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    Ankrd42 ankyrin repeat domain 42 [ Mus musculus (house mouse) ]

    Gene ID: 73845, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ankrd42provided by MGI
    Official Full Name
    ankyrin repeat domain 42provided by MGI
    Primary source
    MGI:MGI:1921095
    See related
    Ensembl:ENSMUSG00000041343 AllianceGenome:MGI:1921095
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ikbn; 4931426M20; 4933417L02Rik
    Summary
    Enables NF-kappaB binding activity. Acts upstream of or within positive regulation of NF-kappaB transcription factor activity and positive regulation of cytokine production involved in inflammatory response. Located in nucleus. Orthologous to human ANKRD42 (ankyrin repeat domain 42). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 35.0), CNS E18 (RPKM 2.4) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 E1; 7 51.52 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (92230922..92286348, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (92584183..92637142, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene discs large MAGUK scaffold protein 2 Neighboring gene predicted gene, 53382 Neighboring gene STARR-seq mESC enhancer starr_19525 Neighboring gene predicted gene, 31491 Neighboring gene STARR-positive B cell enhancer ABC_E6571 Neighboring gene STARR-positive B cell enhancer ABC_E291 Neighboring gene STARR-seq mESC enhancer starr_19528 Neighboring gene coiled-coil domain containing 90B Neighboring gene predicted gene, 26944 Neighboring gene pantothenate kinase 1 pseudogene Neighboring gene PCF11 cleavage and polyadenylation factor subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IkappaBeta, a nuclear IkappaB protein, positively regulates the NF-kappaB-mediated expression of proinflammatory cytokines. Yamauchi S, et al. Proc Natl Acad Sci U S A, 2010 Jun 29. PMID 20547855, Free PMC Article
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IkappaBeta regulates the NF-kappaB-mediated transcription of a wide variety of proinflammatory genes, playing a crucial role in the regulation of innate immune responses.
      Title: IkappaBeta, a nuclear IkappaB protein, positively regulates the NF-kappaB-mediated expression of proinflammatory cytokines.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NF-kappaB binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NF-kappaB binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 42

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001407912.1 → NP_001394841.1  ankyrin repeat domain-containing protein 42 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC104921, AC158144
      UniProtKB/Swiss-Prot
      Q3V096, Q8BX55, Q8BZT3, Q8C0T6, Q8C0X5
      Related
      ENSMUSP00000061208.8, ENSMUST00000056106.14

    2. NM_001407913.1 → NP_001394842.1  ankyrin repeat domain-containing protein 42 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC104921, AC158144

    3. NM_001407914.1 → NP_001394843.1  ankyrin repeat domain-containing protein 42 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC104921, AC158144

    4. NM_028665.5 → NP_082941.2  ankyrin repeat domain-containing protein 42 isoform 1

      See identical proteins and their annotated locations for NP_082941.2

      Status: VALIDATED

      Source sequence(s)
      AC104921, AC158144
      Consensus CDS
      CCDS52310.1
      UniProtKB/TrEMBL
      A0A0R4J1P5
      Related
      ENSMUSP00000113767.2, ENSMUST00000118157.8
      Conserved Domains (4) summary
      cd00204
      Location:93 → 212
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:64 → 156
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:159 → 212
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:59 → 90
      ANK; ANK repeat [structural motif]

    RNA

    1. NR_176432.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104921, AC158144
      Related
      ENSMUST00000126305.8

    2. NR_176433.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104921, AC158144

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      92230922..92286348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508232.5 → XP_006508295.1  ankyrin repeat domain-containing protein 42 isoform X2

      Conserved Domains (4) summary
      PHA03095
      Location:17 → 288
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:59 → 90
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:64 → 156
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:269 → 318
      Ank_4; Ankyrin repeats (many copies)

    2. XM_036153478.1 → XP_036009371.1  ankyrin repeat domain-containing protein 42 isoform X3

      UniProtKB/TrEMBL
      B7ZNV8
      Related
      ENSMUSP00000147057.2, ENSMUST00000207131.2
      Conserved Domains (4) summary
      PHA03095
      Location:17 → 288
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:59 → 90
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:269 → 318
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:64 → 156
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_017312337.3 → XP_017167826.1  ankyrin repeat domain-containing protein 42 isoform X4

      Conserved Domains (4) summary
      PLN03192
      Location:133 → 193
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:59 → 90
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:64 → 156
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:28 → 80
      Ank_4; Ankyrin repeats (many copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V096.1 GenPept UniProtKB/Swiss-Prot:Q3V096

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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