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    CAV1 caveolin 1 [ Homo sapiens (human) ]

    Gene ID: 857, updated on 12-May-2016
    Official Symbol
    CAV1provided by HGNC
    Official Full Name
    caveolin 1provided by HGNC
    Primary source
    HGNC:HGNC:1527
    See related
    Ensembl:ENSG00000105974 HPRD:03028; MIM:601047; Vega:OTTHUMG00000023413
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGL3; PPH3; BSCL3; LCCNS; VIP21; MSTP085
    Summary
    The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]
    Orthologs
    Location:
    7q31.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (116524785..116561185)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (116164839..116201239)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724434 Neighboring gene uncharacterized LOC105375463 Neighboring gene caveolin 2 Neighboring gene long intergenic non-protein coding RNA 1510 Neighboring gene MET proto-oncogene, receptor tyrosine kinase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Lipodystrophy with congenital cataracts and neurodegeneration
    MedGen: C1847582 OMIM: 606721 GeneReviews: Not available
    Compare labs
    Lipodystrophy, congenital generalized, type 3
    MedGen: C2675861 OMIM: 612526 GeneReviews: Not available
    Compare labs
    Primary pulmonary hypertension 3
    MedGen: C3809192 OMIM: 615343 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma.
    NHGRI GWA Catalog
    Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma.
    NHGRI GWA Catalog
    Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
    NHGRI GWA Catalog
    Genetic determinants of P wave duration and PR segment.
    NHGRI GWA Catalog
    Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.
    NHGRI GWA Catalog
    Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations.
    NHGRI GWA Catalog
    Genome-wide association study of PR interval.
    NHGRI GWA Catalog
    Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.
    NHGRI GWA Catalog
    Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
    NHGRI GWA Catalog
    Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.
    NHGRI GWA Catalog
    Several common variants modulate heart rate, PR interval and QRS duration.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of caveolin 1 (CAV1) by siRNA enhances HIV-1 infection in human Langerhans cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 forms a stable complex with caveolin-1 through its amino-acid residues 623-631 in HIV-infected cells; antibodies to the caveolin-1 binding domain in gp41 inhibit virus infectivity PubMed
    env Amino acid residues 61-101 of caveolin 1 are involved in the binding of caveolin 1 to the N36(L8)C34 domain of gp41 PubMed
    Nef nef Cav-1 physically interacts with HIV-1 Nef and restores Nef mediated impairment of apoA-I mediated cholesterol efflux in astrocyte derived glioblastoma cells and macrophages PubMed
    Tat tat HIV-1 Tat co-localizes with CAV1 in the cholesterol-enriched lipid rafts of human podocytes PubMed
    tat Activation of p38 MAPK in HIV-infected cells mediated by Tat leads to the phosphorylation of p53 which subsequently upregulates CAV-1 expression PubMed
    tat Treatment with Tat activates the Ras pathway in human brain micro vascular endothelial cells (HBMECs), an effect that is markedly attenuated by caveolin-1 silencing PubMed
    Vpr vpr HIV-1 Vpr C-terminus (residues 52-96) entry into cells is mediated through clathrin- and caveolae/raft-dependent endocytosis PubMed
    capsid gag HIV-1 CA co-localizes with langerin and caveolin-1 at the cell membrane of human Langerhans cells PubMed
    reverse transcriptase gag-pol CAV-1 expression inhibits HIV-1 replication monitored by reverse transcriptase activity PubMed

    Go to the HIV-1, Human Interaction Database

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    MDM2/MDM4 family protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase I transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Rac GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cholesterol binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    inward rectifier potassium channel inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ion channel binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nitric-oxide synthase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    patched binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    peptidase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding, bridging IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex scaffold TAS
    Traceable Author Statement
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural molecule activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    syntaxin binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    T cell costimulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    angiotensin-activated signaling pathway involved in heart process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    beta-catenin destruction complex disassembly TAS
    Traceable Author Statement
    more info
     
    calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    caveola assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    caveola assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    caveola assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    caveolin-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to exogenous dsRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to hyperoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to peptide hormone stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to starvation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to transforming growth factor beta stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular senescence IEA
    Inferred from Electronic Annotation
    more info
     
    cholesterol efflux IEA
    Inferred from Electronic Annotation
    more info
     
    cholesterol homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cholesterol homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    cholesterol transport TAS
    Traceable Author Statement
    more info
    PubMed 
    inactivation of MAPK activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lactation IEA
    Inferred from Electronic Annotation
    more info
     
