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    NCOA3 nuclear receptor coactivator 3 [ Homo sapiens (human) ]

    Gene ID: 8202, updated on 26-May-2016
    Official Symbol
    NCOA3provided by HGNC
    Official Full Name
    nuclear receptor coactivator 3provided by HGNC
    Primary source
    HGNC:HGNC:7670
    See related
    Ensembl:ENSG00000124151 HPRD:03570; MIM:601937; Vega:OTTHUMG00000033061
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42
    Summary
    The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]
    Orthologs
    Location:
    20q12
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 20 NC_000020.11 (47501857..47656877)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (46130601..46285621)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723442 Neighboring gene ribosomal protein L35a pseudogene Neighboring gene ribosomal protein S3A pseudogene Neighboring gene uncharacterized LOC105372635 Neighboring gene sulfatase 2 Neighboring gene uncharacterized LOC105376979

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
    NHGRI GWA Catalog
    Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of nuclear receptor coactivator 3 (NCOA3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat NCOA3 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
    tat p/CIP binds to HIV-1 Tat and enhances Tat-stimulated HIV-1 LTR promoter transactivation PubMed
    tat HIV-1 Tat may function as an adaptor molecule, efficiently stimulating the processes of transcription initiation and elongation through potentiation of the coupling of p160 co-activators and the P-TEFb complex PubMed
    nucleocapsid gag Nuclear receptor coactivator 3 (NCOA3) is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC141848

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    androgen receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ligand-dependent nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ligand-dependent nuclear receptor transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nuclear hormone receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    thyroid hormone receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    nuclear receptor coactivator 3
    Names
    CBP-interacting protein
    amplified in breast cancer 1 protein
    class E basic helix-loop-helix protein 42
    receptor-associated coactivator 3
    steroid receptor coactivator protein 3
    thyroid hormone receptor activator molecule 1
    NP_001167558.1
    NP_001167559.1
    NP_006525.2
    NP_858045.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016810.1 RefSeqGene

      Range
      5001..160021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001174087.1NP_001167558.1  nuclear receptor coactivator 3 isoform c

      See identical proteins and their annotated locations for NP_001167558.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (c) compared to isoform a.
      Source sequence(s)
      AB209863, AL034418, DB091786
      UniProtKB/TrEMBL
      Q59EE8
      Conserved Domains (6) summary
      pfam08815
      Location:10451092
      Nuc_rec_co-act; Nuclear receptor coactivator
      cd00083
      Location:3487
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:121186
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam07469
      Location:12901347
      DUF1518; Domain of unknown function (DUF1518)
      pfam08832
      Location:618704
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:264375
      PAS_11; PAS domain
    2. NM_001174088.1NP_001167559.1  nuclear receptor coactivator 3 isoform d

      See identical proteins and their annotated locations for NP_001167559.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses three alternate in-frame splice sites compared to variant 1, resulting in a shorter isoform (d) compared to isoform a.
      Source sequence(s)
      AF036892, AL034418, DB091786
      Consensus CDS
      CCDS54472.1
      UniProtKB/Swiss-Prot
      Q9Y6Q9
      Related
      ENSP00000361065, OTTHUMP00000031717, ENST00000371997, OTTHUMT00000080404
      Conserved Domains (6) summary
      pfam08815
      Location:10401087
      Nuc_rec_co-act; Nuclear receptor coactivator
      cd00083
      Location:3487
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:121186
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam07469
      Location:12821339
      DUF1518; Domain of unknown function (DUF1518)
      pfam08832
      Location:628714
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:264385
      PAS_11; PAS domain
    3. NM_006534.3NP_006525.2  nuclear receptor coactivator 3 isoform b

      See identical proteins and their annotated locations for NP_006525.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (b) compared to isoform a.
      Source sequence(s)
      AF012108, AL034418, DB091786
      Consensus CDS
      CCDS13406.1
      UniProtKB/Swiss-Prot
      Q9Y6Q9
      Related
      ENSP00000361073, OTTHUMP00000031716, ENST00000372004, OTTHUMT00000080403
      Conserved Domains (6) summary
      pfam08815
      Location:10451092
      Nuc_rec_co-act; Nuclear receptor coactivator
      cd00083
      Location:3487
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:121186
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam07469
      Location:12871344
      DUF1518; Domain of unknown function (DUF1518)
      pfam08832
      Location:618704
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:264375
      PAS_11; PAS domain
    4. NM_181659.2NP_858045.1  nuclear receptor coactivator 3 isoform a

      See identical proteins and their annotated locations for NP_858045.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AF016031, AL034418, DB091786
      Consensus CDS
      CCDS13407.1
      UniProtKB/Swiss-Prot
      Q9Y6Q9
      Related
      ENSP00000361066, OTTHUMP00000031718, ENST00000371998, OTTHUMT00000080405
      Conserved Domains (6) summary
      pfam08815
      Location:10451092
      Nuc_rec_co-act; Nuclear receptor coactivator
      cd00083
      Location:3487
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:121186
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam07469
      Location:12911348
      DUF1518; Domain of unknown function (DUF1518)
      pfam08832
      Location:618704
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:264375
      PAS_11; PAS domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p2 Primary Assembly

      Range
      47501857..47656877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018931.2 Alternate CHM1_1.1

      Range
      46033477..46188916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)