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    BRCA1 breast cancer 1, early onset [ Homo sapiens (human) ]

    Gene ID: 672, updated on 22-May-2013
    Official Symbol
    BRCA1provided by HGNC
    Official Full Name
    breast cancer 1, early onsetprovided by HGNC
    Primary source
    HGNC:1100
    See related
    Ensembl:ENSG00000012048; HPRD:00218; MIM:113705; Vega:OTTHUMG00000157426
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IRIS; PSCP; BRCAI; BRCC1; PNCA4; RNF53; BROVCA1; PPP1R53
    Summary
    This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]
    Location :
    17q21
    Sequence :
    Chromosome: 17; NC_000017.10 (41196312..41277500, complement)
    See BRCA1 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene vesicle amine transport protein 1 homolog (T. californica) Neighboring gene Rho family GTPase 2 Neighboring gene ribosomal protein L21 pseudogene 4 Neighboring gene putative protein FAM215A-like Neighboring gene neighbor of BRCA1 gene 2 (non-protein coding) Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 29

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. BRCA1 protein expression and its correlation with ER/PR status in sporadic and familial breast cancer in Eastern Indian patients--a hospital based study. Ashraf M, et al. J Indian Med Assoc, 2011 Dec. PMID 23469566.
    2. Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination. Tang J, et al. Nat Struct Mol Biol, 2013 Mar. PMID 23377543.
    3. [Loss of heterozygosity (LOH) at BRCA1 loci in primary breast cancers]. Miyoshi Y. Nihon Rinsho, 2012 Sep. PMID 23350388.
    4. BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer cells. Grotsky DA, et al. J Cell Biol, 2013 Jan 21. PMID 23337117.
    5. Methylation of breast cancer susceptibility gene 1 (BRCA1) predicts recurrence in patients with curatively resected stage I non-small cell lung cancer. Harada H, et al. Cancer, 2013 Feb 15. PMID 23335114.

    See all (1852) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Loss of BRCA1 function leads to hydrogen peroxide generation in both epithelial breast cancer cells and neighboring stromal fibroblasts, and promotes the onset of a reactive glycolytic stroma, with increased MCT4 and decreased Cav-1 expression.
      Title: BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: implications for breast cancer prevention with antioxidant therapies.
    2. REVIEW: includes how ER alpha could influence BRCA1-defective tumor progression, phenotype of BRCA1-defective cancers, and role of BRCA1 in other cancers
      Title: Insights into the targeted elimination of BRCA1-defective cancer stem cells.
    3. Data suggest that the BRCA1-associated IRIF core corresponds to chromatin regions associated with repair by homologous recombination, and the enrichment of BRCA1 in IRIF represents a temporal switch in the DNA repair program.
      Title: BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair.
    4. Evidence based on spontaneous chromosome abnormalities and epidemiologic data indicates strong effects from exogenous mutagens and does not support the inevitability of cancer in all BRCA1/2 mutation carriers.
      Title: Evidence that BRCA1- or BRCA2-associated cancers are not inevitable.
    5. results suggest that polymorphic BRCA1, particularly T43893C polymorphism, may protect against salivary gland carcinoma
      Title: Functional single-nucleotide polymorphisms in the BRCA1 gene and risk of salivary gland carcinoma.
    6. The ectopic expression of BRCA1 is associated with the genesis, progression, and prognosis of young breast cancer patients.
      Title: The ectopic expression of BRCA1 is associated with genesis, progression, and prognosis of breast cancer in young patients.
    7. for women with invasive ovarian cancer, the short-term survival advantage of carrying a BRCA1 or BRCA2 mutation does not lead to a long-term survival benefit
      Title: Long-term ovarian cancer survival associated with mutation in BRCA1 or BRCA2.
    8. review of progress in understanding of BRCA1 and BRCA2 mutations in ovarian cancers and how these findings affect therapeutics; differing prognostic effects of BRCA2 and BRCA1 mutations is likely due to differing roles of BRCA1 and BRCA2 in homologous recombination repair and stronger association between the BRCA2 mutation and hypermutator phenotype
      Title: Differing clinical impact of BRCA1 and BRCA2 mutations in serous ovarian cancer.
    9. BRCA mutations account for a substantial proportion of hereditary breast/ovarian cancer in Southern Chinese population.
      Title: Identification of BRCA1/2 founder mutations in Southern Chinese breast cancer patients using gene sequencing and high resolution DNA melting analysis.
    10. RIF1 accumulation at DSB sites is strongly antagonized by BRCA1 and its interacting partner CtIP
      Title: A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice.
    Submit: New GeneRIF Correction See all (1175)

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    BRCA1 and BRCA2 Hereditary Breast and Ovarian Cancer

    Summary from GeneReviews: BRCA1 and BRCA2 Hereditary Breast/Ovarian Cancer Go to GeneReviews

    Disease Characteristics
    A germline mutation in BRCA1 or BRCA2 predisposes to breast and ovarian cancer as well as other cancers. The risk of developing cancer that is associated with a germline BRCA1 or BRCA2 mutation, which has been derived from families with multiple affected individuals, families with few affected individuals, and from population-based studies, appears to be variable within families. Prognosis for breast and ovarian cancer depends on the stage at which the cancer is diagnosed; however, studies on survival have revealed conflicting results for individuals with germline BRCA1 or BRCA2 mutations when compared to controls.
    Diagnosis Testing
    Molecular genetic testing for germline BRCA1 and BRCA2 mutations is available on a clinical basis for individuals who are identified to be at high risk based on their personal and/or family history and for at-risk relatives of an individual with an identified germline BRCA1 or BRCA2 mutation. No currently available technique can guarantee the identification of all cancer-predisposing mutations in BRCA1 or BRCA2. Furthermore, mutations of uncertain clinical significance may be identified.
    Genetic Counseling
    Germline mutations in BRCA1 and BRCA2 are inherited in an autosomal dominant manner. Each offspring of an individual with a BRCA1 or BRCA2 germline mutation has a 50% chance of inheriting the mutation. Molecular genetic testing of asymptomatic family members at risk of inheriting either a BRCA1 or BRCA2 germline mutation is feasible once the family-specific mutation has been identified. Prenatal testing is possible for pregnancies at increased risk if the cancer-predisposing mutation in the family is known; however, requests for prenatal diagnosis of adult-onset diseases are uncommon and require careful genetic counseling.
    References

    Breast-ovarian cancer, familial 1

    Summary from GeneReviews: BRCA1 and BRCA2 Hereditary Breast/Ovarian Cancer Go to GeneReviews

