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    CREBZF CREB/ATF bZIP transcription factor [ Homo sapiens (human) ]

    Gene ID: 58487, updated on 22-Apr-2024

    Summary

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    Official Symbol
    CREBZFprovided by HGNC
    Official Full Name
    CREB/ATF bZIP transcription factorprovided by HGNC
    Primary source
    HGNC:HGNC:24905
    See related
    Ensembl:ENSG00000137504 MIM:606444; AllianceGenome:HGNC:24905
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZF; SMILE
    Summary
    Enables identical protein binding activity. Involved in negative regulation of gene expression, epigenetic; regulation of transcription, DNA-templated; and response to virus. Located in mitochondrion and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in endometrium (RPKM 18.3), spleen (RPKM 18.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    11q14.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (85657990..85682863, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (85594499..85619547, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (85369034..85393906, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5365 Neighboring gene transmembrane protein 126B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5367 Neighboring gene transmembrane protein 126A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5368 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:85383205-85383705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:85396033-85396534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:85396535-85397034 Neighboring gene coiled-coil domain containing 89 Neighboring gene synaptotagmin like 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:85472379-85473578 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3822

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Mechanism for the induction of cell death in ONS-76 medulloblastoma cells by Zhangfei/CREB-ZF. Bodnarchuk TW, et al. J Neurooncol, 2012 Sep. PMID 22798206
    2. SMILE silencing and PMA activation gene networks in HeLa cells: comparison with kidney transplantation gene networks. Racapé M, et al. J Cell Biochem, 2012 Jun. PMID 22134986
    3. Zhangfei, a novel regulator of the human nerve growth factor receptor, trkA. Valderrama X, et al. J Neurovirol, 2008 Oct. PMID 19016376
    4. The neuronal host cell factor-binding protein Zhangfei inhibits herpes simplex virus replication. Akhova O, et al. J Virol, 2005 Dec. PMID 16282471, Free PMC Article
    5. SMILE Downregulation during Melanogenesis Induces MITF Transcription in B16F10 Cells. Truong XT, et al. Int J Mol Sci, 2022 Dec 1. PMID 36499416, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Macrophage CREBZF Orchestrates Inflammatory Response to Potentiate Insulin Resistance and Type 2 Diabetes.
      Title: Macrophage CREBZF Orchestrates Inflammatory Response to Potentiate Insulin Resistance and Type 2 Diabetes.
    2. When molecular outsmarts morphology: Malignant ossifying fibromyxoid tumors masquerading as osteosarcomas, including a novel CREBZF::PHF1 fusion.
      Title: When molecular outsmarts morphology: Malignant ossifying fibromyxoid tumors masquerading as osteosarcomas, including a novel CREBZF::PHF1 fusion.
    3. Intrahepatic osteopontin signaling by CREBZF defines a checkpoint for steatosis-to-NASH progression.
      Title: Intrahepatic osteopontin signaling by CREBZF defines a checkpoint for steatosis-to-NASH progression.
    4. SMILE Downregulation during Melanogenesis Induces MITF Transcription in B16F10 Cells.
      Title: SMILE Downregulation during Melanogenesis Induces MITF Transcription in B16F10 Cells.
    5. Up-regulation of long noncoding RNA MBNL1-AS1 suppresses breast cancer progression by modulating miR-423-5p/CREBZF axis.
      Title: Up-regulation of long noncoding RNA MBNL1-AS1 suppresses breast cancer progression by modulating miR-423-5p/CREBZF axis.
    6. miRNAs as potential biomarkers for the progression of gastric cancer inhibit CREBZF and regulate migration of gastric adenocarcinoma cells.
      Title: miRNAs as potential biomarkers for the progression of gastric cancer inhibit CREBZF and regulate migration of gastric adenocarcinoma cells.
    7. Zhangfei/CREBZF stabilizes p53 and co-localizes with it in cellular nuclei; the bLZip domain of Zhangfei is required for its profound effects on cell growth and interaction with p53.
      Title: Effects of cyclic AMP response element binding protein-Zhangfei (CREBZF) on the unfolded protein response and cell growth are exerted through the tumor suppressor p53.
    8. Zhangfei had a suppressive effect on most unfolded protein response genes.
      Title: Zhangfei/CREB-ZF - a potential regulator of the unfolded protein response.
    9. Results indicate that Ursodeoxycholic acid (UDCA) activates SMILE gene expression, which leads to repression of liver X receptor alpha (LXRalpha)-mediated hepatic lipogenic enzyme gene expression.
      Title: Ursodeoxycholic acid inhibits liver X receptor α-mediated hepatic lipogenesis via induction of the nuclear corepressor SMILE.
    10. Our objective was to determine the molecular mechanisms by which Zhangfei influences medulloblastoma cell lines
      Title: Mechanism for the induction of cell death in ONS-76 medulloblastoma cells by Zhangfei/CREB-ZF.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ94018

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATF6-mediated unfolded protein response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in integrated stress response signaling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression, epigenetic IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CREB/ATF bZIP transcription factor
    Names
    HCF-binding transcription factor Zhangfei
    SHP-interacting leucine zipper protein
    Zhangfei
    host cell factor-binding transcription factor Zhangfei
    small heterodimer partner-interacting leucine zipper

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039618.4 → NP_001034707.1  CREB/ATF bZIP transcription factor

      See identical proteins and their annotated locations for NP_001034707.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
      Source sequence(s)
      AP000642
      Consensus CDS
      CCDS41697.1
      UniProtKB/Swiss-Prot
      B2R8Q9, Q0P5U9, Q52LT3, Q9NS37
      Related
      ENSP00000433459.1, ENST00000527447.2
      Conserved Domains (1) summary
      cl21462
      Location:219 → 260
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    RNA

    1. NR_028024.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AP000642

    2. NR_028025.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AP000642

    3. NR_028026.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks three alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AP000642

    4. NR_028027.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks four alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AP000642

    5. NR_165399.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642

    6. NR_165400.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642, KF511165

    7. NR_165401.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642, KF511165

    8. NR_165402.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642

    9. NR_165403.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642

    10. NR_165404.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642

    11. NR_165405.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642

    12. NR_165406.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642

    13. NR_165407.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642

    14. NR_165408.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642

    15. NR_165409.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642

    16. NR_165410.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642

    17. NR_165411.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      85657990..85682863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018086.2 → XP_016873575.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0
      Conserved Domains (1) summary
      cl21462
      Location:219 → 260
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    2. XM_047427377.1 → XP_047283333.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0

    3. XM_047427378.1 → XP_047283334.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0
      Related
      ENSP00000507358.1, ENST00000682836.1

    4. XM_047427376.1 → XP_047283332.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0

    5. XM_047427375.1 → XP_047283331.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0

    6. XM_017018090.2 → XP_016873579.1  CREB/ATF bZIP transcription factor isoform X2

      UniProtKB/Swiss-Prot
      B2R8Q9, Q0P5U9, Q52LT3, Q9NS37
      Conserved Domains (1) summary
      cl21462
      Location:219 → 260
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    7. XM_047427379.1 → XP_047283335.1  CREB/ATF bZIP transcription factor isoform X2

      UniProtKB/Swiss-Prot
      B2R8Q9, Q0P5U9, Q52LT3, Q9NS37

    8. XM_017018088.2 → XP_016873577.1  CREB/ATF bZIP transcription factor isoform X2

      UniProtKB/Swiss-Prot
      B2R8Q9, Q0P5U9, Q52LT3, Q9NS37
      Conserved Domains (1) summary
      cl21462
      Location:219 → 260
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    9. XM_017018089.2 → XP_016873578.1  CREB/ATF bZIP transcription factor isoform X2

      UniProtKB/Swiss-Prot
      B2R8Q9, Q0P5U9, Q52LT3, Q9NS37
      Conserved Domains (1) summary
      cl21462
      Location:219 → 260
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    10. XM_006718642.4 → XP_006718705.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0
      Related
      ENSP00000435762.1, ENST00000525639.1
      Conserved Domains (1) summary
      cl21462
      Location:219 → 260
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    11. XM_011545195.3 → XP_011543497.1  CREB/ATF bZIP transcription factor isoform X2

      See identical proteins and their annotated locations for XP_011543497.1

      UniProtKB/Swiss-Prot
      B2R8Q9, Q0P5U9, Q52LT3, Q9NS37
      Related
      ENSP00000434281.1, ENST00000490820.2
      Conserved Domains (1) summary
      cl21462
      Location:219 → 260
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      85594499..85619547 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369568.1 → XP_054225543.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0

    2. XM_054369567.1 → XP_054225542.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0

    3. XM_054369574.1 → XP_054225549.1  CREB/ATF bZIP transcription factor isoform X2

      UniProtKB/Swiss-Prot
      B2R8Q9, Q0P5U9, Q52LT3, Q9NS37

    4. XM_054369571.1 → XP_054225546.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0

    5. XM_054369572.1 → XP_054225547.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0

    6. XM_054369573.1 → XP_054225548.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0

    7. XM_054369570.1 → XP_054225545.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0

    8. XM_054369569.1 → XP_054225544.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0

    9. XM_054369575.1 → XP_054225550.1  CREB/ATF bZIP transcription factor isoform X2

      UniProtKB/Swiss-Prot
      B2R8Q9, Q0P5U9, Q52LT3, Q9NS37

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_021212.1: Suppressed sequence

      Description
      NM_021212.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NS37.2 GenPept UniProtKB/Swiss-Prot:Q9NS37

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