U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    rluC 23S rRNA pseudouridine(955/2504/2580) synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945637, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    rluC
    Gene description
    23S rRNA pseudouridine(955/2504/2580) synthase
    Primary source
    ASAP:ABE-0003675
    Locus tag
    b1086
    See related
    ECOCYC:EG11118
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1071; yceC
    Summary
    Ribosome-associated protein (Jiang, 2007). [More information is available at EcoGene: EG11118]. RluC catalyzes pseudouridylation of nucleotides U955, U2504, and U2580 in 23S rRNA; all three sites are located near the peptidyl transferase center of the ribosome . [More information is available at EcoCyc: EG11118].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (1144940..1145899)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ribonuclease E Neighboring gene DUF2655 domain-containing protein YceQ Neighboring gene m(7)GTP pyrophosphatase Neighboring gene ncRNA Neighboring gene DUF177 domain-containing protein YceD

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Suppression of DeltabipA phenotypes in Escherichia coli by abolishment of pseudouridylation at specific sites on the 23S rRNA. Krishnan K, et al. J Bacteriol, 2008 Dec. PMID 18820021, Free PMC Article
    2. Crystal structures of the catalytic domains of pseudouridine synthases RluC and RluD from Escherichia coli. Mizutani K, et al. Biochemistry, 2004 Apr 20. PMID 15078091
    3. Role of DNA supercoiling and rpoS sigma factor in the osmotic and growth phase-dependent induction of the gene osmE of Escherichia coli K12. Conter A, et al. J Mol Biol, 1997 Oct 17. PMID 9367747
    4. Analysis of the altered mRNA stability (ams) gene from Escherichia coli. Nucleotide sequence, transcriptional analysis, and homology of its product to MRP3, a mitochondrial ribosomal protein from Neurospora crassa. Claverie-Martin F, et al. J Biol Chem, 1991 Feb 15. PMID 1704367
    5. Crystallization and characterization of a fragment of pseudouridine synthase RluC from Escherichia coli. Corollo D, et al. Acta Crystallogr D Biol Crystallogr, 1999 Jan. PMID 10089432

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 23S rRNA pseudouridine(955/2504/2580) synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pseudouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA pseudouridine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA pseudouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in enzyme-directed rRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within enzyme-directed rRNA pseudouridine synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in enzyme-directed rRNA pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within enzyme-directed rRNA pseudouridine synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    23S rRNA pseudouridine(955/2504/2580) synthase
    NP_415604.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1144940..1145899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415604.1 23S rRNA pseudouridine(955/2504/2580) synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415604.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7D7EWV3
      Conserved Domains (1) summary
      PRK11025
      Location:1 → 319
      PRK11025; 23S rRNA pseudouridine(955/2504/2580) synthase RluC
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.