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    Cnih3 cornichon family AMPA receptor auxiliary protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690252, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Cnih3provided by RGD
    Official Full Name
    cornichon family AMPA receptor auxiliary protein 3provided by RGD
    Primary source
    RGD:1582859
    See related
    Ensembl:ENSRNOG00000022724 AllianceGenome:RGD:1582859
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CNIH-3
    Summary
    Enables channel regulator activity. Involved in regulation of AMPA receptor activity. Acts upstream of or within glutamatergic synaptic transmission and regulation of membrane potential. Located in dendritic shaft and postsynaptic membrane. Part of AMPA glutamate receptor complex. Orthologous to human CNIH3 (cornichon family AMPA receptor auxiliary protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 56.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    13q26
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (95548440..95739500)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (93016707..93208168)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (99663150..99770625)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene cornichon family member 4 Neighboring gene WD repeat domain 26 Neighboring gene glutamic acid-rich protein-like Neighboring gene coiled-coil domain containing 121, retrogene 1 Neighboring gene dynein axonemal heavy chain 14 Neighboring gene mitochondrial ribosomal protein S11, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structures of the AMPA receptor in complex with its auxiliary subunit cornichon. Nakagawa T. Science, 2019 Dec 6. PMID 31806817
    2. Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3. Shanks NF, et al. J Neurosci, 2014 Sep 3. PMID 25186755, Free PMC Article
    3. Cornichon proteins determine the subunit composition of synaptic AMPA receptors. Herring BE, et al. Neuron, 2013 Mar 20. PMID 23522044, Free PMC Article
    4. Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors. Schwenk J, et al. Science, 2009 Mar 6. PMID 19265014
    5. Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. Shi Y, et al. Proc Natl Acad Sci U S A, 2010 Sep 14. PMID 20805473, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. reports high-resolution cryo-electron microscopy structures of AMPAR in complex with CNIH3. Contrary to its predicted membrane topology, CNIH3 lacks an extracellular domain and instead contains four membrane-spanning helices
      Title: Structures of the AMPA receptor in complex with its auxiliary subunit cornichon.
    2. Residues in the membrane-proximal region of CNIHs that contribute to AMPAR binding and a segment in the CNIH-2/3 extracellular loop required for both physical interaction and gating modulation of the AMPAR, are identified.
      Title: Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3.
    3. findings show that the majority of AMPARs in the brain are coassembled with CNIH-2 & CNIH-3; cornichons increase surface expression of AMPARs, & alter channel gating by markedly slowing deactivation & desensitization kinetics
      Title: Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of AMPA receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within synaptic transmission, glutamatergic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendritic shaft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein cornichon homolog 3
    Names
    cornichon 3
    cornichon homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166578.2 → NP_001160050.1  protein cornichon homolog 3

      See identical proteins and their annotated locations for NP_001160050.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      D0Q0Y7
      UniProtKB/TrEMBL
      A6JGJ9
      Related
      ENSRNOP00000079333.1, ENSRNOT00000094141.1
      Conserved Domains (1) summary
      pfam03311
      Location:7 → 151
      Cornichon; Cornichon protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      95548440..95739500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272628.1 → XP_063128698.1  protein cornichon homolog 3 isoform X4

    2. XM_039091108.2 → XP_038947036.1  protein cornichon homolog 3 isoform X3

      Conserved Domains (1) summary
      pfam03311
      Location:11 → 134
      Cornichon; Cornichon protein

    3. XM_039091107.2 → XP_038947035.1  protein cornichon homolog 3 isoform X3

      Conserved Domains (1) summary
      pfam03311
      Location:11 → 134
      Cornichon; Cornichon protein

    4. XM_063272624.1 → XP_063128694.1  protein cornichon homolog 3 isoform X1

    5. XM_063272626.1 → XP_063128696.1  protein cornichon homolog 3 isoform X1

    6. XM_063272627.1 → XP_063128697.1  protein cornichon homolog 3 isoform X1

    7. XM_063272625.1 → XP_063128695.1  protein cornichon homolog 3 isoform X1

    8. XM_039091106.2 → XP_038947034.1  protein cornichon homolog 3 isoform X2

      UniProtKB/TrEMBL
      A6JGJ9
      Conserved Domains (1) summary
      pfam03311
      Location:7 → 135
      Cornichon; Cornichon protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D0Q0Y7.1 GenPept UniProtKB/Swiss-Prot:D0Q0Y7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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