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    KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 [ Homo sapiens (human) ]

    Gene ID: 3778, updated on 24-Aug-2015
    Official Symbol
    KCNMA1provided by HGNC
    Official Full Name
    potassium channel, calcium activated large conductance subfamily M alpha, member 1provided by HGNC
    Primary source
    HGNC:HGNC:6284
    See related
    Ensembl:ENSG00000156113; HPRD:15967; MIM:600150; Vega:OTTHUMG00000018543
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLO; BKTM; SLO1; MaxiK; SAKCA; mSLO1; KCa1.1; SLO-ALPHA; bA205K10.1
    Summary
    MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Orthologs
    See KCNMA1 in Epigenomics, MapViewer
    Location:
    10q22.3
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (76869601..77637819, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (78629359..79397577, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378364 Neighboring gene ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) pseudogene 8 Neighboring gene KCNMA1 antisense RNA 1 Neighboring gene uncharacterized LOC105378371 Neighboring gene KCNMA1 antisense RNA 2 Neighboring gene uncharacterized LOC105378370 Neighboring gene KCNMA1 antisense RNA 3 Neighboring gene uncharacterized LOC105378369 Neighboring gene uncharacterized LOC105378368 Neighboring gene RNA, 5S ribosomal pseudogene 321 Neighboring gene uncharacterized LOC105378372 Neighboring gene zinc finger protein 532 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Generalized epilepsy and paroxysmal dyskinesia
    MedGen: C1836173 OMIM: 609446 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
    NHGRI GWA Catalog
    Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
    NHGRI GWA Catalog
    Genome wide association study identifies KCNMA1 contributing to human obesity.
    NHGRI GWA Catalog
    Genome-wide association analyses identify variants in developmental genes associated with hypospadias.
    NHGRI GWA Catalog
    Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
    NHGRI GWA Catalog
    Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 from both CCR5- and CXCR4-tropic HIV-1 strains opens calcium-activated potassium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages; these signals are mediated by CCR5 and CXCR4 PubMed

    Go to the HIV-1, Human Interaction Database

    • Ca2+ activated K+ channels, organism-specific biosystem (from REACTOME)
      Ca2+ activated K+ channels, organism-specific biosystemCa2+ activated potassium channels are expressed in neuronal and non-neuronal tissue such as smooth muscle, epithelial cell and sensory cells. Ca2+ activated potassium channels are activated when the ...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Insulin secretion, organism-specific biosystem (from KEGG)
      Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • Nitric oxide stimulates guanylate cyclase, organism-specific biosystem (from REACTOME)
      Nitric oxide stimulates guanylate cyclase, organism-specific biosystemNitric Oxide (NO) inhibits smooth muscle cell proliferation and migration, oxidation of low-density lipoproteins, and platelet aggregation and adhesion. It can stimulate vasodilatation of the endothe...
    • Pancreatic secretion, organism-specific biosystem (from KEGG)
      Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Pancreatic secretion, conserved biosystem (from KEGG)
      Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Platelet homeostasis, organism-specific biosystem (from REACTOME)
      Platelet homeostasis, organism-specific biosystemUnder normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in charact...
    • Potassium Channels, organism-specific biosystem (from REACTOME)
      Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
    • Renin secretion, organism-specific biosystem (from KEGG)
      Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
    • Renin secretion, conserved biosystem (from KEGG)
      Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
    • Salivary secretion, organism-specific biosystem (from KEGG)
      Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
    • Salivary secretion, conserved biosystem (from KEGG)
      Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
    • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
      Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
      Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • cGMP effects, organism-specific biosystem (from REACTOME)
      cGMP effects, organism-specific biosystemCyclic guanosine monophosphate (cGMP) is an important secondary messenger synthesized by guanylate cyclases. cGMP has effects on phosphodiesterases (PDE), ion-gated channels, and the cGMP-dependent p...
    • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
      cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
      cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC71881, DKFZp686K1437

