CAK4 CDK-activating kinase 4 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Gene symbol: CAK4
Gene description: CDK-activating kinase 4
Primary source: Araport:AT1G66750
Locus tag: AT1G66750
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AT;CDKD;2; CAK4AT; CDK-activating kinase 4; CDK-ACTIVATING KINASE 4; CDKD1;2; CDKD;2; CYCLIN-DEPENDENT KINASE D1;2; F4N21.12; F4N21_12
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Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The phosphorylation of SPT5 by CDKD;2 enables it to recruit VIP5 to regulate chromatin and transcription in Arabidopsis.
Title: Phosphorylation of SPT5 by CDKD;2 Is Required for VIP5 Recruitment and Normal Flowering in Arabidopsis thaliana.
CDKD;2 plays a major role in cyclin-dependent kinase and carboxy-terminal domain phosphorylation.
Title: Diverse phosphoregulatory mechanisms controlling cyclin-dependent kinase-activating kinases in Arabidopsis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_105345.5

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activator activity	TAS Traceable Author Statement more info	PubMed
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of long-day photoperiodism, flowering	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
part_of transcription factor TFIIK complex	IEA Inferred from Electronic Annotation more info

NP_176847.1

CDK-activating kinase 4 (CAK4); FUNCTIONS IN: protein binding, protein serine/threonine kinase activity, kinase activity; INVOLVED IN: regulation of cyclin-dependent protein kinase activity; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: cyclin-dependent kinase D1;1 (TAIR:AT1G73690.1); Has 124001 Blast hits to 122583 proteins in 4490 species: Archae - 94; Bacteria - 13930; Metazoa - 46186; Fungi - 12564; Plants - 30685; Viruses - 410; Other Eukaryotes - 20132 (source: NCBI BLink).

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The following sections contain reference sequences that belong to a specific genome build. Explain