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    Elof1 ELF1 homolog, elongation factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 66126, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Elof1provided by MGI
    Official Full Name
    ELF1 homolog, elongation factor 1provided by MGI
    Primary source
    MGI:MGI:1913376
    See related
    Ensembl:ENSMUSG00000013822 AllianceGenome:MGI:1913376
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110011K10Rik
    Summary
    Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in transcription elongation from RNA polymerase II promoter. Predicted to be located in nucleus. Predicted to be part of transcription elongation factor complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and immune system. Orthologous to human ELOF1 (elongation factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 245.4), ovary adult (RPKM 51.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A3; 9 8.34 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (22024282..22028491, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (22112986..22117195, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6581 Neighboring gene calponin 1 Neighboring gene microRNA 7084 Neighboring gene STARR-positive B cell enhancer ABC_E2285 Neighboring gene STARR-positive B cell enhancer ABC_E11403 Neighboring gene acid phosphatase 5, tartrate resistant Neighboring gene predicted gene, 39306

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The elongation factor Elof1 is required for mammalian gastrulation. Tellier AP, et al. PLoS One, 2019. PMID 31276560, Free PMC Article
    2. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    3. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription elongation factor 1 homolog
    Names
    elongation factor 1 homolog (ELF1, S. cerevisiae)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357309.1 → NP_001344238.1  transcription elongation factor 1 homolog

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
      Source sequence(s)
      AC163623, BU583434
      Consensus CDS
      CCDS40559.1
      UniProtKB/Swiss-Prot
      P60003
      UniProtKB/TrEMBL
      Q545S6
      Related
      ENSMUSP00000150169.2, ENSMUST00000213233.2
      Conserved Domains (1) summary
      pfam05129
      Location:20 → 80
      Elf1; Transcription elongation factor Elf1 like

    2. NM_001357310.1 → NP_001344239.1  transcription elongation factor 1 homolog

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
      Source sequence(s)
      AC163623, DV649291
      Consensus CDS
      CCDS40559.1
      UniProtKB/Swiss-Prot
      P60003
      UniProtKB/TrEMBL
      Q545S6
      Conserved Domains (1) summary
      pfam05129
      Location:20 → 80
      Elf1; Transcription elongation factor Elf1 like

    3. NM_001357311.1 → NP_001344240.1  transcription elongation factor 1 homolog

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
      Source sequence(s)
      AC163623, AK003614
      Consensus CDS
      CCDS40559.1
      UniProtKB/Swiss-Prot
      P60003
      UniProtKB/TrEMBL
      Q545S6
      Related
      ENSMUSP00000013966.7, ENSMUST00000013966.8
      Conserved Domains (1) summary
      pfam05129
      Location:20 → 80
      Elf1; Transcription elongation factor Elf1 like

    4. NM_001357312.1 → NP_001344241.1  transcription elongation factor 1 homolog

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
      Source sequence(s)
      AC163623
      Consensus CDS
      CCDS40559.1
      UniProtKB/Swiss-Prot
      P60003
      UniProtKB/TrEMBL
      Q545S6
      Conserved Domains (1) summary
      pfam05129
      Location:20 → 80
      Elf1; Transcription elongation factor Elf1 like

    5. NM_001357313.1 → NP_001344242.1  transcription elongation factor 1 homolog

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
      Source sequence(s)
      AC163623
      Consensus CDS
      CCDS40559.1
      UniProtKB/Swiss-Prot
      P60003
      UniProtKB/TrEMBL
      Q545S6
      Related
      ENSMUSP00000150536.2, ENSMUST00000214394.2
      Conserved Domains (1) summary
      pfam05129
      Location:20 → 80
      Elf1; Transcription elongation factor Elf1 like

    6. NM_001357314.1 → NP_001344243.1  transcription elongation factor 1 homolog

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
      Source sequence(s)
      AC163623
      Consensus CDS
      CCDS40559.1
      UniProtKB/Swiss-Prot
      P60003
      UniProtKB/TrEMBL
      Q545S6
      Conserved Domains (1) summary
      pfam05129
      Location:20 → 80
      Elf1; Transcription elongation factor Elf1 like

    7. NM_170777.4 → NP_740747.1  transcription elongation factor 1 homolog

      See identical proteins and their annotated locations for NP_740747.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All seven variants encode the same protein.
      Source sequence(s)
      AC163623
      Consensus CDS
      CCDS40559.1
      UniProtKB/Swiss-Prot
      P60003
      UniProtKB/TrEMBL
      Q545S6
      Related
      ENSMUSP00000128173.2, ENSMUST00000166335.2
      Conserved Domains (1) summary
      pfam05129
      Location:20 → 80
      Elf1; Transcription elongation factor Elf1 like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      22024282..22028491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60003.1 GenPept UniProtKB/Swiss-Prot:P60003

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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