U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Timm10b translocase of inner mitochondrial membrane 10B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84384, updated on 13-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Timm10bprovided by RGD
    Official Full Name
    translocase of inner mitochondrial membrane 10Bprovided by RGD
    Primary source
    RGD:71097
    See related
    Ensembl:ENSRNOG00000050846 AllianceGenome:RGD:71097
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fxc1; Tim9b; tim10b
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in protein transport. Predicted to be located in mitochondrial inner membrane. Predicted to be part of TIM22 mitochondrial import inner membrane insertion complex and mitochondrial intermembrane space protein transporter complex. Orthologous to human TIMM10B (translocase of inner mitochondrial membrane 10B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 130.9), Adrenal (RPKM 130.6) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Timm10b in Genome Data Viewer
    Location:
    1q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (169392355..169395201)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (159980525..159983371)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (170471265..170474111)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 3 Neighboring gene ADP-ribosylation factor interacting protein 2 Neighboring gene dynein heavy chain domain 1 Neighboring gene ribosomal RNA processing 8

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cloning of a novel cDNA expressed during the early stages of fracture healing. Hadjiargyrou M, et al. Biochem Biophys Res Commun, 1998 Aug 28. PMID 9731230
    2. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. Mühlenbein N, et al. J Biol Chem, 2004 Apr 2. PMID 14726512
    3. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. Bauer MF, et al. FEBS Lett, 1999 Dec 24. PMID 10611480
    4. Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria. Vukotic M, et al. Mol Cell, 2017 Aug 3. PMID 28712724
    5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM22 mitochondrial import inner membrane insertion complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of TIM22 mitochondrial import inner membrane insertion complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial intermembrane space protein transporter complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial intermembrane space protein transporter complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    mitochondrial import inner membrane translocase subunit Tim10 B
    Names
    fracture callus 1
    fracture callus protein 1
    fractured callus expressed transcript 1
    mitochondrial import inner membrane translocase subunit Tim9 B
    translocase of inner mitochondrial membrane 10 homolog B

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001389232.1 → NP_001376161.1  mitochondrial import inner membrane translocase subunit Tim10 B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O88471, Q9R1B1
      UniProtKB/TrEMBL
      A6I7L1, F1LTU8
      Related
      ENSRNOP00000068264.1, ENSRNOT00000076631.2
      Conserved Domains (1) summary
      pfam02953
      Location:3 → 64
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    2. NM_053371.3 → NP_445823.1  mitochondrial import inner membrane translocase subunit Tim10 B

      See identical proteins and their annotated locations for NP_445823.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O88471, Q9R1B1
      UniProtKB/TrEMBL
      A6I7L1, F1LTU8
      Conserved Domains (1) summary
      pfam02953
      Location:3 → 64
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      169392355..169395201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R1B1.1 GenPept UniProtKB/Swiss-Prot:Q9R1B1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous