Aldh4a1 aldehyde dehydrogenase 4 family, member A1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aldh4a1provided by RGD
Official Full Name: aldehyde dehydrogenase 4 family, member A1provided by RGD
Primary source: RGD:1624206
See related: Ensembl:ENSRNOG00000061876 AllianceGenome:RGD:1624206
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable 1-pyrroline-5-carboxylate dehydrogenase activity; aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to be located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 708.9), Kidney (RPKM 680.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (157163189..157188673)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (151880002..151905491)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (158090238..158115725)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-pyrroline-5-carboxylate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-pyrroline-5-carboxylate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables 1-pyrroline-5-carboxylate dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables aldehyde dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in proline catabolic process to glutamate	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

Names: L-glutamate gamma-semialdehyde dehydrogenase; P5C dehydrogenase; aldehyde dehydrogenase family 4 member A1

NP_001128170.1

EC 1.2.1.88

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134698.1 → NP_001128170.1 delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

See identical proteins and their annotated locations for NP_001128170.1

Status: PROVISIONAL

Source sequence(s)

BC168153

UniProtKB/TrEMBL

A6ITM7, B4F768

Related

ENSRNOP00000069536.2, ENSRNOT00000079516.2

Conserved Domains (1) summary

cd07123
Location:31 → 552

ALDH_F4-17_P5CDH; Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17