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    proA glutamate-5-semialdehyde dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946680, updated on 4-Apr-2024

    Summary

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    Gene symbol
    proA
    Gene description
    glutamate-5-semialdehyde dehydrogenase
    Primary source
    ASAP:ABE-0000832
    Locus tag
    b0243
    See related
    ECOCYC:EG10767
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0244; pro(1); pro1
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    Genomic context

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    Sequence:
    NC_000913.3 (261503..262756)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene outer membrane porin PhoE Neighboring gene glutamate 5-kinase Neighboring gene tRNA-Thr Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proline biosynthesis in Escherichia coli. Purification and characterisation of glutamate-semialdehyde dehydrogenase. Hayzer DJ, et al. Eur J Biochem, 1982 Jan. PMID 7035170
    2. Proline biosynthesis in Escherichia coli. Stoichiometry and end-product identification of the reaction catalysed by glutamate semialdehyde dehydrogenase. Hayzer DJ, et al. Biochem J, 1981 Aug 1. PMID 7034716, Free PMC Article
    3. Proline biosynthesis in Escherichia coli. Kinetic and mechanistic properties of glutamate semialdehyde dehydrogenase. Hayzer DJ, et al. Biochim Biophys Acta, 1983 Jan 26. PMID 6337636
    4. The biosynthesis of proline in Escherichia coli: phosphate-dependent glutamate -semialdehyde dehydrogenase (NADP), the second enzyme in the pathway. Baich A. Biochim Biophys Acta, 1971 Jul 20. PMID 4399189
    5. Structure and biosynthesis of unbranched multicopy single-stranded DNA by reverse transcriptase in a clinical Escherichia coli isolate. Lim D. Mol Microbiol, 1992 Dec. PMID 1282191

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A synonymous point mutation in the coding region of proB creates a new promoter for proA* and this mutation increases the level of ProA* by 2-fold but increases the growth rate by 5-fold.
      Title: A Synonymous Mutation Upstream of the Gene Encoding a Weak-Link Enzyme Causes an Ultrasensitive Response in Growth Rate.
    2. N-terminus verified by Edman degradation on complete protein
      Title: Analysis of the Escherichia coli proBA locus by DNA and protein sequencing.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate-5-semialdehyde dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate-5-semialdehyde dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate-5-semialdehyde dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-proline biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate-5-semialdehyde dehydrogenase
    NP_414778.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      261503..262756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414778.1 glutamate-5-semialdehyde dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414778.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376MRF9
      Conserved Domains (1) summary
      PRK00197
      Location:1 → 417
      proA; gamma-glutamyl phosphate reductase; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Other Literature Sources
    Molecular Biology Databases
    Research Materials