CAT catalase [Homo sapiens (human)] - Gene

Summary

Go to the top of the page Help

Official Symbol: CATprovided by HGNC
Official Full Name: catalaseprovided by HGNC
Primary source: HGNC:1516
See related: Ensembl:ENSG00000121691; HPRD:00282; MIM:115500; Vega:OTTHUMG00000044353
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]

Genomic context

Go to the top of the page Help

Location :: 11p13

Sequence :: Chromosome: 11; NC_000011.9 (34460472..34493607)

See CAT in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study is the first to show that the polymorphism -21A>T CAT is associated with increased risk of cerebral stroke in hypertensive men, however, the relationship between the polymorphism and risk of cerebrovascular disease depends on whether the patients have environmental risk factors or not.
Title: [Catalase gene polymorphism is associated with increased risk of cerebral stroke in hypertensive patients].
Five SNPs from two genes (CAT (rs11032703, rs2300181, rs511895) and NQO1 (rs1800566, rs1437135)) were associated with asthma in an industrial rural area of Quebec.
Title: Association study of genes associated to asthma in a specific environment, in an asthma familial collection located in a rural area influenced by different industries.
Genetic polymorphisms of antioxidant enzymes in preterm infants.
Title: Genetic polymorphisms of antioxidant enzymes in preterm infants.
the study supports the notion of in vivo oxidative stress in systemic lupus erythematosus as indicated by the decrease in CAT activity; allelic variations in the CAT gene -262 are more likely to affect the expression or function of the enzyme
Title: Association of catalase gene polymorphisms with catalase activity and susceptibility to systemic lupus erythematosus in the Suez Canal area, Egypt.
Data show that T allele of catalase (CAT) and C allele of superoxide dismutase (SOD1) were significant risk factors for type 2 diabetes mellitus (T2DM).
Title: Association of polymorphic markers of the catalase and superoxide dismutase genes with type 2 diabetes mellitus.
The post-transcriptional control of gene expression via miRNA modulation regulates human catalase.
Title: MicroRNA-30b-mediated regulation of catalase expression in human ARPE-19 cells.
low CAT activity was associated with an increased risk of colorectal cancer(CRC); however, no evidence was found to support an association between CAT-21A > T polymorphism and CRC risk
Title: Association of catalase genotype with oxidative stress in the predication of colorectal cancer: modification by epidemiological factors.
coenzyme Q10, superoxide dismutase, and oxidative stress have roles in coronary artery disease, but the effect of malondialdehyde, catalase, and glutathione peroxidase is not significant
Title: The relationship between coenzyme Q10, oxidative stress, and antioxidant enzymes activities and coronary artery disease.
Results indicate that increased myeloperoxidase activity and decreased catalase activity is associated with increased oxidative stress, which may have a role in atherosclerotic processes in brucellosis patients.
Title: Serum myeloperoxidase activity and oxidative stress in patients with acute brucellosis.
analysis of polymorphisms of catalase exon 9: rs769217 in Hungarian microcytic anemia and beta-thalassemia patients
Title: A simple method for examination of polymorphisms of catalase exon 9: rs769217 in Hungarian microcytic anemia and beta-thalassemia patients.

Submit: New GeneRIF Correction See all (135)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

Go to the top of the page Help

Protein	Gene	Interaction	Pubs
Env, gp160, envelope glycoprotein	env	Free radical scavengers such as superoxide dismutase (SOD), dimethylthiourea (DMTU) and catalase attenuate morphine and gp160-induced human monocyte apoptosis	PubMed
Tat, p14	tat	HIV-1 Tat increases catalase and glutathione peroxidase 1 (GPX1) activities in human cardiac myocyte	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Source	Pubs	Description
NP_001743.1	NP_002825.3	PTPN11	BIND	PubMed	Cat interacts with Shp-2.
P04040	P42684	ABL2	HPRD	PubMed
P04040	P04040	CAT	HPRD	PubMed
P04040	Q06124	PTPN11	HPRD	PubMed
P04040	Q6EEV6	SUMO4	HPRD	PubMed
P04040	Q9BXR5	TLR10	HPRD	PubMed
BioGRID:107297	BioGRID:106543	ABL1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:107297	BioGRID:106545	ABL2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:107297	BioGRID:106848	APP	BioGRID	PubMed	Reconstituted Complex
BioGRID:107297	BioGRID:107297	CAT	BioGRID	PubMed	Co-crystal Structure; Two-hybrid
BioGRID:107297	BioGRID:108282	EHHADH	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:107297	BioGRID:109528	HSD17B4	BioGRID	PubMed	Co-fractionation
BioGRID:107297	BioGRID:115156	KEAP1	BioGRID	PubMed	Two-hybrid
BioGRID:107297	BioGRID:110368	MECP2	BioGRID	PubMed	Co-fractionation
BioGRID:107297	BioGRID:111788	PEX5	BioGRID	PubMed	Affinity Capture-MS; Protein-peptide; Two-hybrid
BioGRID:107297	BioGRID:112662	STIM1	BioGRID	PubMed	Co-fractionation
BioGRID:107297	BioGRID:132223	SUMO4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107297	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107297	BioGRID:120020	USP53	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

