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    add adenosine deaminase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945851, updated on 25-Jan-2024

    Summary

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    Gene symbol
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    Gene description
    adenosine deaminase
    Primary source
    ASAP:ABE-0005435
    Locus tag
    b1623
    See related
    ECOCYC:EG10030
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1618
    Summary
    Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG10030].
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    Genomic context

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    Sequence:
    NC_000913.3 (1702233..1703234)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene PTS enzyme IIBC component MalX Neighboring gene negative regulator of MalT activity/cystathionine beta-lyase Neighboring gene putative oxidoreductase YdgJ Neighboring gene beta-lactam resistance protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Investigation of various genotype characteristics for inosine accumulation in Escherichia coli W3110. Matsui H, et al. Biosci Biotechnol Biochem, 2001 Mar. PMID 11330670
    2. [Phenotypic manifestation of the pnd mutation, which promotes purine nucleoside cleavage by Escherichia coli K-12 cells, in the genome of strains defective in the metabolism of nucleic acid precursors]. Kocharian ShM, et al. Genetika, 1981. PMID 7014363
    3. Escherichia coli mutants with altered control of alcohol dehydrogenase and nitrate reductase. Clark D, et al. J Bacteriol, 1980 Jan. PMID 6986356, Free PMC Article
    4. Substrate binding by adenosine deaminase. Specificity, pH dependence, and competition by mercurials. Wolfenden R, et al. J Biol Chem, 1967 Mar 10. PMID 5335916
    5. Induction of adenosine deaminase in Escherichia coli. Remy CN, et al. J Bacteriol, 1968 Jul. PMID 4874315, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2'-deoxyadenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenosine deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenosine deaminase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in adenosine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within adenosine catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within hypoxanthine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in hypoxanthine salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hypoxanthine salvage IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in inosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine nucleotide interconversion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within purine nucleotide salvage IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in purine ribonucleoside monophosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine ribonucleoside monophosphate biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenosine deaminase
    NP_416140.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1702233..1703234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416140.1 adenosine deaminase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416140.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9B1B4, A0A8T3UKR8
      Conserved Domains (1) summary
      PRK09358
      Location:1 → 332
      PRK09358; adenosine deaminase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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