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    aroD 3-dehydroquinate dehydratase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946210, updated on 4-Apr-2024

    Summary

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    Gene symbol
    aroD
    Gene description
    3-dehydroquinate dehydratase
    Primary source
    ASAP:ABE-0005653
    Locus tag
    b1693
    See related
    ECOCYC:EG10076
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1691
    Summary
    Comparisons of the coli 3-dehydroquinase sequence and with the partial sequence of arom gene of aspergillus nidulans, which is known to include the 3-dehydroquinase domain, reveals significant homologies. [More information is available at EcoCyc: EG10076].
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    Genomic context

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    Sequence:
    NC_000913.3 (1774686..1775444)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transporter YdiN Neighboring gene quinate/shikimate dehydrogenase Neighboring gene putative acetate-CoA transferase YdiF Neighboring gene putative acyl-CoA dehydrogenase YdiO

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aromatic biosynthesis. XII. Conversion of 5-dehydroquinic acid to 5-dehydroshikimic acid dy 5-dehydroquinase. MITSUHASHI S, et al. Biochim Biophys Acta, 1954 Sep. PMID 13198937
    2. Mutagenesis of active site residues in type I dehydroquinase from Escherichia coli. Stalled catalysis in a histidine to alanine mutant. Leech AP, et al. J Biol Chem, 1995 Oct 27. PMID 7592767
    3. The cloning and analysis of the aroD gene of E. coli K-12. Kinghorn JR, et al. Gene, 1981 Jun-Jul. PMID 7021325
    4. Purification and characterization of 3-dehydroquinase from Escherichia coli. Chaudhuri S, et al. Biochem J, 1986 Nov 1. PMID 2950851, Free PMC Article
    5. Identification of the active-site lysine residues of two biosynthetic 3-dehydroquinases. Chaudhuri S, et al. Biochem J, 1991 Apr 1. PMID 1826831, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: The overexpression and complete amino acid sequence of Escherichia coli 3-dehydroquinase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-dehydroquinate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-dehydroquinate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-dehydroquinate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3,4-dihydroxybenzoate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 3,4-dihydroxybenzoate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 3,4-dihydroxybenzoate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aromatic amino acid family biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chorismate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-dehydroquinate dehydratase
    NP_416208.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1774686..1775444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416208.1 3-dehydroquinate dehydratase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416208.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      F4V2L9
      Conserved Domains (1) summary
      PRK02412
      Location:1 → 252
      aroD; type I 3-dehydroquinate dehydratase
    Nucleotide Protein
    Heading Accession and Version

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    Other Literature Sources
    Molecular Biology Databases
    Research Materials