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    Ppp1r16a protein phosphatase 1, regulatory subunit 16A [ Mus musculus (house mouse) ]

    Gene ID: 73062, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ppp1r16aprovided by MGI
    Official Full Name
    protein phosphatase 1, regulatory subunit 16Aprovided by MGI
    Primary source
    MGI:MGI:1920312
    See related
    Ensembl:ENSMUSG00000033819 AllianceGenome:MGI:1920312
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mypt3; 2900084E10Rik
    Summary
    Predicted to enable myosin phosphatase regulator activity and protein phosphatase 1 binding activity. Predicted to be involved in regulation of protein dephosphorylation. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Orthologous to human PPP1R16A (protein phosphatase 1 regulatory subunit 16A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 50.6), small intestine adult (RPKM 34.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 D3; 15 36.25 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76555843..76579119)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76671643..76694919)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57852 Neighboring gene STARR-positive B cell enhancer ABC_E9419 Neighboring gene STARR-positive B cell enhancer ABC_E3145 Neighboring gene transmembrane protein 276 Neighboring gene kinesin family member C2 Neighboring gene STARR-positive B cell enhancer ABC_E5491 Neighboring gene forkhead box H1 Neighboring gene STARR-seq mESC enhancer starr_39060 Neighboring gene glutamic pyruvic transaminase, soluble Neighboring gene major facilitator superfamily domain containing 3 Neighboring gene RecQ protein-like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PPP1R16A, the membrane subunit of protein phosphatase 1beta, signals nuclear translocation of the nuclear receptor constitutive active/androstane receptor. Sueyoshi T, et al. Mol Pharmacol, 2008 Apr. PMID 18202305
    2. Cloning and identification of MYPT3: a prenylatable myosin targetting subunit of protein phosphatase 1. Skinner JA, et al. Biochem J, 2001 May 15. PMID 11336659, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. R16A at the membrane may mediate the PB signal to initiate CAR nuclear translocation, through a mechanism including its dimerization and inhibition of PP1beta activity.
      Title: PPP1R16A, the membrane subunit of protein phosphatase 1beta, signals nuclear translocation of the nuclear receptor constitutive active/androstane receptor.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 16A
    Names
    mFLJ00392 protein
    myosin phosphatase targeting subunit 3
    myosin phosphatase, target subunit 3
    protein phosphatase 1, regulatory (inhibitor) subunit 16A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358933.1 → NP_001345862.1  protein phosphatase 1 regulatory subunit 16A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC156550
      Consensus CDS
      CCDS27585.1
      UniProtKB/Swiss-Prot
      Q4V9Z1, Q923M0
      UniProtKB/TrEMBL
      Q3TB53
      Related
      ENSMUSP00000155515.2, ENSMUST00000135388.3
      Conserved Domains (3) summary
      COG0666
      Location:138 → 328
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:98 → 285
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:74 → 101
      ANK; ANK repeat [structural motif]

    2. NM_033371.3 → NP_203535.1  protein phosphatase 1 regulatory subunit 16A

      See identical proteins and their annotated locations for NP_203535.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC156550
      Consensus CDS
      CCDS27585.1
      UniProtKB/Swiss-Prot
      Q4V9Z1, Q923M0
      UniProtKB/TrEMBL
      Q3TB53
      Related
      ENSMUSP00000037356.9, ENSMUST00000037551.15
      Conserved Domains (3) summary
      COG0666
      Location:138 → 328
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:98 → 285
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:74 → 101
      ANK; ANK repeat [structural motif]

    RNA

    1. NR_152559.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most zexpected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC156550
      Related
      ENSMUST00000150399.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76555843..76579119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q923M0.1 GenPept UniProtKB/Swiss-Prot:Q923M0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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