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium-activated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    large conductance calcium-activated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    large conductance calcium-activated potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    adult walking behavior IEA
    Inferred from Electronic Annotation
    more info
     
    auditory receptor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    blood coagulation TAS
    Traceable Author Statement
    more info
     
    cell maturation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular potassium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    eye blink reflex IEA
    Inferred from Electronic Annotation
    more info
     
    locomotor rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    micturition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell volume IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuromuscular process controlling balance IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal action potential IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of aldosterone metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    relaxation of vascular smooth muscle IEA
    Inferred from Electronic Annotation
    more info
     
    response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to carbon monoxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to carbon monoxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to osmotic stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    saliva secretion IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
     
    smooth muscle contraction involved in micturition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic transmission TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    terminal bouton IEA
    Inferred from Electronic Annotation
    more info
     
    voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    calcium-activated potassium channel subunit alpha-1; uncharacterized protein
    Names
    BK channel alpha subunit
    BKCA alpha subunit
    big potassium channel alpha subunit
    calcium-activated potassium channel, subfamily M subunit alpha-1
    hSlo
    k(VCA)alpha
    maxi-K channel HSLO
    potassium large conductance calcium-activated channel, subfamily M, alpha member 1
    slo homolog
    slowpoke homolog
    stretch-activated Kca channel

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012270.1 RefSeqGene

      Range
      5001..773219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014797.2NP_001014797.1  calcium-activated potassium channel subunit alpha-1 isoform a

      See identical proteins and their annotated locations for NP_001014797.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (a).
      Source sequence(s)
      AB209488, AC011439, BC024965, U09384
      UniProtKB/Swiss-Prot
      Q12791
      UniProtKB/TrEMBL
      Q59FH2
      Related
      ENSP00000473714, OTTHUMP00000272774, ENST00000604624, OTTHUMT00000468880
      Conserved Domains (4) summary
      pfam00520
      Location:216387
      Ion_trans; Ion transport protein
      pfam03493
      Location:536634
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306384
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. NM_001161352.1NP_001154824.1  calcium-activated potassium channel subunit alpha-1 isoform c

      See identical proteins and their annotated locations for NP_001154824.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (c) contains a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AB113382, AC011439, BC024965, BQ574058, U11058
      Consensus CDS
      CCDS60569.1
      UniProtKB/Swiss-Prot
      Q12791
      Related
      ENSP00000286628, OTTHUMP00000019912, ENST00000286628, OTTHUMT00000048885
      Conserved Domains (4) summary
      pfam00520
      Location:216387
      Ion_trans; Ion transport protein
      pfam03493
      Location:536634
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306384
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    3. NM_001161353.1NP_001154825.1  calcium-activated potassium channel subunit alpha-1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (d) contains a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AB113575, AC011439, BC024965, BQ574058, U11058
      Consensus CDS
      CCDS53545.1
      UniProtKB/Swiss-Prot
      Q12791
      Conserved Domains (4) summary
      pfam00520
      Location:216387
      Ion_trans; Ion transport protein
      pfam03493
      Location:536634
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306384
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    4. NM_001271518.1NP_001258447.1  calcium-activated potassium channel subunit alpha-1 isoform e

      See identical proteins and their annotated locations for NP_001258447.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) omits an in-frame coding exon. The resulting isoform (e) is shorter compared to isoform a.
      Source sequence(s)
      AB209488, AB524033, AC011439, BC024965, BC137115
      UniProtKB/TrEMBL
      D5MRH1
      UniProtKB/Swiss-Prot
      Q12791
      UniProtKB/TrEMBL
      Q59FH2
      Conserved Domains (4) summary
      pfam00520
      Location:162333
      Ion_trans; Ion transport protein
      pfam03493
      Location:482580
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:252330
      Ion_trans_2; Ion channel
      cl21454
      Location:356469
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    5. NM_001271519.1NP_001258448.1  calcium-activated potassium channel subunit alpha-1 isoform f