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    lipid storage ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    maintenance of protein location in cell ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mammary gland development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mammary gland involution ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane depolarization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    microtubule polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of JAK-STAT cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of anoikis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cation channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of endothelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of necroptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of nitric oxide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of nitric-oxide synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of peptidyl-tyrosine autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of pinocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of potassium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of tyrosine phosphorylation of Stat5 protein IEA
    Inferred from Electronic Annotation
    more info
     
    nitric oxide homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    organ regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ER-associated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of calcium ion transport into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of catalytic activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell adhesion molecule production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gap junction assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of microtubule polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of toll-like receptor 3 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of vasoconstriction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    posttranscriptional regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    protein homooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein localization to basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein localization to plasma membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor internalization involved in canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    receptor-mediated endocytosis of virus by host cell IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cardiac muscle cell action potential involved in regulation of contraction IC
    Inferred by Curator
    more info
    PubMed 
    regulation of cell communication by electrical coupling involved in cardiac conduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of entry of bacterium into host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of heart rate by cardiac conduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of inward rectifier potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of membrane repolarization during action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of nitric-oxide synthase activity TAS
    Traceable Author Statement
    more info
     
    regulation of peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of ruffle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of smooth muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of the force of heart contraction by chemical signal IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ventricular cardiac muscle cell action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to estrogen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
     
    response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    response to progesterone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    skeletal muscle tissue development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    triglyceride metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    vasculogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    colocalizes_with VCP-NPL4-UFD1 AAA ATPase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basal plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    caveola NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    cilium IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    early endosome membrane TAS
    Traceable Author Statement
    more info
     
    endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid particle TAS
    Traceable Author Statement
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    caveolin-1
    Names
    caveolin 1, caveolae protein, 22kDa
    cell growth-inhibiting protein 32

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012051.1 RefSeqGene

      Range
      5001..41401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001172895.1NP_001166366.1  caveolin-1 isoform beta

      See identical proteins and their annotated locations for NP_001166366.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (beta) is shorter than isoform alpha. Variants 2, 3 and 4 encode the same isoform.
      Source sequence(s)
      AB209926, AC006159, AK290871, BC006432, BG170208, DB266251
      Consensus CDS
      CCDS55156.1
      UniProtKB/TrEMBL
      A0A024R757, Q2TNI1, Q59E85
      Related
      ENSP00000479447, ENST00000614113
      Conserved Domains (1) summary
      pfam01146
      Location:3146
      Caveolin; Caveolin
    2. NM_001172896.1NP_001166367.1  caveolin-1 isoform beta

      See identical proteins and their annotated locations for NP_001166367.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (beta) is shorter than isoform alpha. Variants 2, 3 and 4 encode the same isoform.
      Source sequence(s)
      AB209926, AC006159, AF172085, AK290871, BG170208, DA943080
      Consensus CDS
      CCDS55156.1
      UniProtKB/TrEMBL
      A0A024R757, Q2TNI1, Q59E85, Q7Z4F3
      Related
      ENSP00000377110, OTTHUMP00000195988, ENST00000393467, OTTHUMT00000141424
      Conserved Domains (1) summary
      pfam01146
      Location:3146
      Caveolin; Caveolin
    3. NM_001172897.1NP_001166368.1  caveolin-1 isoform beta

      See identical proteins and their annotated locations for NP_001166368.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (beta) is shorter than isoform alpha. Variants 2, 3 and 4 encode the same isoform.
      Source sequence(s)
      AB209926, AC006159, AK290871, BG170208, DA477166, EF649773
      Consensus CDS
      CCDS55156.1
      UniProtKB/TrEMBL
      A0A024R757, A9XTE5, Q2TNI1, Q59E85
      Related
      ENSP00000377111, OTTHUMP00000195989, ENST00000393468, OTTHUMT00000141425
      Conserved Domains (1) summary
      pfam01146
      Location:3146
      Caveolin; Caveolin
    4. NM_001753.4NP_001744.2  caveolin-1 isoform alpha

      See identical proteins and their annotated locations for NP_001744.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (alpha).
      Source sequence(s)
      AB209926, AC006159, AI878826, AK290871, BG170208
      Consensus CDS
      CCDS5767.1
      UniProtKB/Swiss-Prot
      Q03135
      UniProtKB/TrEMBL
      Q2TNI1, Q59E85
      Related
      ENSP00000339191, OTTHUMP00000025031, ENST00000341049, OTTHUMT00000059734
      Conserved Domains (1) summary
      pfam01146
      Location:34177
      Caveolin; Caveolin

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

      Range
      116524785..116561185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      116098482..116134827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)