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    Gmpr guanosine monophosphate reductase [ Mus musculus (house mouse) ]

    Gene ID: 66355, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gmprprovided by MGI
    Official Full Name
    guanosine monophosphate reductaseprovided by MGI
    Primary source
    MGI:MGI:1913605
    See related
    Ensembl:ENSMUSG00000000253 AllianceGenome:MGI:1913605
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GMPR 1; 2310004P21Rik
    Summary
    A similar gene in human encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides. [provided by RefSeq, May 2015]
    Expression
    Broad expression in liver E14 (RPKM 82.5), liver E14.5 (RPKM 79.8) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 A5; 13 21.94 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (45660905..45699862)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (45507428..45546386)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1462 Neighboring gene STARR-seq mESC enhancer starr_34393 Neighboring gene STARR-positive B cell enhancer ABC_E5392 Neighboring gene myosin regulatory light chain interacting protein Neighboring gene predicted gene, 53792 Neighboring gene STARR-positive B cell enhancer ABC_E7232 Neighboring gene STARR-seq mESC enhancer starr_34395 Neighboring gene predicted gene, 34582 Neighboring gene ataxin 1 Neighboring gene STARR-positive B cell enhancer mm9_chr13:45744500-45744801 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:45789016-45789125 Neighboring gene STARR-seq mESC enhancer starr_34397 Neighboring gene STARR-seq mESC enhancer starr_34398 Neighboring gene STARR-positive B cell enhancer mm9_chr13:45980000-45980300 Neighboring gene STARR-seq mESC enhancer starr_34399 Neighboring gene STARR-positive B cell enhancer mm9_chr13:46017736-46018037 Neighboring gene RIKEN cDNA 5033430I15 gene Neighboring gene STARR-positive B cell enhancer mm9_chr13:46060268-46060569

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The dynamic determinants of reaction specificity in the IMPDH/GMPR family of (β/α)(8) barrel enzymes. Hedstrom L. Crit Rev Biochem Mol Biol, 2012 May-Jun. PMID 22332716, Free PMC Article
    2. Guanosine 5'-phosphate reductase and its role in the interconversion of purine nucleotides. MAGER J, et al. J Biol Chem, 1960 May. PMID 14419794
    3. In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord. Lai HC, et al. J Neurosci, 2011 Jul 27. PMID 21795538, Free PMC Article
    4. Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis. Pang CJ, et al. Mol Cell Biol, 2012 Jul. PMID 22566683, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GMP reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in IMP salvage ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine nucleobase metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GMP reductase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GMP reductase 1
    Names
    guanosine 5'-monophosphate oxidoreductase 1
    guanosine monophosphate reductase 1
    NP_079784.1
    XP_017171050.1
    XP_017171051.1
    XP_030103212.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025508.5 → NP_079784.1  GMP reductase 1

      See identical proteins and their annotated locations for NP_079784.1

      Status: REVIEWED

      Source sequence(s)
      AC154521, AC154817, AK084508, BY274415
      Consensus CDS
      CCDS26482.1
      UniProtKB/Swiss-Prot
      Q9DCZ1
      Related
      ENSMUSP00000000260.6, ENSMUST00000000260.13
      Conserved Domains (2) summary
      TIGR01305
      Location:3 → 344
      GMP_reduct_1; guanosine monophosphate reductase, eukaryotic
      cd00381
      Location:10 → 336
      IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      45660905..45699862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247352.2 → XP_030103212.1  GMP reductase 1 isoform X1

      Conserved Domains (1) summary
      PRK05096
      Location:3 → 393
      PRK05096; guanosine 5'-monophosphate oxidoreductase; Provisional

    2. XM_017315562.1 → XP_017171051.1  GMP reductase 1 isoform X3

      UniProtKB/TrEMBL
      F6VY18
      Conserved Domains (1) summary
      TIGR01305
      Location:1 → 290
      GMP_reduct_1; guanosine monophosphate reductase, eukaryotic

    3. XM_017315561.1 → XP_017171050.1  GMP reductase 1 isoform X2

      Conserved Domains (1) summary
      PRK05096
      Location:30 → 278
      PRK05096; guanosine 5'-monophosphate oxidoreductase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCZ1.1 GenPept UniProtKB/Swiss-Prot:Q9DCZ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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