      See identical proteins and their annotated locations for NP_001258448.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (f) contains a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC011439, AC021032, AK024857, BC024965, BC144496
      UniProtKB/TrEMBL
      B7ZMF5
      Related
      ENSP00000385552, ENST00000406533
      Conserved Domains (4) summary
      pfam00520
      Location:216387
      Ion_trans; Ion transport protein
      pfam03493
      Location:536634
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306384
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    6. NM_001271520.1NP_001258449.1  uncharacterized protein isoform short1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) is a two-exon transcript with a distinct 3'UTR compared to variant 1. The predicted protein (short1) has a distinct C-terminus and is significantly shorter than isoform a. It is unknown if this protein is stable or has any function.
      Source sequence(s)
      AL731556, BC009695, BC024965
      Consensus CDS
      CCDS73156.1
      UniProtKB/TrEMBL
      A0A087WZL8
      Related
      ENSP00000482747, ENST00000618048
      Conserved Domains (1) summary
      cl00994
      Location:81134
      CcmE; CcmE
    7. NM_001271521.1NP_001258450.1  uncharacterized protein isoform short2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) is a two-exon transcript with a distinct 3'UTR compared to variant 1. The predicted protein (short2) has a distinct C-terminus and is significantly shorter than isoform a. It is unknown if this protein is stable or has any function.
      Source sequence(s)
      BC009695, BC024965
      Consensus CDS
      CCDS60572.1
      UniProtKB/TrEMBL
      S4R453
      Related
      ENSP00000475086, OTTHUMP00000272775, ENST00000481070, OTTHUMT00000048890
    8. NM_001271522.1NP_001258451.1  uncharacterized protein isoform short3

      See identical proteins and their annotated locations for NP_001258451.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) is a two-exon transcript with a distinct 3'UTR compared to variant 1. The predicted protein (short3) has a distinct C-terminus and is significantly shorter than isoform a. It is unknown if this protein is stable or has any function.
      Source sequence(s)
      BC024965
      Consensus CDS
      CCDS60571.1
      UniProtKB/Swiss-Prot
      Q12791
      Related
      ENSP00000474686, OTTHUMP00000272776, ENST00000480683, OTTHUMT00000048891
    9. NM_002247.3NP_002238.2  calcium-activated potassium channel subunit alpha-1 isoform b

      See identical proteins and their annotated locations for NP_002238.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (b) contains a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC011439, BC024965, BC137115, BQ574058, U11058, U13913
      Consensus CDS
      CCDS7352.1
      UniProtKB/Swiss-Prot
      Q12791
      Related
      ENSP00000286627, OTTHUMP00000019904, ENST00000286627, OTTHUMT00000048877
      Conserved Domains (4) summary
      pfam00520
      Location:216387
      Ion_trans; Ion transport protein
      pfam03493
      Location:536634
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306384
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

      Range
      76869601..77637819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005269797.1XP_005269854.1  

      UniProtKB/TrEMBL
      A0A0A0MRR0
      Conserved Domains (4) summary
      pfam00520
      Location:216387
      Ion_trans; Ion transport protein
      pfam03493
      Location:536634
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306384
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. XM_005269796.1XP_005269853.1  

      Conserved Domains (4) summary
      pfam00520
      Location:216387
      Ion_trans; Ion transport protein
      pfam03493
      Location:536634
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306384
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    3. XM_005269792.1XP_005269849.1  

      Conserved Domains (4) summary
      pfam00520
      Location:216387
      Ion_trans; Ion transport protein
      pfam03493
      Location:536634
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306384
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    4. XM_005269781.1XP_005269838.1  

      Conserved Domains (4) summary
      pfam00520
      Location:216387
      Ion_trans; Ion transport protein
      pfam03493
      Location:536634
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306384
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    5. XM_011539785.1XP_011538087.1  

      Conserved Domains (4) summary
      pfam00520
      Location:216387
      Ion_trans; Ion transport protein
      pfam03493
      Location:536634
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306384
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    6. XM_005269789.1XP_005269846.1  

      Conserved Domains (4) summary
      pfam00520
      Location:216387
      Ion_trans; Ion transport protein
      pfam03493
      Location:536634
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306384
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    7. XM_005269778.1XP_005269835.1  

      Conserved Domains (4) summary
      pfam00520
      Location:216387
      Ion_trans; Ion transport protein
      pfam03493
      Location:536634
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306384
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    8. XM_011539780.1XP_011538082.1  

