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RNF14 ring finger protein 14 [ Homo sapiens (human) ]

Gene ID: 9604, updated on 26-Aug-2014
Official Symbol
RNF14provided by HGNC
Official Full Name
ring finger protein 14provided by HGNC
Primary source
HGNC:10058
Locus tag
HRIHFB2038
See related
Ensembl:ENSG00000013561; HPRD:05745; MIM:605675; Vega:OTTHUMG00000129660
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARA54; HFB30; TRIAD2; HRIHFB2038
Summary
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]
See RNF14 in Epigenomics, MapViewer
Location:
5q23.3-q31.1
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 5 NC_000005.10 (141966837..141990291)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (141346402..141369856)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene glycine cleavage system protein H (aminomethyl carrier) pseudogene Neighboring gene KIAA0141 Neighboring gene protocadherin 12 Neighboring gene glucosamine-6-phosphate deaminase 1 Neighboring gene mitochondrial ribosomal protein L11 pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ26004

Gene Ontology Provided by GOA

Function Evidence Code Pubs
androgen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
small conjugating protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
androgen receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IEP
Inferred from Expression Pattern
more info
PubMed 
regulation of androgen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
response to estradiol IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
E3 ubiquitin-protein ligase RNF14
Names
E3 ubiquitin-protein ligase RNF14
androgen receptor associated protein 54
androgen receptor-associated protein 54

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201365.1NP_001188294.1  E3 ubiquitin-protein ligase RNF14 isoform 1

    See proteins identical to NP_001188294.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
    Source sequence(s)
    AC005740, BC126185, BE042895, DC396586
    Consensus CDS
    CCDS4270.1
    UniProtKB/Swiss-Prot
    Q9UBS8
    Related
    ENSP00000378027, ENST00000394519
    Conserved Domains (4) summary
    smart00647
    Location:289350
    Blast Score: 154
    IBR; In Between Ring fingers
    pfam01485
    Location:377433
    Blast Score: 78
    IBR; IBR domain
    pfam05773
    Location:4133
    Blast Score: 170
    RWD; RWD domain
    pfam13639
    Location:220256
    Blast Score: 85
    zf-RING_2; Ring finger domain
  2. NM_004290.4NP_004281.1  E3 ubiquitin-protein ligase RNF14 isoform 1

    See proteins identical to NP_004281.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC005740, AF060544, BE042895, DC402536
    Consensus CDS
    CCDS4270.1
    UniProtKB/Swiss-Prot
    Q9UBS8
    Related
    ENSP00000378028, OTTHUMP00000160065, ENST00000394520, OTTHUMT00000251860
    Conserved Domains (4) summary
    smart00647
    Location:289350
    Blast Score: 154
    IBR; In Between Ring fingers
    pfam01485
    Location:377433
    Blast Score: 78
    IBR; IBR domain
    pfam05773
    Location:4133
    Blast Score: 170
    RWD; RWD domain
    pfam13639
    Location:220256
    Blast Score: 85
    zf-RING_2; Ring finger domain
  3. NM_183398.2NP_899645.1  E3 ubiquitin-protein ligase RNF14 isoform 2

    See proteins identical to NP_899645.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon compared to variant 1. The translation begins at a downstream start codon and results in an isoform (2) that has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC005740, AF060544, BE042895, DB456366, DC402536
    Consensus CDS
    CCDS4271.1
    UniProtKB/Swiss-Prot
    Q9UBS8
    Conserved Domains (2) summary
    smart00647
    Location:163224
    Blast Score: 146
    IBR; In Between Ring fingers
    pfam13639
    Location:94130
    Blast Score: 80
    zf-RING_2; Ring finger domain
  4. NM_183399.2NP_899646.1  E3 ubiquitin-protein ligase RNF14 isoform 1

    See proteins identical to NP_899646.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
    Source sequence(s)
    AC005740, AF060544, BE042895, DC396586
    Consensus CDS
    CCDS4270.1
    UniProtKB/Swiss-Prot
    Q9UBS8
    Related
    ENSP00000348462, ENST00000356143
    Conserved Domains (4) summary
    smart00647
    Location:289350
    Blast Score: 154
    IBR; In Between Ring fingers
    pfam01485
    Location:377433
    Blast Score: 78
    IBR; IBR domain
    pfam05773
    Location:4133
    Blast Score: 170
    RWD; RWD domain
    pfam13639
    Location:220256
    Blast Score: 85
    zf-RING_2; Ring finger domain
  5. NM_183400.2NP_899647.1  E3 ubiquitin-protein ligase RNF14 isoform 1

    See proteins identical to NP_899647.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks a segment within the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
    Source sequence(s)
    AC005740, AF060544, BE042895, DC402536
    Consensus CDS
    CCDS4270.1
    UniProtKB/Swiss-Prot
    Q9UBS8
    Related
    ENSP00000324956, ENST00000347642
    Conserved Domains (4) summary
    smart00647
    Location:289350
    Blast Score: 154
    IBR; In Between Ring fingers
    pfam01485
    Location:377433
    Blast Score: 78
    IBR; IBR domain
    pfam05773
    Location:4133
    Blast Score: 170
    RWD; RWD domain
    pfam13639
    Location:220256
    Blast Score: 85
    zf-RING_2; Ring finger domain
  6. NM_183401.2NP_899648.1  E3 ubiquitin-protein ligase RNF14 isoform 1

