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    Mrps18b mitochondrial ribosomal protein S18B [ Mus musculus (house mouse) ]

    Gene ID: 66973, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mrps18bprovided by MGI
    Official Full Name
    mitochondrial ribosomal protein S18Bprovided by MGI
    Primary source
    MGI:MGI:1914223
    See related
    Ensembl:ENSMUSG00000024436 AllianceGenome:MGI:1914223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S18mt-b; MRP-S18-2; 2400002C15Rik
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including brain; early conceptus; genitourinary system; heart; and liver. Orthologous to human MRPS18B (mitochondrial ribosomal protein S18B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 47.5), large intestine adult (RPKM 47.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 B1; 17 18.76 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36221272..36227332, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35910380..35916440, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310061I04 gene Neighboring gene alpha tubulin acetyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E10949 Neighboring gene predicted gene 16279 Neighboring gene STARR-seq mESC enhancer starr_42481 Neighboring gene protein phosphatase 1, regulatory subunit 10 Neighboring gene microRNA 1894 Neighboring gene STARR-seq mESC enhancer starr_42482 Neighboring gene ring-box 1, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cell stemness is maintained upon concurrent expression of RB and the mitochondrial ribosomal protein S18-2. Mushtaq M, et al. Proc Natl Acad Sci U S A, 2020 Jul 7. PMID 32571933, Free PMC Article
    2. The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number. Lavado A, et al. Dev Cell, 2018 Dec 3. PMID 30523785, Free PMC Article
    3. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article
    4. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. Suzuki T, et al. J Biol Chem, 2001 Aug 31. PMID 11402041
    5. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cell stemness is maintained upon concurrent expression of RB and the mitochondrial ribosomal protein S18-2.
      Title: Cell stemness is maintained upon concurrent expression of RB and the mitochondrial ribosomal protein S18-2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of mitochondrial small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein mS40
    Names
    28S ribosomal protein S18-2, mitochondrial
    28S ribosomal protein S18b, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347380.1 → NP_001334309.1  small ribosomal subunit protein mS40 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK076033, BP770625, DV649021
      Consensus CDS
      CCDS84307.1
      UniProtKB/TrEMBL
      Q542W5
      Related
      ENSMUSP00000109412.4, ENSMUST00000113782.10

    2. NM_001361453.1 → NP_001348382.1  small ribosomal subunit protein mS40 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CR974451
      UniProtKB/TrEMBL
      G3UYX8
      Related
      ENSMUSP00000134264.2, ENSMUST00000174349.8

    3. NM_001361454.1 → NP_001348383.1  small ribosomal subunit protein mS40 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CR974451

    4. NM_001361455.1 → NP_001348384.1  small ribosomal subunit protein mS40 isoform 5

      Status: VALIDATED

      Source sequence(s)
      CR974451
      UniProtKB/TrEMBL
      G3UX79
      Related
      ENSMUSP00000133584.2, ENSMUST00000174807.8
      Conserved Domains (1) summary
      cl00373
      Location:109 → 139
      Ribosomal_S18; Ribosomal protein S18

    5. NM_025878.2 → NP_080154.1  small ribosomal subunit protein mS40 isoform 1

      See identical proteins and their annotated locations for NP_080154.1

      Status: VALIDATED

      Source sequence(s)
      CR974451
      Consensus CDS
      CCDS28712.1
      UniProtKB/Swiss-Prot
      Q3TLA9, Q99N84, Q9CRK0, Q9DCR8
      UniProtKB/TrEMBL
      Q3THT9, Q3TKB7
      Related
      ENSMUSP00000025305.10, ENSMUST00000025305.16
      Conserved Domains (1) summary
      pfam01084
      Location:109 → 161
      Ribosomal_S18; Ribosomal protein S18

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      36221272..36227332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160747.1 → XP_036016640.1  small ribosomal subunit protein mS40 isoform X1

      Conserved Domains (1) summary
      pfam01084
      Location:22 → 67
      Ribosomal_S18; Ribosomal protein S18
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99N84.1 GenPept UniProtKB/Swiss-Prot:Q99N84

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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