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Gnb5 guanine nucleotide binding protein (G protein), beta 5 [ Mus musculus (house mouse) ]

Gene ID: 14697, updated on 24-Jan-2015
Official Symbol
Gnb5provided by MGI
Official Full Name
guanine nucleotide binding protein (G protein), beta 5provided by MGI
Primary source
MGI:MGI:101848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GBS; flr; Gbeta5
Orthologs
See Gnb5 in MapViewer
Location:
9 D; 9 42.3 cM
Exon count:
14
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 9 NC_000075.6 (75306288..75345923)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene myosin VA Neighboring gene branched chain ketoacid dehydrogenase E1, beta polypeptide pseudogene Neighboring gene predicted gene, 33750 Neighboring gene myosin VC Neighboring gene uncharacterized LOC102636700 Neighboring gene Bcl2-like 10 Neighboring gene zygote arrest 1-like pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G-protein gamma-subunit binding ISO
Inferred from Sequence Orthology
more info
 
GTPase activating protein binding ISO
Inferred from Sequence Orthology
more info
 
chaperone binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell body ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
photoreceptor inner segment IDA
Inferred from Direct Assay
more info
PubMed 
photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
guanine nucleotide-binding protein subunit beta-5
Names
guanine nucleotide-binding protein subunit beta-5
hug
flail
flailer
transducin beta chain 5
guanine nucleotide binding protein, beta 5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010313.2NP_034443.1  guanine nucleotide-binding protein subunit beta-5 isoform 1

    See proteins identical to NP_034443.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1; also known as Long, Beta-5L, Gbeta5L) encodes the longer isoform (1).
    Source sequence(s)
    AI323394, BX513135, BY607717, CK621143, U69145
    Consensus CDS
    CCDS40692.1
    UniProtKB/Swiss-Prot
    P62881
    Conserved Domains (2) summary
    COG2319
    Location:96394
    COG2319; FOG: WD40 repeat [General function prediction only]
    cd00200
    Location:98395
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_138719.5NP_619733.1  guanine nucleotide-binding protein subunit beta-5 isoform 2

    See proteins identical to NP_619733.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2; also known as Gbeta5S) differs in the 5' UTR compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC133947
    UniProtKB/Swiss-Prot
    P62881
    UniProtKB/TrEMBL
    Q3UG14
    Conserved Domains (2) summary
    COG2319
    Location:54352
    COG2319; FOG: WD40 repeat [General function prediction only]
    cd00200
    Location:56353
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_073186.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon structure and contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC133947

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000075.6 

    Range
    75306288..75345923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000031.1 

    Range
    72465062..72505297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)