    See proteins identical to NP_899648.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
    Source sequence(s)
    AC005740, AF060544, BE042895, DC358984
    Consensus CDS
    CCDS4270.1
    UniProtKB/Swiss-Prot
    Q9UBS8
    Conserved Domains (4) summary
    smart00647
    Location:289350
    Blast Score: 154
    IBR; In Between Ring fingers
    pfam01485
    Location:377433
    Blast Score: 78
    IBR; IBR domain
    pfam05773
    Location:4133
    Blast Score: 170
    RWD; RWD domain
    pfam13639
    Location:220256
    Blast Score: 85
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000005.10 

    Range
    141966837..141990291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268540.1XP_005268597.1  

    See proteins identical to XP_005268597.1

    UniProtKB/Swiss-Prot
    Q9UBS8
    Conserved Domains (2) summary
    smart00647
    Location:163224
    Blast Score: 146
    IBR; In Between Ring fingers
    pfam13639
    Location:94130
    Blast Score: 80
    zf-RING_2; Ring finger domain
  2. XM_005268542.1XP_005268599.1  

    See proteins identical to XP_005268599.1

    UniProtKB/TrEMBL
    B7Z229
    Conserved Domains (3) summary
    smart00647
    Location:113174
    Blast Score: 153
    IBR; In Between Ring fingers
    pfam01485
    Location:201257
    Blast Score: 79
    IBR; IBR domain
    pfam05773
    Location:479
    Blast Score: 106
    RWD; RWD domain
  3. XM_005268541.1XP_005268598.1  

    See proteins identical to XP_005268598.1

    UniProtKB/Swiss-Prot
    Q9UBS8
    Related
    ENSP00000378022, OTTHUMP00000160066, ENST00000394514, OTTHUMT00000251861
    Conserved Domains (2) summary
    smart00647
    Location:163224
    Blast Score: 146
    IBR; In Between Ring fingers
    pfam13639
    Location:94130
    Blast Score: 80
    zf-RING_2; Ring finger domain
  4. XM_005268543.2XP_005268600.1  

    See proteins identical to XP_005268600.1

    UniProtKB/TrEMBL
    B7Z229
    Conserved Domains (3) summary
    smart00647
    Location:113174
    Blast Score: 153
    IBR; In Between Ring fingers
    pfam01485
    Location:201257
    Blast Score: 79
    IBR; IBR domain
    pfam05773
    Location:479
    Blast Score: 106
    RWD; RWD domain
  5. XM_005268539.1XP_005268596.1  

    See proteins identical to XP_005268596.1

    UniProtKB/Swiss-Prot
    Q9UBS8
    Conserved Domains (2) summary
    smart00647
    Location:163224
    Blast Score: 146
    IBR; In Between Ring fingers
    pfam13639
    Location:94130
    Blast Score: 80
    zf-RING_2; Ring finger domain
  6. XM_005268537.1XP_005268594.1  

    See proteins identical to XP_005268594.1

    UniProtKB/Swiss-Prot
    Q9UBS8
    Conserved Domains (4) summary
    smart00647
    Location:289350
    Blast Score: 154
    IBR; In Between Ring fingers
    pfam01485
    Location:377433
    Blast Score: 78
    IBR; IBR domain
    pfam05773
    Location:4133
    Blast Score: 170
    RWD; RWD domain
    pfam13639
    Location:220256
    Blast Score: 85
    zf-RING_2; Ring finger domain
  7. XM_005268536.1XP_005268593.1  

    See proteins identical to XP_005268593.1

    UniProtKB/Swiss-Prot
    Q9UBS8
    Conserved Domains (4) summary
    smart00647
    Location:289350
    Blast Score: 154
    IBR; In Between Ring fingers
    pfam01485
    Location:377433
    Blast Score: 78
    IBR; IBR domain
    pfam05773
    Location:4133
    Blast Score: 170
    RWD; RWD domain
    pfam13639
    Location:220256
    Blast Score: 85
    zf-RING_2; Ring finger domain
  8. XM_005268538.1XP_005268595.1  

    See proteins identical to XP_005268595.1

    UniProtKB/Swiss-Prot
    Q9UBS8
    Conserved Domains (4) summary
    smart00647
    Location:289350
    Blast Score: 154
    IBR; In Between Ring fingers
    pfam01485
    Location:377433
    Blast Score: 78
    IBR; IBR domain
    pfam05773
    Location:4133
    Blast Score: 170
    RWD; RWD domain
    pfam13639
    Location:220256
    Blast Score: 85
    zf-RING_2; Ring finger domain

Alternate HuRef

Genomic

  1. AC_000137.1 

    Range
    136489841..136513255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 

    Range
    140779739..140803246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)