    Disease Characteristics
    A germline mutation in BRCA1 or BRCA2 predisposes to breast and ovarian cancer as well as other cancers. The risk of developing cancer that is associated with a germline BRCA1 or BRCA2 mutation, which has been derived from families with multiple affected individuals, families with few affected individuals, and from population-based studies, appears to be variable within families. Prognosis for breast and ovarian cancer depends on the stage at which the cancer is diagnosed; however, studies on survival have revealed conflicting results for individuals with germline BRCA1 or BRCA2 mutations when compared to controls.
    Diagnosis Testing
    Molecular genetic testing for germline BRCA1 and BRCA2 mutations is available on a clinical basis for individuals who are identified to be at high risk based on their personal and/or family history and for at-risk relatives of an individual with an identified germline BRCA1 or BRCA2 mutation. No currently available technique can guarantee the identification of all cancer-predisposing mutations in BRCA1 or BRCA2. Furthermore, mutations of uncertain clinical significance may be identified.
    Genetic Counseling
    Germline mutations in BRCA1 and BRCA2 are inherited in an autosomal dominant manner. Each offspring of an individual with a BRCA1 or BRCA2 germline mutation has a 50% chance of inheriting the mutation. Molecular genetic testing of asymptomatic family members at risk of inheriting either a BRCA1 or BRCA2 germline mutation is feasible once the family-specific mutation has been identified. Prenatal testing is possible for pregnancies at increased risk if the cancer-predisposing mutation in the family is known; however, requests for prenatal diagnosis of adult-onset diseases are uncommon and require careful genetic counseling.
    References
    Protein Gene Interaction Pubs
    Vpr, p15 vpr HIV-1 Vpr stimulates the focus formation of Rad51 and BRCA1, which are involved in repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) PubMed
    vpr HIV-1 Vpr induces phosphorylation of BRCA1 at serine 1423 in an ATR-dependent manner PubMed
    vpr HIV-1 Vpr expression in HeLa cells induces formation of nuclear foci containing H2AFX and BRCA1 PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NC_000017.9 NP_005230.1 ETS2    BIND  PubMed ETS2 (Ets-2) interacts with BRCA1 promoter. This interaction was modeled on a demonstrated interaction between ETS2 from an unspecified species and BRCA1 promoter from an unspecified species. 
    NP_009225.1 NP_004371.1 CREBBP    BIND  PubMed CBP interacts with BRCA1. This interaction was modelled on a demonstrated interaction between human BRCA1 and mouse CBP. 
    NP_009225.1 NP_001420.1 EP300    BIND  PubMed p300 interacts with BRCA1. 
    NP_009225.1 NP_002392.2 MAP3K3    BIND  PubMed BRCA1 interacts with MEKK3. 
    NP_009225.1 NP_004765.2 MED1    BIND  PubMed BRCA1 interacts with TRAP220. 
    NP_009226.1 NP_009226.1 BRCA1    BIND  PubMed BRCA1 possesses E3 ubiquitin ligase activity and auto-ubiquitinates 
    NP_009226.1 NP_005892.1 SMAD2    BIND  PubMed BRCA1 interacts with Smad2. This interaction was modeled on a demonstrated interaction between BRCA1 from human and Smad2 from an unspecified species. 
    NP_009226.1 NP_005893.1 SMAD3    BIND  PubMed BRCA1 interacts with Smad3. 
    NP_009226.1 NP_005350.1 SMAD4    BIND  PubMed BRCA1 interacts with Smad4. This interaction was modeled on a demonstrated interaction between BRCA1 from human and Smad4 from an unspecified species. 
    NP_009226.1 NP_061828.1 UBB    BIND  PubMed BRCA1 interacts with Ub. This interaction was modelled on a demonstrated interaction between human BRCA1 and Ub from an unspecified source. 
    NP_009227.1 NP_000655.1 ACACA    BIND  PubMed BRCA1 interacts with acetyl-CoA carboxylase. 
    NP_009227.1 NP_001175.1 ATR    BIND  PubMed BRCA1 physically and functionally interacts with ATR during genotoxic stress 
    NP_009227.1 NP_000050.1 BRCA2    BIND  PubMed BRCA1 interacts with BRCA2. 
    NP_009227.1 NP_003905.1 CCNA1    BIND  PubMed BRCA1 associates with Cyclin A 
    NP_009227.1 NP_114172.1 CCNB1    BIND  PubMed BRCA1 is a tyrosine phosphoprotein that associates with Cyclin B1 
    NP_009227.1 NP_444284.1 CCND1    BIND  PubMed BRCA1 associates with Cyclin D1 
    NP_009227.1 NP_001789.2 CDK2    BIND  PubMed BRCA1 associates with CDK2 
    NP_009227.1 NP_000066.1 CDK4    BIND  PubMed BRCA1 associates with CDK4 
    NP_009227.1 NP_001311.3 CSNK2B    BIND  PubMed BRCA1 is phosphorylated by Casein kinase 2 through a physical interaction with CSNK2B 
    NP_009227.1 NP_005216.1 E2F1    BIND  PubMed BRCA1 associates with E2F-1 
    NP_009227.1 NP_001941.2 E2F4    BIND  PubMed BRCA1 associates with E2F-4 
    NP_009227.1 NP_000126.1 FANCA    BIND  PubMed BRCA1 interacts with FANCA. 
    NP_009227.1 NP_004955.2 HDAC1    BIND  PubMed BRCA1 interacts with HDAC1 
    NP_009227.1 NP_001518.1 HDAC2    BIND  PubMed BRCA1 interacts with HDAC2 
    NP_009227.1 NP_002219.1 JUN    BIND  PubMed BRCA1 interacts with c-Jun. 
    NP_009227.1 NP_002220.1 JUNB    BIND  PubMed BRCA1 interacts with JunB. 
    NP_009227.1 NP_005345.2 JUND    BIND  PubMed BRCA1 interacts with JunD. 
    NP_009227.1 NP_006760.1 LMO4    BIND  PubMed The LIM domain protein LMO4 interacts with BRCA1 
    NP_009227.1 NP_000242.1 MSH2    BIND  PubMed BRCA1 interacts with MSH2 in the absence of ADP-MSH2 interaction. 
    NP_009227.1 NP_000170.1 MSH6    BIND  PubMed BRCA1 associates with MSH6. 
    NP_009227.1 NP_002458.1 MYC    BIND  PubMed BRCA1 association with c-Myc, a proto-oncogene that is implicated in tumorigenesis, embryonic development and apoptosis, inhibits its transcriptional and transforming activity in cells. 
    NP_009227.1 NP_002496.1 NFYA    BIND  PubMed BRCA1 interacts with NF-YA 
    NP_009227.1 NP_004679.1 NMI    BIND  PubMed BRCA1 interacts with Nmi. 
    NP_009227.1 NP_036477.1 NUFIP1    BIND  PubMed BRCA1 interacts with NUFIP. 
    NP_009227.1 NP_002688.2 POU2F1    BIND  PubMed BRCA1 interacts with Oct-1. 
    NP_009227.1 NP_002866.2 RAD51    BIND  PubMed BRCA1 and Rad51 associate in mitotic and meiotic cells 
    NP_009227.1 NP_597994.1 RAD51    BIND  PubMed BRCA1 and Rad51 associate in mitotic and meiotic cells 
    NP_009227.1 NP_000312.1 RB1    BIND  PubMed BRCA1 interacts with Rb. 
    NP_009227.1 NP_005601.1 RBBP4    BIND  PubMed BRCA1 interacts with RbAp48. 
    NP_009227.1 NP_002884.1 RBBP7    BIND  PubMed BRCA1 interacts with RbAp46. 
    NP_009227.1 NP_002885.1 RBBP8    BIND  PubMed BRCA1 interacts with CtIP. 
    NP_009227.1 AAF67726.1 SP1    BIND  PubMed BRCA1 interacts with Sp1. 
    NP_009227.1 NP_000537.2 TP53    BIND  PubMed BRCA1 physically associates with p53 and stimulates its transcriptional activity 
    NP_009227.1     BIND  PubMed BRCA1 interacts with Nmi homodimer 
    NP_009235.1 NP_000537.2 TP53    BIND  PubMed BRCA1a interacts with p53. 
    P38398 P00519 ABL1    HPRD  PubMed  
    P38398 Q13085 ACACA    HPRD  PubMed  
    P38398 P31749 AKT1    HPRD  PubMed  
    P38398 P10275 AR    HPRD  PubMed  
    P38398 P18846 ATF1    HPRD  PubMed  
    P38398 Q13535 ATR    HPRD  PubMed  
    P38398 O14965 AURKA    HPRD  PubMed  
    P38398 Q92560 BAP1    HPRD  PubMed  
    P38398 Q99728 BARD1    HPRD  PubMed  
    P38398 BRAP2 BRAP    HPRD  PubMed  
    P38398 P38398 BRCA1    HPRD  PubMed  
    P38398 P51587 BRCA2    HPRD  PubMed  
    P38398 P46736 BRCC3    HPRD  PubMed  
    P38398 Q9BX63 BRIP1    HPRD  PubMed  
    P38398 P42574 CASP3    HPRD  PubMed  
    P38398 P78396 CCNA1    HPRD  PubMed  
    P38398 P20248 CCNA2    HPRD  PubMed  
    P38398 P14635 CCNB1    HPRD  PubMed  
    P38398 P24385 CCND1    HPRD  PubMed  
    P38398 P06493 CDK1    HPRD  PubMed  
    P38398 P24941 CDK2    HPRD  PubMed  
    P38398 P11802 CDK4    HPRD  PubMed  
    P38398 P50613 CDK7    HPRD  PubMed  
    P38398 O96017 CHEK2    HPRD  PubMed  
    P38398 Q9HAW4 CLSPN    HPRD  PubMed  
    P38398 Q92793 CREBBP    HPRD  PubMed  
    P38398 P68400 CSNK2A1    HPRD  PubMed  
    P38398 P67870 CSNK2B    HPRD  PubMed  
    P38398 Q05048 CSTF1    HPRD  PubMed  
    P38398 Q13363 CTBP1    HPRD  PubMed  
    P38398 Q96SD1 DCLRE1C    HPRD  PubMed  
    P38398 Q08211 DHX9    HPRD  PubMed  
    P38398 Q01094 E2F1    HPRD  PubMed  
    P38398 Q16254 E2F4    HPRD  PubMed  
    P38398 P19419 ELK1    HPRD  PubMed  
    P38398 Q09472 EP300    HPRD  PubMed  
    P38398 P03372 ESR1    HPRD  PubMed  
    P38398 Q6UWZ7 FAM175A    HPRD  PubMed  
    P38398 O15360 FANCA    HPRD  PubMed  
    P38398 Q9BXW9 FANCD2    HPRD  PubMed  
    P38398 Q14192 FHL2    HPRD  PubMed  
    P38398 Growth factor independent 1B GFI1B    HPRD  PubMed  
    P38398 P16104 H2AFX    HPRD  PubMed  
    P38398 Q13547 HDAC1    HPRD  PubMed  
    P38398 Q92769 HDAC2    HPRD  PubMed  
    P38398 Q16666 IFI16    HPRD  PubMed  
    P38398 P23458 JAK1    HPRD  PubMed  
    P38398 O60674 JAK2    HPRD  PubMed  
    P38398 P05412 JUN    HPRD  PubMed  
    P38398 P17275 JUNB    HPRD  PubMed  
    P38398 P17535 JUND    HPRD  PubMed  
    P38398 P52292 KPNA2    HPRD  PubMed  
    P38398 O60684 KPNA6    HPRD  PubMed  
    P38398 P61968 LMO4    HPRD  PubMed  
    P38398 Q99759 MAP3K3    HPRD  PubMed  
    P38398 Q14676 MDC1    HPRD  PubMed  
    P38398 Q15648 MED1    HPRD  PubMed  
    P38398 Q13503 MED21    HPRD  PubMed  
    P38398 P40692 MLH1    HPRD  PubMed  
    P38398 P51948 MNAT1    HPRD  PubMed  
    P38398 P01106 MYC    HPRD  PubMed  
    P38398 O60934 NBN    HPRD  PubMed  
    P38398 Q8WX92 NELFB    HPRD  PubMed  
    P38398 P19838 NFKB1    HPRD  PubMed  
    P38398 P23511 NFYA    HPRD  PubMed  
    P38398 Q13287 NMI    HPRD  PubMed  
    P38398 Q9UHK0 NUFIP1    HPRD  PubMed  
    P38398 P24928 POLR2A    HPRD  PubMed  
    P38398 P53803 POLR2K    HPRD  PubMed  
    P38398 P14859 POU2F1    HPRD  PubMed  
    P38398 P62136 PPP1CA    HPRD  PubMed  
    P38398 P07602 PSAP    HPRD  PubMed  
    P38398 Q06609 RAD51    HPRD  PubMed  
    P38398 P06400 RB1    HPRD  PubMed  
    P38398 Q09028 RBBP4    HPRD  PubMed  
    P38398 Q16576 RBBP7    HPRD  PubMed  
    P38398 Q99708 RBBP8    HPRD  PubMed  
    P38398 Q04206 RELA    HPRD  PubMed  
    P38398 P35251 RFC1    HPRD  PubMed  
    P38398 Q15796 SMAD2    HPRD  PubMed  
    P38398 P84022 SMAD3    HPRD  PubMed  
    P38398 Q13485 SMAD4    HPRD  PubMed  
    P38398 P51531 SMARCA2    HPRD  PubMed  
    P38398 P51532 SMARCA4    HPRD  PubMed  
    P38398 Q14683 SMC1A    HPRD  PubMed  
    P38398 P08047 SP1    HPRD  PubMed  
    P38398 P42224 STAT1    HPRD  PubMed  
    P38398 P40763 STAT3    HPRD  PubMed  
    P38398 P42229 STAT5A    HPRD  PubMed  
    P38398 P11388 TOP2A    HPRD  PubMed  
    P38398 P04637 TP53    HPRD  PubMed  
    P38398 Q12888 TP53BP1    HPRD  PubMed  
    P38398 Q9Y4A5 TRRAP    HPRD  PubMed  
    P38398 P68366 TUBA4A    HPRD  PubMed  
    P38398 P07437 TUBB    HPRD  PubMed  
    P38398 P23258 TUBG1    HPRD  PubMed  
    P38398 Ubiquitin B UBB    HPRD  PubMed  
    P38398 P61077 UBE2D3    HPRD  PubMed  
    P38398 P68036 UBE2L3    HPRD  PubMed  
    P38398 Q15853 USF2    HPRD  PubMed  
    P38398 P55072 VCP    HPRD  PubMed  
    P38398 P18887 XRCC1    HPRD  PubMed  
    P38398 P25490 YY1    HPRD  PubMed  
    P38398 Q9GZX5 ZNF350    HPRD  PubMed  
    BioGRID:107140 BioGRID:106543 ABL1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; FRET; Reconstituted Complex 
    BioGRID:107140 BioGRID:106549 ACACA    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Protein-peptide; Reconstituted Complex 
    BioGRID:107140 BioGRID:106586 ACTG1    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:106699 AHR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:106710 AKT1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107140 BioGRID:106725 ALDH9A1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107140 BioGRID:116523 ANKRD26    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:116847 ANKRD28    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:124841 ANKRD44    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:106669 AP2A1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:106831 APLP2    BioGRID  PubMed Far Western 
    BioGRID:107140 BioGRID:106862 AR    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:106898 ARNT    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:114528 ASH2L    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:31972 ASM4    BioGRID  PubMed Synthetic Rescue 
    BioGRID:107140 BioGRID:106956 ATF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:106962 ATM    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-purification; Protein-peptide; Reconstituted Complex 
    BioGRID:107140 BioGRID:106971 ATP1B1    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:106973 ATP1B3    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:107027 ATR    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Protein-peptide; Reconstituted Complex 
    BioGRID:107140 BioGRID:313463 ATRIP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:112666 AURKA    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107140 BioGRID:112671 AURKC    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:118855 BABAM1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:107047 BACH1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Protein-peptide; Reconstituted Complex 
    BioGRID:107140 BioGRID:113911 BAP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:107056 BARD1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Co-localization; Co-purification; FRET; PCA; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:107068 BCL2    BioGRID  PubMed Affinity Capture-Western; FRET 
    BioGRID:107140 BioGRID:107110 BLM    BioGRID  PubMed Co-purification 
    BioGRID:107140 BioGRID:122954 BORA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:113912 BRAP    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:128767 BRAT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Protein-peptide; Reconstituted Complex 
    BioGRID:107140 BioGRID:107142 BRCA2    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:122599 BRCC3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:107140 BioGRID:118883 BRD7    BioGRID  PubMed Affinity Capture-Western; Co-localization; Two-hybrid 
    BioGRID:107140 BioGRID:114946 BRE    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:107140 BioGRID:123841 BRIP1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-localization; Protein-peptide; Reconstituted Complex 
    BioGRID:107140 BioGRID:222625 Bap1    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:198301 Bard1    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:117642 CABYR    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:107282 CAPZB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:114417 CCNA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107140 BioGRID:107331 CCNA2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:107332 CCNB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107140 BioGRID:107067 CCND1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107140 BioGRID:107338 CCNE1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:107342 CCNH    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:31745 CCR4    BioGRID  PubMed Synthetic Rescue 
    BioGRID:107140 BioGRID:107420 CDK1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107140 BioGRID:111154 CDK16    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:107140 BioGRID:107452 CDK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107140 BioGRID:107454 CDK4    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107140 BioGRID:107455 CDK5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107140 BioGRID:107457 CDK7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:107458 CDK8    BioGRID  PubMed Co-purification 
    BioGRID:107140 BioGRID:107459 CDK9    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:107463 CDKN2A    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:107140 BioGRID:120743 CDKN2AIP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:107466 CDKN2D    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107140 BioGRID:115191 CEP350    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107140 BioGRID:107495 CETN1    BioGRID  PubMed Co-localization 
