006720185.1  

    Conserved Domains (3) summary
    COG1405
    Location:15102
    Blast Score: 243
    SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
    cd00043
    Location:18103
    Blast Score: 150
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    pfam07741
    Location:290382
    Blast Score: 304
    BRF1; Brf1-like TBP-binding domain
  3. XM_006720123.1XP_006720186.1  

    Conserved Domains (2) summary
    pfam07741
    Location:233325
    Blast Score: 299
    BRF1; Brf1-like TBP-binding domain
    cl00050
    Location:639
    Blast Score: 82
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
  4. XM_005267563.1XP_005267620.1  

    See proteins identical to XP_005267620.1

    UniProtKB/Swiss-Prot
    Q92994
    Conserved Domains (2) summary
    cd00043
    Location:263
    Blast Score: 123
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    pfam07741
    Location:250342
    Blast Score: 302
    BRF1; Brf1-like TBP-binding domain

Alternate HuRef

Genomic

  1. AC_000146.1 

    Range
    85867702..85977984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 

    Range
    105613624..105719675
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145696.1: Suppressed sequence

    Description
    NM_145696.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

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