      Conserved Domains (4) summary
      pfam00520
      Location:216387
      Ion_trans; Ion transport protein
      pfam03493
      Location:536634
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306384
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    9. XM_011539776.1XP_011538078.1  

      Conserved Domains (4) summary
      pfam00520
      Location:260431
      Ion_trans; Ion transport protein
      pfam03493
      Location:580678
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:350428
      Ion_trans_2; Ion channel
      cl21454
      Location:454567
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    10. XM_011539775.1XP_011538077.1  

      Conserved Domains (4) summary
      pfam00520
      Location:260431
      Ion_trans; Ion transport protein
      pfam03493
      Location:580678
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:350428
      Ion_trans_2; Ion channel
      cl21454
      Location:454567
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    11. XM_011539781.1XP_011538083.1  

      Conserved Domains (4) summary
      pfam00520
      Location:260431
      Ion_trans; Ion transport protein
      pfam03493
      Location:580678
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:350428
      Ion_trans_2; Ion channel
      cl21454
      Location:454567
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    12. XM_011539773.1XP_011538075.1  

      Conserved Domains (4) summary
      pfam00520
      Location:260431
      Ion_trans; Ion transport protein
      pfam03493
      Location:580678
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:350428
      Ion_trans_2; Ion channel
      cl21454
      Location:454567
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    13. XM_005269787.2XP_005269844.1  

      Related
      ENSP00000361485, OTTHUMP00000019908, ENST00000372408, OTTHUMT00000048881
      Conserved Domains (4) summary
      pfam00520
      Location:216387
      Ion_trans; Ion transport protein
      pfam03493
      Location:536634
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306384
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    14. XM_005269776.2XP_005269833.1  

      Related
      ENSP00000361520, OTTHUMP00000019913, ENST00000372443, OTTHUMT00000048886
      Conserved Domains (4) summary
      pfam00520
      Location:216387
      Ion_trans; Ion transport protein
      pfam03493
      Location:536634
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306384
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    15. XM_006717826.1XP_006717889.1  

      Conserved Domains (4) summary
      pfam00520
      Location:216387
      Ion_trans; Ion transport protein
      pfam03493
      Location:536634
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306384
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    16. XM_011539778.1XP_011538080.1  

      Conserved Domains (4) summary
      pfam00520
      Location:216387
      Ion_trans; Ion transport protein
      pfam03493
      Location:536634
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306384
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    17. XM_011539783.1XP_011538085.1  

      Related
      ENSP00000346321, ENST00000354353
      Conserved Domains (4) summary
      pfam00520
      Location:216387
      Ion_trans; Ion transport protein
      pfam03493
      Location:536634
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306384
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    18. XM_011539777.1XP_011538079.1  

      Conserved Domains (4) summary
      pfam00520
      Location:216387
      Ion_trans; Ion transport protein
      pfam03493
      Location:536634
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306384
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    19. XM_011539782.1XP_011538084.1  

      Conserved Domains (4) summary
      pfam00520
      Location:260431
      Ion_trans; Ion transport protein
      pfam03493
      Location:580678
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:350428
      Ion_trans_2; Ion channel
      cl21454
      Location:454567
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    20. XM_011539779.1XP_011538081.1  

      Conserved Domains (4) summary
      pfam00520
      Location:260431
      Ion_trans; Ion transport protein
      pfam03493
      Location:580678
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:350428
      Ion_trans_2; Ion channel
      cl21454
      Location:454567
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    21. XM_011539774.1XP_011538076.1  

      Conserved Domains (4) summary
      pfam00520
      Location:260431
      Ion_trans; Ion transport protein
      pfam03493
      Location:580678
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:350428
      Ion_trans_2; Ion channel
      cl21454
      Location:454567
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    22. XM_011539784.1XP_011538086.1  

      Conserved Domains (4) summary
      pfam00520
      Location:260431
      Ion_trans; Ion transport protein
      pfam03493
      Location:580678
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:350428
      Ion_trans_2; Ion channel
      cl21454
      Location:454567
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    23. XM_006717829.2XP_006717892.1  

      Conserved Domains (1) summary
      cl00994
      Location:81134
      CcmE; CcmE

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      78911952..79680009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)