    BioGRID:107140 BioGRID:107536 CHEK1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107140 BioGRID:116369 CHEK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107140 BioGRID:122015 CLSPN    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107140 BioGRID:117427 CNRIP1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107140 BioGRID:120223 CNTLN    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:127444 CNTN4    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:107674 COL1A1    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:127317 COMMD1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107140 BioGRID:116447 COPE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:107775 CREB1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:107140 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex 
    BioGRID:107140 BioGRID:130121 CRIPAK    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:115271 CRYZL1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107140 BioGRID:107841 CSNK2A1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107140 BioGRID:107843 CSNK2B    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:107859 CSTF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107140 BioGRID:107860 CSTF2    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:107140 BioGRID:107869 CTBP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:126653 CTCFL    BioGRID  PubMed Protein-peptide 
    BioGRID:107140 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:113724 CUBN    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:120455 DALRD3    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:117730 DAZAP1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:107140 BioGRID:116129 DBF4    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:122170 DCLRE1C    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:108002 DCN    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:121353 DDX24    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:34079 DEF1    BioGRID  PubMed Synthetic Rescue 
    BioGRID:107140 BioGRID:31903 DHH1    BioGRID  PubMed Synthetic Rescue 
    BioGRID:107140 BioGRID:108025 DHX9    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:109534 DNAJA1    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:114547 DNAJA3    BioGRID  PubMed Protein-peptide 
    BioGRID:107140 BioGRID:109569 DNAJB1    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:126834 DNHD1    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:110810 DRG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:108117 DYNC1H1    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:108201 E2F1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:108206 E2F4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107140 BioGRID:114211 EIF3B    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:108290 EIF4A2    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:115024 EIF5B    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:108320 ELK4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:108338 ENO1    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex 
    BioGRID:107140 BioGRID:108386 ERCC6    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107140 BioGRID:121155 ERO1LB    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:107140 BioGRID:108414 ETS1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107140 BioGRID:108420 ETV5    BioGRID  PubMed FRET 
    BioGRID:107140 BioGRID:113271 EZR    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107140 BioGRID:123911 FAM175A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:107140 BioGRID:108472 FANCA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:108474 FANCD2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Two-hybrid 
    BioGRID:107140 BioGRID:125038 FBXO44    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:117655 FBXO5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:116291 FGFR1OP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:108565 FHL2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:108602 FLI1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107140 BioGRID:108603 FLII    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:108605 FLNA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:108598 FOXO3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:118996 FTSJ2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:108895 GATA3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:113924 GFI1B    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:128266 GGN    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:115671 GNB2L1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:116452 GPN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:119359 GPN3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:109215 GTF2E1    BioGRID  PubMed Co-purification 
    BioGRID:107140 BioGRID:109217 GTF2F1    BioGRID  PubMed Co-purification 
    BioGRID:107140 BioGRID:109223 GTF2H4    BioGRID  PubMed Co-purification 
    BioGRID:107140 BioGRID:109224 GTF2I    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:107140 BioGRID:114738 GTF3C4    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:608838 GUSBP1    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:107140 BioGRID:114927 H2AFY    BioGRID  PubMed Co-localization 
    BioGRID:107140 BioGRID:109315 HDAC1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107140 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western; Negative Genetic; Reconstituted Complex 
    BioGRID:107140 BioGRID:122781 HECTD3    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:114438 HERC2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107140 BioGRID:116289 HIBADH    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107140 BioGRID:109338 HIF1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:163543 HIST1H2AC    BioGRID  PubMed Biochemical Activity 
    BioGRID:107140 BioGRID:113934 HIST2H2AC    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107140 BioGRID:126025 HIST2H3C    BioGRID  PubMed Co-localization 
    BioGRID:107140 BioGRID:109343 HIVEP1    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:109404 HMMR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:109420 HNRNPA1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:107140 BioGRID:109422 HNRNPA2B1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:107140 BioGRID:109425 HNRNPD    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:107140 BioGRID:119358 HSPA14    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:109544 HSPA8    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:109561 HSPD1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107140 BioGRID:109654 IFI16    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:109840 INPP1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107140 BioGRID:123294 ITIH5    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:200523 Ifi204    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:107140 BioGRID:109919 JAK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:109920 JAK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:109928 JUN    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:109929 JUNB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:109930 JUND    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:109931 JUP    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:108918 KAT2A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:116667 KDM1A    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107140 BioGRID:115114 KIAA0101    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:121775 KIAA1967    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:116723 KIF1B    BioGRID  PubMed Protein-peptide 
    BioGRID:107140 BioGRID:110036 KPNA2    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:119549 LCMT1    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:110140 LDHC    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:114113 LMO4    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:110296 MAN2C1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107140 BioGRID:110378 MAP3K1    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:110379 MAP3K3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107140 BioGRID:114838 MAP4K4    BioGRID  PubMed Protein-peptide 
