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    scaf scarface [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35505, updated on 4-Apr-2024

    Summary

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    Official Symbol
    scafprovided by FlyBase
    Official Full Name
    scarfaceprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033033
    Locus tag
    Dmel_CG11066
    See related
    AllianceGenome:FB:FBgn0033033
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11066; CG15900; cSPH142; Dmel\CG11066; Scaf; scarf; SPH142
    Summary
    Involved in establishment or maintenance of epithelial cell apical/basal polarity; germ-band shortening; and morphogenesis of an epithelium. Located in cytoplasm and extracellular space. Colocalizes with apical plasma membrane and endosome. Is expressed in adult head; embryonic epidermis; embryonic/larval pericardial cell; extended germ band embryo; and ventral ectoderm. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See scaf in Genome Data Viewer
    Location:
    41F6-41F8; 2-55 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5676750..5691723, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1564255..1579228, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene kune-kune Neighboring gene Cytosolic non-specific dipeptidase 2 Neighboring gene vulcan

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sugar Promotes Feeding in Flies via the Serine Protease Homolog scarface. Prasad N, et al. Cell Rep, 2018 Sep 18. PMID 30232002, Free PMC Article
    2. The Serine Protease Homolog, Scarface, Is Sensitive to Nutrient Availability and Modulates the Development of the Drosophila Blood-Brain Barrier. Contreras EG, et al. J Neurosci, 2021 Jul 28. PMID 34210781, Free PMC Article
    3. Regulation of a serine protease homolog by the JNK pathway during thoracic development of Drosophila melanogaster. Srivastava A, et al. FEBS Open Bio, 2015. PMID 25737837, Free PMC Article
    4. The Drosophila serine protease homologue Scarface regulates JNK signalling in a negative-feedback loop during epithelial morphogenesis. Rousset R, et al. Development, 2010 Jul. PMID 20530545
    5. Scarface, a secreted serine protease-like protein, regulates polarized localization of laminin A at the basement membrane of the Drosophila embryo. Sorrosal G, et al. EMBO Rep, 2010 May. PMID 20379222, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Serine Protease Homolog, Scarface, Is Sensitive to Nutrient Availability and Modulates the Development of the Drosophila Blood-Brain Barrier.
      Title: The Serine Protease Homolog, Scarface, Is Sensitive to Nutrient Availability and Modulates the Development of the Drosophila Blood-Brain Barrier.
    2. scaf promotes feeding in response to the presence of sugar in the food, therefore providing a mechanism for the regulation of hedonic feeding.
      Title: Sugar Promotes Feeding in Flies via the Serine Protease Homolog scarface.
    3. Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr) pathway in the lateral epidermis for sustained dpp expression in the LE. Specifically, we demonstrate that Egfr pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling
      Title: Novel interplay between JNK and Egfr signaling in Drosophila dorsal closure.
    4. Scarface has a key role in regulating the polarized localization of laminin A in this developmental context.
      Title: Scarface, a secreted serine protease-like protein, regulates polarized localization of laminin A at the basement membrane of the Drosophila embryo.
    5. Results identify the serine protease homologue-encoding gene scaf as a new transcriptional target of JNK signalling and reveal the first secreted regulator of the JNK pathway acting in a negative-feedback loop during epithelial morphogenesis.
      Title: The Drosophila serine protease homologue Scarface regulates JNK signalling in a negative-feedback loop during epithelial morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c5678202-5678146 mobile_element_type = transposon:baggins{}5698
    • Loc: c5679027-5678594 mobile_element_type = transposon:INE-1{}5088

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    NOT enables serine-type endopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure, elongation of leading edge cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-band shortening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived male genitalia morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in notum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of developmental process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with recycling endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    scarface
    Names
    CG11066-PA
    CG11066-PB
    scaf-PA
    scaf-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      5676750..5691723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136336.3 → NP_610180.1  scarface, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610180.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K5M0
      Related
      FBpp0085396
      Conserved Domains (2) summary
      cd00190
      Location:428 → 616
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl28087
      Location:198 → 334
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

    2. NM_165441.2 → NP_724424.1  scarface, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724424.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K5M0
      Related
      FBpp0085397
      Conserved Domains (2) summary
      cd00190
      Location:428 → 616
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl28087
      Location:198 → 334
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K5M0.1 Q7K5M0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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