Dnd1 DND microRNA-mediated repression inhibitor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnd1provided by RGD
Official Full Name: DND microRNA-mediated repression inhibitor 1provided by RGD
Primary source: RGD:1583648
See related: Ensembl:ENSRNOG00000016894 AllianceGenome:RGD:1583648
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable mRNA 3'-UTR binding activity. Involved in germ cell development and spermatogenesis. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Used to study teratocarcinoma. Orthologous to human DND1 (DND microRNA-mediated repression inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 33.5), Spleen (RPKM 25.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (28652712..28655336, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (28378692..28381316, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (29608588..29611212, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dnd1 ter mutation causes germ cell loss, infertility and initiates gonadal teratomas.
Title: The ter mutation in the rat Dnd1 gene initiates gonadal teratomas and infertility in both genders.
The inactivation of the putative tumor suppressor gene Dnd1 facilitates the immortalization of late EGCs in vitro.
Title: Loss of Dnd1 facilitates the cultivation of genital ridge-derived rat embryonic germ cells.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:471090 (e-PCR)
- UniSTS:471090

Dnd1 (e-PCR), detects polymorphism
- UniSTS:471090

RH130568 (e-PCR)
- UniSTS:213852

Hars (e-PCR), detects polymorphism
- UniSTS:143316

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
NOT enables miRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within germ cell development	ISO Inferred from Sequence Orthology more info
involved_in mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of miRNA-mediated gene silencing	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of miRNA-mediated gene silencing	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dead end protein homolog 1

Names: dead end homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109379.1 → NP_001102849.1 dead end protein homolog 1

See identical proteins and their annotated locations for NP_001102849.1

Status: PROVISIONAL

Source sequence(s)

CH473974

UniProtKB/TrEMBL

A6J335, A6J336, D3ZQ06

Related

ENSRNOP00000022685.4, ENSRNOT00000022685.5

Conserved Domains (2) summary

TIGR01648
Location:18 → 219

hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

cd20313
Location:254 → 333

DSRM_DND1; double-stranded RNA binding motif of dead end protein homolog 1 (DND1) and similar proteins