    BioGRID:107140 BioGRID:111580 MAPK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:111581 MAPK3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:122551 MAPKAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:115014 MDC1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:107140 BioGRID:111465 MED1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:115294 MED13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:114830 MED17    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107140 BioGRID:114807 MED21    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:107140 BioGRID:114829 MED23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:115196 MED24    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107140 BioGRID:110438 MLH1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:107140 BioGRID:34843 MLP2    BioGRID  PubMed Synthetic Rescue 
    BioGRID:107140 BioGRID:110474 MNAT1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107140 BioGRID:116134 MORF4L1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:110501 MRE11A    BioGRID  PubMed Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex 
    BioGRID:107140 BioGRID:122366 MRPL36    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:35160 MRPL39    BioGRID  PubMed Synthetic Rescue 
    BioGRID:107140 BioGRID:110573 MSH2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:110574 MSH3    BioGRID  PubMed Protein-peptide; Reconstituted Complex 
    BioGRID:107140 BioGRID:109211 MSH6    BioGRID  PubMed Affinity Capture-MS; Co-purification; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:110584 MSN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:114652 MTA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:108757 MTOR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:115871 MYL12A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:110763 NBN    BioGRID  PubMed Affinity Capture-Western; Co-localization; Co-purification 
    BioGRID:107140 BioGRID:115761 NCOA2    BioGRID  PubMed Protein-peptide; Reconstituted Complex 
    BioGRID:107140 BioGRID:113841 NCOA3    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Reconstituted Complex 
    BioGRID:107140 BioGRID:110631 ND1    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:117421 NELFB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:110866 NFYA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:116630 NINL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:128814 NKAPL    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:114561 NMI    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:115828 NPC2    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:110929 NPM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:117807 NUFIP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:34076 NUP120    BioGRID  PubMed Synthetic Rescue 
    BioGRID:107140 BioGRID:34213 NUP133    BioGRID  PubMed Synthetic Rescue 
    BioGRID:107140 BioGRID:115297 NUP153    BioGRID  PubMed Protein-peptide 
    BioGRID:107140 BioGRID:32624 NUP170    BioGRID  PubMed Synthetic Rescue 
    BioGRID:107140 BioGRID:35040 NUP188    BioGRID  PubMed Synthetic Rescue 
    BioGRID:107140 BioGRID:31599 NUP2    BioGRID  PubMed Synthetic Rescue 
    BioGRID:107140 BioGRID:111010 ODF2    BioGRID  PubMed Co-localization 
    BioGRID:107140 BioGRID:111041 ORC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:117130 ORC3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:117939 PABPC1    BioGRID  PubMed Affinity Capture-Western; Far Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:122843 PALB2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:111110 PAX2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:111127 PCBP2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:107140 BioGRID:111204 PEG3    BioGRID  PubMed Far Western 
    BioGRID:107140 BioGRID:111788 PEX5    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:111260 PGR    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107140 BioGRID:116459 PHB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:121686 PHF12    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:114124 PIAS1    BioGRID  PubMed Biochemical Activity; Co-localization 
    BioGRID:107140 BioGRID:119624 PIAS4    BioGRID  PubMed Biochemical Activity; Co-localization 
    BioGRID:107140 BioGRID:111313 PIK3R1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107140 BioGRID:119015 PILRB    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:117262 PISD    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:111426 POLR2A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-purification 
    BioGRID:107140 BioGRID:159574 POLR2A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:111428 POLR2C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:111429 POLR2D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:111430 POLR2E    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:111432 POLR2G    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:111433 POLR2H    BioGRID  PubMed Biochemical Activity 
    BioGRID:107140 BioGRID:111434 POLR2I    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:111435 POLR2J    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:123498 POLR2M    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:31292 POM34    BioGRID  PubMed Synthetic Rescue 
    BioGRID:107140 BioGRID:120763 POMGNT1    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:111447 POU2F1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:119596 PPHLN1    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:111493 PPP1CA    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107140 BioGRID:111494 PPP1CB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:128092 PPP1R18    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:111499 PPP1R3A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:124202 PPP1R9B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:111507 PPP2CA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:111519 PPP2R5C    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107140 BioGRID:111529 PPP6C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:116537 PPP6R1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:120579 PPP6R3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:111541 PREP    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:111577 PRKDC    BioGRID  PubMed Protein-peptide 
    BioGRID:107140 BioGRID:109512 PRMT1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107140 BioGRID:120755 PRR5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:111639 PSAP    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:111660 PSMA6    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:114179 PSMG1    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:111824 RAD23B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:115417 RAD50    BioGRID  PubMed Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:111825 RAD51    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex 
    BioGRID:107140 BioGRID:115359 RANBP9    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:111860 RB1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:107140 BioGRID:111863 RBBP4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:111866 RBBP7    BioGRID  PubMed Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:111867 RBBP8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-localization; Protein-peptide; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:111868 RBL1    BioGRID  PubMed Co-localization; Reconstituted Complex 
    BioGRID:107140 BioGRID:111869 RBL2    BioGRID  PubMed Co-localization; Reconstituted Complex 
    BioGRID:107140 BioGRID:115301 RBX1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107140 BioGRID:111894 RDX    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:114797 RECQL5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:111902 RELA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:111913 RFC1    BioGRID  PubMed Co-purification 
    BioGRID:107140 BioGRID:111914 RFC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:128962 RICTOR    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107140 BioGRID:119981 RNF216    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:114270 RNGTT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:112037 RPA1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:107140 BioGRID:122959 RPAP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:122783 RPAP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:121364 RPGRIP1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107140 BioGRID:112079 RPL31    BioGRID  PubMed Far Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:120494 RPRD1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:121820 RPRD1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:110115 RPSA    BioGRID  PubMed Co-localization 
    BioGRID:107140 BioGRID:128576 RTKN2    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:128409 RWDD4    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:120034 SDK2    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:117455 SH2B1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:113692 SHFM1    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:116983 SIRT1    BioGRID  PubMed Negative Genetic 
    BioGRID:107140 BioGRID:116593 SIRT2    BioGRID  PubMed Negative Genetic 
    BioGRID:107140 BioGRID:112391 SKP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:112393 SKP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:112479 SMARCA2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:112481 SMARCA4    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:107140 BioGRID:112482 SMARCB1    BioGRID  PubMed Co-purification 
    BioGRID:107140 BioGRID:112483 SMARCC1    BioGRID  PubMed Co-purification 
    BioGRID:107140 BioGRID:112485 SMARCC2    BioGRID  PubMed Co-purification 
    BioGRID:107140 BioGRID:112487 SMARCD2    BioGRID  PubMed Co-purification 
    BioGRID:107140 BioGRID:113871 SMC1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:116661 SNRNP200    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107140 BioGRID:114263 SNX3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107140 BioGRID:121852 SNX6    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:116247 SOX30    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:126337 SPATA4    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:33308 SPT4    BioGRID  PubMed Synthetic Rescue 
    BioGRID:107140 BioGRID:35159 SPT5    BioGRID  PubMed Synthetic Rescue 
    BioGRID:107140 BioGRID:112592 SRC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:112324 SRSF1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-RNA 
    BioGRID:107140 BioGRID:112622 SSFA2    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:112649 STAT1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:112653 STAT5A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:112674 STRN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:35211 SUB1    BioGRID  PubMed Synthetic Rescue 
    BioGRID:107140 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-Western; FRET; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107140 BioGRID:112496 SUMO3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:112698 SUPT6H    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:117003 TARDBP    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:107140 BioGRID:112760 TARS    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:115140 TATDN2    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:129118 TCTEX1D2    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:112872 TERF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:112873 TERF2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:123703 TEX101    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:112878 TFAP2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:112880 TFAP2C    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:112881 TFAP4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:124047 THOC3    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:112946 TLE4    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    NP_001058.2 TOP2A    BIND  PubMed TOP2A (Topo II) interacts with BRCA1 
    BioGRID:107140 BioGRID:113006 TOP2A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:116256 TOPBP1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:107140 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:107140 BioGRID:113011 TP53BP1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:107140 BioGRID:114181 TP63    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:113014 TP73    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:113021 TPM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:113023 TPM3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:125031 TPTE2    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:116624 TPX2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:114333 TRIM24    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:132031 TRIM74    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:113900 TRRAP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Far Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:129721 TSEN54    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:128444 TUBB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:113134 TUBG1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization; Co-purification; Reconstituted Complex 
    BioGRID:107140 BioGRID:113139 TULP2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107140 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:107140 BioGRID:113169 UBE2D1    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:113170 UBE2D2    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:113171 UBE2D3    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:113172 UBE2E1    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:113173 UBE2E2    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:115740 UBE2E3    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:113177 UBE2I    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; FRET 
    BioGRID:107140 BioGRID:119555 UBE2J1    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:109340 UBE2K    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:113180 UBE2L3    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:113182 UBE2N    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:118858 UBE2T    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107140 BioGRID:120572 UBE2W    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:113185 UBE3A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107140 BioGRID:119239 UBXN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:119697 UIMC1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization 
    BioGRID:107140 BioGRID:113238 USF2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:113242 USH2A    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:114553 USP2    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:113258 VCP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:113264 VDR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:133813 VSIG8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:123518 WBSCR16    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107140 BioGRID:121649 WDR48    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:116350 WDR6    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:113319 WNT2B    BioGRID  PubMed Far Western 
    BioGRID:107140 BioGRID:113340 XIST    BioGRID  PubMed Co-localization 
    BioGRID:107140 BioGRID:113353 XRCC5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107140 BioGRID:108822 XRCC6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:110959 YBX1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:113373 ZBTB14    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:120739 ZCCHC8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107140 BioGRID:117422 ZDHHC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107140 BioGRID:120173 ZNF280D    BioGRID  PubMed Two-hybrid 
    BioGRID:107140 BioGRID:121889 ZNF350    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107140 BioGRID:113416 ZSCAN21    BioGRID  PubMed Two-hybrid 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    androgen receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    		  
    tubulin binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator TAS
    Traceable Author Statement
    more info
    		 PubMed 
    DNA repair TAS
    Traceable Author Statement
    more info
    		  
    G2 DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    androgen receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to indole-3-methanol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    double-strand break repair TAS
    Traceable Author Statement
    more info
    		  
    double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    double-strand break repair via homologous recombination TAS
    Traceable Author Statement
    more info
    		  
    fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    intrinsic apoptotic signaling pathway in response to DNA damage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of centriole replication NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    negative regulation of fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of histone H3-K9 methylation IDA
    Inferred from Direct Assay
    more info
    		  
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of histone H3-K4 methylation IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of histone H3-K9 acetylation IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of histone H4-K16 acetylation IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of histone H4-K20 methylation IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of histone acetylation IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent TAS
    Traceable Author Statement
    more info
    		 PubMed 
    postreplication repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein K6-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of cell motility IDA
    Inferred from Direct Assay
    more info
    		  
    regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of transcription from RNA polymerase III promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    response to DNA damage stimulus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    response to estrogen stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    substrate adhesion-dependent cell spreading IDA
    Inferred from Direct Assay
    more info
    		  
    Component Evidence Code Pubs
    BRCA1-A complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    BRCA1-BARD1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    colocalizes_with filamentous actin IDA
    Inferred from Direct Assay
    more info
    		  
    colocalizes_with focal adhesion IDA
    Inferred from Direct Assay
    more info
    		  
    gamma-tubulin ring complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ruffle IDA
    Inferred from Direct Assay
    more info
    		  
    ubiquitin ligase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Preferred Names
    breast cancer type 1 susceptibility protein
    Names
    breast cancer type 1 susceptibility protein
    RING finger protein 53
    BRCA1/BRCA2-containing complex, subunit 1
    protein phosphatase 1, regulatory subunit 53
    breast and ovarian cancer susceptibility protein 1
    breast and ovarian cancer sususceptibility protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_005905.2 RefSeqGene

      Range
      92501..173689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_292

    mRNA and Protein(s)

    1. NM_007294.3 → NP_009225.1  breast cancer type 1 susceptibility protein isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as BRCA1a) represents the more frequently occurring transcript. It encodes the full-length BRCA1 protein (isoform 1), which is also known as p220.
      Source sequence(s)
      AL701927, BC072418, BU617173, BU679389, U14680
      Consensus CDS
      CCDS11453.1
      UniProtKB/Swiss-Prot
      P38398
      Related
      ENSP00000350283, OTTHUMP00000212143, ENST00000357654, OTTHUMT00000348798
      Conserved Domains (5) summary
      cd00027
      Location:1763 – 1842
      Blast Score: 107
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd00162
      Location:23 – 68
      Blast Score: 134
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam04873
      Location:655 – 978
      Blast Score: 1301
      EIN3; Ethylene insensitive 3
      pfam12820
      Location:344 – 507
      Blast Score: 809
      BRCT_assoc; Serine-rich domain associated with BRCT
      pfam13923
      Location:20 – 65
      Blast Score: 135
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    2. NM_007297.3 → NP_009228.2  breast cancer type 1 susceptibility protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream translational start codon, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      BC072418, BU617173, BU679389, U14680
      Consensus CDS
      CCDS11459.2
      UniProtKB/TrEMBL
      E9PFZ0
      UniProtKB/Swiss-Prot
      P38398
      Related
      ENSP00000418775, OTTHUMP00000212148, ENST00000493795, OTTHUMT00000348803
      Conserved Domains (3) summary
      cd00027
      Location:1716 – 1795
      Blast Score: 108
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      pfam04873
      Location:608 – 931
      Blast Score: 1299
      EIN3; Ethylene insensitive 3
      pfam12820
      Location:297 – 460
      Blast Score: 807
      BRCT_assoc; Serine-rich domain associated with BRCT

    3. NM_007298.3 → NP_009229.2  breast cancer type 1 susceptibility protein isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as BRCA1-delta11b) differs in the 5' UTR and uses two alternate in-frame splice sites in the central coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AL701927, BC072418, BU617173, BU679389, U64805
      Consensus CDS
      CCDS11454.2
      UniProtKB/TrEMBL
      E7ETR2
      UniProtKB/Swiss-Prot
      P38398
      Related
      ENSP00000312236, ENST00000352993
      Conserved Domains (3) summary
      cd00027
      Location:659 – 738
      Blast Score: 108
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd00162
      Location:23 – 68
      Blast Score: 131
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam13923
      Location:20 – 65
      Blast Score: 132
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    4. NM_007299.3 → NP_009230.2  breast cancer type 1 susceptibility protein isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, uses two alternate in-frame splice sites in the central coding region, and lacks an alternate exon in the 3' coding region that results in a frameshift, compared to variant 1. The encoded isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC072418, BU617173, BU679389
      Consensus CDS
      CCDS11455.2
      UniProtKB/Swiss-Prot
      P38398
      Related
      ENSP00000417148, OTTHUMP00000212149, ENST00000468300, OTTHUMT00000348804
      Conserved Domains (2) summary
      cd00162
      Location:23 – 68
      Blast Score: 126
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam13923
      Location:20 – 65
      Blast Score: 127
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    5. NM_007300.3 → NP_009231.2  breast cancer type 1 susceptibility protein isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate in-frame exon and an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
      Source sequence(s)
      AC135721, AL701927, BC072418, BC115037, BU617173, BU679389, U14680
      Consensus CDS
      CCDS11456.2
      UniProtKB/TrEMBL
      E9PFC7
      UniProtKB/Swiss-Prot
      P38398
      UniProtKB/TrEMBL
      Q1RMC1
      Related
      ENSP00000418960, OTTHUMP00000212147, ENST00000471181, OTTHUMT00000348802
      Conserved Domains (5) summary
      cd00027
      Location:1784 – 1863
      Blast Score: 107
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd00162
      Location:23 – 68
      Blast Score: 134
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam04873
      Location:655 – 978
      Blast Score: 1300
      EIN3; Ethylene insensitive 3
      pfam12820
      Location:344 – 507
      Blast Score: 808
      BRCT_assoc; Serine-rich domain associated with BRCT
      pfam13923
      Location:20 – 65
      Blast Score: 135
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    RNA

    1. NR_027676.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) includes an alternate 5' exon and alternate splice sites in two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF005068, AK308084, BC072418, BU617173, BU679389, U14680

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p10 Primary Assembly

      Range
      41196312..41277500, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      36962663..37043809, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018928.1 Alternate CHM1_1.0

      Range
      41986424..42067607, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_007295.2: Suppressed sequence

      Description
      NM_007295.2: This RefSeq was permanently suppressed because only partial transcript evidence exists for this transcript variant, and its full-length exon combination is unclear.

