Display Settings:

Format

Send to:

Choose Destination
    • Showing Current items.

    ZNF222 zinc finger protein 222 [ Homo sapiens (human) ]

    Gene ID: 7673, updated on 25-Jul-2015
    Official Symbol
    ZNF222provided by HGNC
    Official Full Name
    zinc finger protein 222provided by HGNC
    Primary source
    HGNC:HGNC:13015
    See related
    Ensembl:ENSG00000159885; HPRD:15748; Vega:OTTHUMG00000182309
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Orthologs
    See ZNF222 in Epigenomics, MapViewer
    Location:
    19q13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (44025332..44033110)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44529494..44537263)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 230 Neighboring gene uncharacterized LOC105372414 Neighboring gene zinc finger protein 223 Neighboring gene zinc finger protein 284

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001129996.1NP_001123468.1  zinc finger protein 222 isoform 1

      See identical proteins and their annotated locations for NP_001123468.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      BC030261, DB185422
      Consensus CDS
      CCDS46098.1
      UniProtKB/Swiss-Prot
      Q9UK12
      Related
      ENSP00000375822, OTTHUMP00000268902, ENST00000391960, OTTHUMT00000460466
      Conserved Domains (6) summary
      cd07765
      Location:1755
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:1776
      KRAB; krueppel associated box
      COG5048
      Location:183315
      COG5048; FOG: Zn-finger [General function prediction only]
      pfam13465
      Location:284306
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:187207
      ZF_C2H2; Zn binding site [ion binding]
      sd00019
      Location:162179
      ZF_C2H2; Zn binding site [ion binding]
    2. NM_013360.2NP_037492.2  zinc finger protein 222 isoform 2

      See identical proteins and their annotated locations for NP_037492.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2 which is 40 aa shorter than isoform 1.
      Source sequence(s)
      AF187988, BC030261, DB185422
      Consensus CDS
      CCDS33045.1
      UniProtKB/Swiss-Prot
      Q9UK12
      Related
      ENSP00000187879, OTTHUMP00000268901, ENST00000187879, OTTHUMT00000460465
      Conserved Domains (5) summary
      cd07765
      Location:846
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:853
      KRAB; krueppel associated box
      pfam13465
      Location:244266
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:147167
      ZF_C2H2; Zn binding site [ion binding]
      sd00019
      Location:122139
      ZF_C2H2; Zn binding site [ion binding]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

      Range
      44025332..44033110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005259209.2XP_005259266.1  

      Conserved Domains (5) summary
      cd07765
      Location:1755
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:1762
      KRAB; krueppel associated box
      pfam13465
      Location:253275
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:156176
      ZF_C2H2; Zn binding site [ion binding]
      sd00019
      Location:131148
      ZF_C2H2; Zn binding site [ion binding]
    2. XM_005259208.2XP_005259265.1  

      Conserved Domains (5) summary
      cd07765
      Location:846
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:867
      KRAB; krueppel associated box
      pfam13465
      Location:275297
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:178198
      ZF_C2H2; Zn binding site [ion binding]
      sd00019
      Location:153170
      ZF_C2H2; Zn binding site [ion binding]

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      44531369..44539126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)