Go to the top of the page Help

Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
DNA damage response (only ATM dependent), organism-specific biosystem (from WikiPathways)
DNA damage response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
Folate Metabolism, organism-specific biosystem (from WikiPathways)
Folate Metabolism, organism-specific biosystem
Folate Metabolism
FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
FoxO family signaling, organism-specific biosystem
FoxO family signaling
Glyoxylate and dicarboxylate metabolism, organism-specific biosystem (from KEGG)
Glyoxylate and dicarboxylate metabolism, organism-specific biosystem
Glyoxylate and dicarboxylate metabolism
Glyoxylate and dicarboxylate metabolism, conserved biosystem (from KEGG)
Glyoxylate and dicarboxylate metabolism, conserved biosystem
Glyoxylate and dicarboxylate metabolism
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
Metabolism of nucleotides, organism-specific biosystem (from REACTOME)
Metabolism of nucleotides, organism-specific biosystemNucleotides and their derivatives are used for short-term energy storage (ATP, GTP), for intra- and extra-cellular signaling (cAMP; adenosine), as enzyme cofactors (NAD, FAD), and for the synthesis o...
Oxidative Stress, organism-specific biosystem (from WikiPathways)
Oxidative Stress, organism-specific biosystemOxidative stress represents an imbalance between the production and manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to rep...
Peroxisome, organism-specific biosystem (from KEGG)
Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
Peroxisome, conserved biosystem (from KEGG)
Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
Purine catabolism, organism-specific biosystem (from REACTOME)
Purine catabolism, organism-specific biosystemThe purine bases guanine and hypoxanthine (derived from adenine by events in the purine salvage pathways) are converted to xanthine and then to uric acid, which is excreted from the body (Watts 1974)...
Purine metabolism, organism-specific biosystem (from REACTOME)
Purine metabolism, organism-specific biosystemThe events of human purine metabolism are conveniently, if somewhat arbitrarily, grouped into four pathways: de novo synthesis of inosine 5'-monophosphate (IMP), the biosynthesis of other purine ribo...
Selenium Pathway, organism-specific biosystem (from WikiPathways)
Selenium Pathway, organism-specific biosystem
Selenium Pathway
Tryptophan metabolism, organism-specific biosystem (from KEGG)
Tryptophan metabolism, organism-specific biosystem
Tryptophan metabolism
Tryptophan metabolism, organism-specific biosystem (from WikiPathways)
Tryptophan metabolism, organism-specific biosystem
Tryptophan metabolism
Tryptophan metabolism, conserved biosystem (from KEGG)
Tryptophan metabolism, conserved biosystem
Tryptophan metabolism
ethanol degradation IV, organism-specific biosystem (from BIOCYC)
ethanol degradation IV, organism-specific biosystemThis ethanol degradation pathway begins with conversion of ethanol to acetaldehyde by peroxisomal catalase . The resulting acetaldehyde passes from the peroxisome to the cytoplasm and into the mitoch...
ethanol degradation IV, conserved biosystem (from BIOCYC)
ethanol degradation IV, conserved biosystemThis ethanol degradation pathway begins with conversion of ethanol to acetaldehyde by |FRAME: CPLX66-121 "peroxisomal catalase"| |CITS: [SALWAYJG2002]|. The resulting acetaldehyde passes from the per...
superoxide radicals degradation, organism-specific biosystem (from BIOCYC)
superoxide radicals degradation, organism-specific biosystem
superoxide radicals degradation

General gene information

Go to the top of the page Help

Markers

G66724 (e-PCR)
- UniSTS:166912

G66721 (e-PCR)
- UniSTS:166913

RH45987 (e-PCR)
- UniSTS:47879

STS-H15685 (e-PCR)
- UniSTS:44595

SHGC-132034 (e-PCR)
- UniSTS:173881

CAT_1268 (e-PCR)
- UniSTS:277054

RH27361 (e-PCR)
- UniSTS:83795

GDB:197896 (e-PCR)
- UniSTS:155991

RH78515 (e-PCR)
- UniSTS:42608

NoName (e-PCR)
- UniSTS:488057

WI-19159 (e-PCR)
- UniSTS:34683

GDB:181548 (e-PCR)
- UniSTS:155274

D11S4340 (e-PCR)
- UniSTS:76971

RH26629 (e-PCR)
- UniSTS:93107

RH122649 (e-PCR)
- UniSTS:135094

STS-X04076 (e-PCR)
- UniSTS:81147

G66723 (e-PCR)
- UniSTS:166909

G66722 (e-PCR)
- UniSTS:166910

G66725 (e-PCR)
- UniSTS:166911

Homology

Homologs of the CAT gene: The CAT gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, N.crassa, A.thaliana, and rice.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
NADP binding	IDA Inferred from Direct Assay more info	PubMed
aminoacylase activity	IEA Inferred from Electronic Annotation more info
antioxidant activity	IDA Inferred from Direct Assay more info	PubMed
catalase activity	IDA Inferred from Direct Assay more info	PubMed
catalase activity	TAS Traceable Author Statement more info
enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
heme binding	IDA Inferred from Direct Assay more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
oxidoreductase activity, acting on peroxide as acceptor	ISS Inferred from Sequence or Structural Similarity more info
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
receptor binding	IPI Inferred from Physical Interaction more info

Process	Evidence Code	Pubs
UV protection	IMP Inferred from Mutant Phenotype more info	PubMed
aerobic respiration	IEA Inferred from Electronic Annotation more info
cellular response to growth factor stimulus	IEA Inferred from Electronic Annotation more info
cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
hemoglobin metabolic process	IEA Inferred from Electronic Annotation more info
hydrogen peroxide catabolic process	IDA Inferred from Direct Assay more info	PubMed
menopause	IEA Inferred from Electronic Annotation more info
negative regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
nucleobase-containing small molecule metabolic process	TAS Traceable Author Statement more info
positive regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info
positive regulation of cell division	IEA Inferred from Electronic Annotation more info
positive regulation of phosphatidylinositol 3-kinase cascade	IEA Inferred from Electronic Annotation more info
protein homotetramerization	IDA Inferred from Direct Assay more info
protein tetramerization	IDA Inferred from Direct Assay more info	PubMed
purine nucleobase metabolic process	TAS Traceable Author Statement more info
purine nucleotide catabolic process	TAS Traceable Author Statement more info
response to hyperoxia	IEA Inferred from Electronic Annotation more info
response to hypoxia	IEA Inferred from Electronic Annotation more info
response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed
response to vitamin E	IEA Inferred from Electronic Annotation more info
small molecule metabolic process	TAS Traceable Author Statement more info
triglyceride metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
Golgi apparatus	IEA Inferred from Electronic Annotation more info
cytosol	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
lysosome	IEA Inferred from Electronic Annotation more info
mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
peroxisomal matrix	TAS Traceable Author Statement more info
peroxisomal membrane	ISS Inferred from Sequence or Structural Similarity more info
peroxisome	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: catalase

Names: catalase

NP_001743.1

EC 1.11.1.6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_013339.1 RefSeqGene

Range

5001..38136

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001752.3 → NP_001743.1 catalase

Status: REVIEWED

Source sequence(s)

AK291585, AL035079, AW023382

Consensus CDS

CCDS7891.1

UniProtKB/Swiss-Prot

P04040

Related

ENSP00000241052, OTTHUMP00000041455, ENST00000241052, OTTHUMT00000103197

Conserved Domains (2) summary

COG0753
Location:17 – 505
Blast Score: 1666

KatE; Catalase [Inorganic ion transport and metabolism]

cd08156
Location:68 – 497
Blast Score: 2281

catalase_clade_3; Clade 3 of the heme-binding enzyme catalase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p10 Primary Assembly

Range

34460472..34493607

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

34157829..34190968

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018922.1 Alternate CHM1_1.0

Range

34389135..34422268

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01060865.1 (60771..93910)	None
genomic	AL035079.14 (3399..36534)	None
genomic	AMYH01003488.1 (243586..276719)	None
genomic	AY545477.1	AAS37679.1
genomic	CH471064.2	EAW68170.1
		EAW68171.1
genomic	K02400.1	AAB59522.1
genomic	L13609.1	AAA16651.1
genomic	X04085.1	CAA27721.1
genomic	X04096.1	None
mRNA	AK291585.1	BAF84274.1
mRNA	AK301577.1	BAG63070.1
mRNA	AK310184.1	None
mRNA	AK315350.1	BAG37746.1
mRNA	AW023382.1	None
mRNA	AY028632.1	AAK29181.1
mRNA	BC027300.1	AAH27300.1
mRNA	BC110398.1	AAI10399.1
mRNA	BC112217.1	AAI12218.1
mRNA	BC112219.1	AAI12220.1
mRNA	BI551632.1	None
mRNA	CA748580.1	None
mRNA	X04076.1	CAA27717.1
other-genetic	HQ258304.1	ADR83058.1