    2. NM_007296.2: Suppressed sequence

      Description
      NM_007296.2: This RefSeq was permanently suppressed because there is no full-length transcript support for the exon combination of this variant.

    3. NM_007301.2: Suppressed sequence

      Description
      NM_007301.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    4. NM_007302.2: Suppressed sequence

      Description
      NM_007302.2: This RefSeq was permanently suppressed because only partial transcript evidence exists for this transcript variant, and its full-length exon combination is unclear.

    5. NM_007303.2: Suppressed sequence

      Description
      NM_007303.2: This RefSeq was permanently suppressed because the full-length sequence of this transcript variant is unavailable, and its full-length exon combination is unclear.

    6. NM_007305.2: Suppressed sequence

      Description
      NM_007305.2: This RefSeq was permanently suppressed because the full-length sequence of this transcript variant is unavailable, and its full-length exon combination is unclear.

    7. NM_007306.2: Suppressed sequence

      Description
      NM_007306.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01006390.1 (48539..93505) None
    genomic ABBA01006391.1 None
    genomic ABBA01006392.1 None
    genomic ABBA01006393.1 None
    genomic AC135721.4 (33970..115124) None
    genomic AF284812.1 AAF97939.1
    genomic AF507076.1 AAN61423.1
    genomic AF507078.1 AAN61425.1
    genomic AMYH01008402.1 (18492..99675) None
    genomic AY093484.1 AAM18218.1
    genomic AY093485.1 AAM18219.1
    genomic AY093486.1 AAM18220.1
    genomic AY093487.1 AAM18221.1
    genomic AY093489.1 AAM18222.1
    genomic AY093490.1 AAM18223.1
    genomic AY093492.1 AAM18225.1
    genomic AY093493.1 AAM18226.1
    genomic AY144588.1 AAN10167.1
    genomic AY273801.1 AAP12647.1
    genomic AY304547.1 AAP70031.1
    genomic AY706911.1 AAU21563.1
    genomic AY706912.1 AAU21564.1
    genomic CH471152.1 EAW60922.1
      EAW60923.1
      EAW60924.1
      EAW60925.1
      EAW60926.1
      EAW60927.1
      EAW60928.1
      EAW60929.1
      EAW60930.1
      EAW60931.1
      EAW60932.1
      EAW60933.1
      EAW60934.1
      EAW60935.1
      EAW60936.1
      EAW60937.1
      EAW60938.1
      EAW60939.1
      EAW60940.1
      EAW60941.1
      EAW60942.1
    genomic DQ116737.1 AAZ16492.1
    genomic DQ145822.1 AAZ79406.1
    genomic DQ145823.1 AAZ79407.1
    genomic DQ145825.1 AAZ79409.1
    genomic DQ145826.1 AAZ79410.1
    genomic DQ190450.1 ABA29208.1
    genomic DQ190451.1 ABA29211.1
    genomic DQ190452.1 ABA29214.1
    genomic DQ190453.1 ABA29217.1
    genomic DQ190454.1 ABA29220.1
    genomic DQ190455.1 ABA29223.1
    genomic DQ190456.1 ABA29226.1
    genomic DQ190457.1 ABA29229.1
    genomic DQ299305.1 ABB87053.1
    genomic DQ299306.1 ABB87054.1
    genomic DQ299307.1 ABB87055.1
    genomic DQ299308.1 ABB87056.1
    genomic DQ299309.1 ABB87057.1
    genomic DQ299310.1 ABB87058.1
    genomic DQ299311.1 ABB87059.1
    genomic DQ299312.1 ABB87060.1
    genomic DQ299313.1 ABB87061.1
    genomic DQ299314.1 ABB87062.1
    genomic DQ299315.1 ABB87063.1
    genomic DQ299316.1 ABB87064.1
    genomic DQ299317.1 ABB87065.1
    genomic DQ299318.1 ABB87066.1
    genomic DQ299319.1 ABB87067.1
    genomic DQ299321.1 ABB87069.1
    genomic DQ299322.1 ABB87070.1
    genomic DQ299323.1 ABB87071.1
    genomic DQ299324.1 ABB87072.1
    genomic DQ299325.1 ABB87073.1
    genomic DQ299326.1 ABB87074.1
    genomic DQ299327.1 ABB87075.1
    genomic DQ299328.1 ABB87076.1
    genomic DQ299329.1 ABB87077.1
    genomic DQ299330.1 ABB87078.1
    genomic DQ299331.1 ABB87079.1
    genomic DQ478408.1 ABF14462.1
    genomic L78833.1 AAC37594.1
    genomic U15595.1 None
    genomic U37574.1 AAC50330.1
    genomic U61268.1 AAB40910.1
    genomic Y08757.1 CAA70003.1
    mRNA AF005068.1 AAB61673.1
    mRNA AF274503.1 None
    mRNA AK293762.1 BAG57181.1
    mRNA AK307553.1 None
    mRNA AK308084.1 None
    mRNA AK316200.1 BAH14571.1
    mRNA AL701927.1 None
    mRNA AY354539.2 AAQ92977.1
    mRNA AY751490.1 AAU93634.1
    mRNA BC012577.1 None
    mRNA BC030969.1 AAH30969.1
    mRNA BC038947.1 None
    mRNA BC046142.1 None
    mRNA BC062429.1 AAH62429.1
    mRNA BC072418.1 AAH72418.1
    mRNA BC085615.1 AAH85615.1
    mRNA BC106745.1 AAI06746.1
    mRNA BC106746.1 AAI06747.1
    mRNA BC114511.1 None
    mRNA BC114562.1 None
    mRNA BC115037.1 AAI15038.1
    mRNA BU617173.1 None
    mRNA BU679389.1 None
    mRNA DQ333386.1 ABC59810.1
    mRNA DQ333387.1 ABC59811.1
    mRNA DQ363751.1 ABC88652.1
    mRNA JN686490.1 AEQ98814.1
    mRNA U14680.1 AAA73985.1
    mRNA U64805.1 AAC00049.1
    mRNA U68041.1 AAB08105.1
    mRNA Y08864.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38398.2 GenPept UniProtKB/Swiss-Prot:P38398

    Additional Links

    Gene LinkOut

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