Rab13 RAB13, member RAS oncogene family [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rab13provided by RGD
Official Full Name: RAB13, member RAS oncogene familyprovided by RGD
Primary source: RGD:620880
See related: Ensembl:ENSRNOG00000016733 AllianceGenome:RGD:620880
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein kinase A catalytic subunit binding activity. Involved in several processes, including cellular response to insulin stimulus; establishment of Sertoli cell barrier; and protein kinase A signaling. Located in insulin-responsive compartment. Orthologous to human RAB13 (RAB13, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 89.6), Kidney (RPKM 72.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (177972535..177977679)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (175674894..175680043)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (189581209..189586358)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab13 and Desmosome Redistribution in Uterine Epithelial Cells During Early Pregnancy.
Title: Rab13 and Desmosome Redistribution in Uterine Epithelial Cells During Early Pregnancy.
In summary, ionomycin-promoted exocytosis of GLUT4 is partly reversed by siPKCtheta;, whereas ionomycin-inhibited endocytosis of GLUT4 requires both siPKCalpha and siPKCtheta;. PKCalpha and PKCtheta; contribute to ionomycin-induced phosphorylation of AS160 and TBC1D1. Rab13 is required for ionomycin-regulated GLUT4 exocytosis.
Title: PKC and Rab13 mediate Ca(2+) signal-regulated GLUT4 traffic.
Findings suggest that MICAL-L2 is an effector of insulin-activated Rab13, which links to GLUT4 through ACTN4, localizing GLUT4 vesicles at the muscle cell periphery to enable their fusion with the membrane.
Title: A complex of Rab13 with MICAL-L2 and α-actinin-4 is essential for insulin-dependent GLUT4 exocytosis.
RAB13 serves as a regulatory component in the assembly and restructuring of the TJ fibrils between adjacent Sertoli cells.
Title: RAB13 regulates Sertoli cell permeability barrier dynamics through protein kinase A.
Rab13 and Rab8A are Rab-GTPases activated by insulin and downstream of AS160 they regulate traffic of GLUT4 vesicles.
Title: Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells.
show that Rab13 regulates neurite outgrowth in the rat pheochromocytoma cell line PC12 through an interaction with JRAB/MICAL-L2.
Title: Rab13 regulates neurite outgrowth in PC12 cells through its effector protein, JRAB/MICAL-L2.
RAB13 functions in ectoplasmic specialization dynamics in the testis.
Title: RAB13 participates in ectoplasmic specialization dynamics in the rat testis.

Submit: New GeneRIF Correction

General gene information

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Markers

Rab13 (e-PCR), detects polymorphism
- UniSTS:281110

RH134804 (e-PCR)
- UniSTS:218082

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A catalytic subunit binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IEA Inferred from Electronic Annotation more info
involved_in Golgi to plasma membrane transport	ISO Inferred from Sequence Orthology more info
involved_in bicellular tight junction assembly	IEA Inferred from Electronic Annotation more info
involved_in bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in bicellular tight junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytic recycling	IEA Inferred from Electronic Annotation more info
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in endocytic recycling	ISS Inferred from Sequence or Structural Similarity more info
involved_in endosomal transport	ISO Inferred from Sequence Orthology more info
involved_in endosomal transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in endothelial cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of Sertoli cell barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose homeostasis	IC Inferred by Curator more info	PubMed
involved_in neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glucose import	IC Inferred by Curator more info	PubMed
involved_in protein kinase A signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein kinase A signaling	IEA Inferred from Electronic Annotation more info
involved_in protein kinase A signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell leading edge	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cell leading edge	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell leading edge	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in trans-Golgi network to recycling endosome transport	ISO Inferred from Sequence Orthology more info
involved_in trans-Golgi network to recycling endosome transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
NOT located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	TAS Traceable Author Statement more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	IEA Inferred from Electronic Annotation more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in insulin-responsive compartment	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info
is_active_in trans-Golgi network transport vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras-related protein Rab-13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031092.2 → NP_112354.1 ras-related protein Rab-13

See identical proteins and their annotated locations for NP_112354.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P35286, Q8K3X5

UniProtKB/TrEMBL

A0A0H2UHN5, A6J6K8

Related

ENSRNOP00000022626.3, ENSRNOT00000022627.5

Conserved Domains (1) summary

cd01867
Location:6 → 172

Rab8_Rab10_Rab13_like; Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

177972535..177977679

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103237.2 → XP_038959165.1 ras-related protein Rab-13 isoform X1

Conserved Domains (1) summary

cl38936
Location:1 → 91

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases