U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Tipin timeless interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 66131, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tipinprovided by MGI
    Official Full Name
    timeless interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1921571
    See related
    Ensembl:ENSMUSG00000032397 AllianceGenome:MGI:1921571
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110005A05Rik; 1110018P21Rik
    Summary
    The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM and aids in protecting cells against DNA damage and stress. [provided by RefSeq, Feb 2014]
    Expression
    Biased expression in liver E14 (RPKM 28.2), CNS E11.5 (RPKM 20.3) and 13 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    9 C; 9 34.6 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64188776..64212704)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64281491..64305422)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:64027060-64027169 Neighboring gene STARR-seq mESC enhancer starr_24421 Neighboring gene STARR-seq mESC enhancer starr_24422 Neighboring gene STARR-seq mESC enhancer starr_24424 Neighboring gene small nuclear RNA activating complex, polypeptide 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:64075662-64075771 Neighboring gene mitogen-activated protein kinase kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E8856 Neighboring gene STARR-positive B cell enhancer ABC_E2293 Neighboring gene STARR-seq mESC enhancer starr_24425 Neighboring gene STARR-seq mESC enhancer starr_24427 Neighboring gene STARR-positive B cell enhancer ABC_E6754 Neighboring gene ubiquitin carboxyl-terminal esterase L4 Neighboring gene STARR-seq mESC enhancer starr_24428 Neighboring gene predicted gene, 24289 Neighboring gene DIS3 like exosome 3'-5' exoribonuclease Neighboring gene STARR-seq mESC enhancer starr_24432 Neighboring gene STARR-seq mESC enhancer starr_24433 Neighboring gene multiple EGF-like-domains 11 Neighboring gene STARR-seq mESC enhancer starr_24435 Neighboring gene STARR-positive B cell enhancer mm9_chr9:64519558-64519858 Neighboring gene predicted gene, 36311

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cardiac physiologic and genetic predictors of hyperoxia-induced acute lung injury in mice. Howden R, et al. Am J Respir Cell Mol Biol, 2012 Apr. PMID 22052878, Free PMC Article
    2. Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis. Smith KD, et al. J Cell Biol, 2009 Oct 5. PMID 19805627, Free PMC Article
    3. Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association. Gotter AL. J Mol Biol, 2003 Aug 1. PMID 12875843
    4. Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors. Gotter AL, et al. J Mol Biol, 2007 Feb 9. PMID 17141802, Free PMC Article
    5. CUL2(LRR1) , TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle. Villa F, et al. EMBO Rep, 2021 Mar 3. PMID 33590678, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis.
      Title: Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis.
    2. mTIM promotes the nuclear localization of TIPIN, and TIPIN is capable of regulating mTIM activity by disrupting the ability of mTIM to form homo-multimeric complexes
      Title: Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association.
    3. TIM and Tipin are functional orthologs of their replisome-associated yeast counterparts capable of coordinating replication with genotoxic stress responses, and distinguishes mammalian TIM from the circadian-specific paralogs.
      Title: Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replication fork arrest IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of replication fork protection complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    TIMELESS-interacting protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324556.1 → NP_001311485.1  TIMELESS-interacting protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK038111, BF463598, CJ082457
      Consensus CDS
      CCDS23279.1
      UniProtKB/Swiss-Prot
      Q91WA1, Q9CQM3, Q9D1J4
      Conserved Domains (1) summary
      pfam07962
      Location:63 → 145
      Swi3; Replication Fork Protection Component Swi3

    2. NM_001324557.1 → NP_001311486.1  TIMELESS-interacting protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK011357, AK038111, CJ082457
      Consensus CDS
      CCDS23279.1
      UniProtKB/Swiss-Prot
      Q91WA1, Q9CQM3, Q9D1J4
      Conserved Domains (1) summary
      pfam07962
      Location:63 → 145
      Swi3; Replication Fork Protection Component Swi3

    3. NM_001324558.1 → NP_001311487.1  TIMELESS-interacting protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK038111, CJ082457
      Consensus CDS
      CCDS23279.1
      UniProtKB/Swiss-Prot
      Q91WA1, Q9CQM3, Q9D1J4
      Related
      ENSMUSP00000149833.2, ENSMUST00000216594.2
      Conserved Domains (1) summary
      pfam07962
      Location:63 → 145
      Swi3; Replication Fork Protection Component Swi3

    4. NM_025372.4 → NP_079648.1  TIMELESS-interacting protein

      See identical proteins and their annotated locations for NP_079648.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK003802, AK038111, CJ082457
      Consensus CDS
      CCDS23279.1
      UniProtKB/Swiss-Prot
      Q91WA1, Q9CQM3, Q9D1J4
      Related
      ENSMUSP00000034964.7, ENSMUST00000034964.7
      Conserved Domains (1) summary
      pfam07962
      Location:63 → 145
      Swi3; Replication Fork Protection Component Swi3

    RNA

    1. NR_136926.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK038111, CA321902, CJ082457

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      64188776..64212704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244490.2 → XP_030100350.1  TIMELESS-interacting protein isoform X2

      Conserved Domains (1) summary
      pfam07962
      Location:1 → 42
      Swi3; Replication Fork Protection Component Swi3

    2. XM_030244491.2 → XP_030100351.1  TIMELESS-interacting protein isoform X2

      Conserved Domains (1) summary
      pfam07962
      Location:1 → 42
      Swi3; Replication Fork Protection Component Swi3

    3. XM_030244489.2 → XP_030100349.1  TIMELESS-interacting protein isoform X2

      Conserved Domains (1) summary
      pfam07962
      Location:1 → 42
      Swi3; Replication Fork Protection Component Swi3

    4. XM_006511340.4 → XP_006511403.1  TIMELESS-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_006511403.1

      UniProtKB/Swiss-Prot
      Q91WA1, Q9CQM3, Q9D1J4
      Conserved Domains (1) summary
      pfam07962
      Location:63 → 145
      Swi3; Replication Fork Protection Component Swi3

    RNA

    1. XR_003947967.2 RNA Sequence

    2. XR_003947966.2 RNA Sequence

    3. XR_001778960.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WA1.2 GenPept UniProtKB/Swiss-Prot:Q91WA1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous