PTGDR prostaglandin D2 receptor (DP) [Homo sapiens (human)] - Gene

Summary

Go to the top of the page Help

Official Symbol: PTGDRprovided by HGNC
Official Full Name: prostaglandin D2 receptor (DP)provided by HGNC
Primary source: HGNC:9591
See related: Ensembl:ENSG00000168229; HPRD:05254; MIM:604687; Vega:OTTHUMG00000140299
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DP; AS1; DP1; ASRT1; PTGDR1
Summary: The protein encoded by this gene is a G-protein-coupled receptor. It has been shown to function as a prostanoid DP receptor. The activity of this receptor is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+. Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses. [provided by RefSeq, Jul 2008]

Genomic context

Go to the top of the page Help

Location :: 14q22.1

Sequence :: Chromosome: 14; NC_000014.8 (52734431..52743442)

See PTGDR in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PGD(2)-DP signaling reduces vascular permeability via endothelial cAMP/PKA/Tiam1/Rac1 pathway.
Title: Prostaglandin D2-DP signaling promotes endothelial barrier function via the cAMP/PKA/Tiam1/Rac1 pathway.
The PTGDR -441C/T polymorphism is not associated with asthma or its phenotypes in the North Indian population.
Title: No association of PTGDR -441C/T polymorphism with asthma in a North Indian population.
DP receptors amplify the biological response to CRTH2 activation and the CRTH2/DP heteromer might represent both a functional signaling unit for PGD(2) and a potential target for development of heteromer-directed therapy for allergic diseases
Title: D-type prostanoid receptor enhances the signaling of chemoattractant receptor-homologous molecule expressed on T(H)2 cells.
Genetic combinations described have functional implications in the PTGDR promoter activity by changing the transcription factors affinity that will help characterize different risk groups.
Title: PTGDR gene in asthma: a functional, genetic, and epigenetic study.
PGD(2) can induce MUC5B overproduction via ERK MAPK/RSK1/CREB signaling and that DP1 receptor may have suppressive effects in controlling MUC5B overproduction in the airway.
Title: The extracellular signal-regulated kinase mitogen-activated protein kinase/ribosomal S6 protein kinase 1 cascade phosphorylates cAMP response element-binding protein to induce MUC5B gene expression via D-prostanoid receptor signaling.
Polymorphisms of the PTGDR and LTC4S influence responsiveness to leukotriene receptor antagonists in Korean children with asthma.
Title: Polymorphisms of the PTGDR and LTC4S influence responsiveness to leukotriene receptor antagonists in Korean children with asthma.
DP mediates eosinophils through the elevation of intracellular cAMP production but does not change CRTH2 expression; balance between DP and CRTH2 could influence the degree of PGD2-induced eosinophil migration
Title: The opposing role of two prostaglandin D2 receptors, DP and CRTH2, in human eosinophil migration.
during allergen-elicited eosinophilic inflammatory reactions, cysteinyl-leukotriene production is regulated by DP1/DP2-orchestrated eosinophil activation
Title: Co-operative signalling through DP(1) and DP(2) prostanoid receptors is required to enhance leukotriene C(4) synthesis induced by prostaglandin D(2) in eosinophils.
DP(1) receptors coupled to G(alphas) increase adenylate cyclase activity and cAMP/protein kinase A-dependent formation of lipid bodies, and DP(2) receptors coupled to G(alphai) increase calcium; each of these signals is required for LTC(4) production
Title: R2D(2) for C(4)Eo: an 'alliance' of PGD(2) receptors is required for LTC(4) production by human eosinophils.
These results suggest that despite the non-significant findings in the present study populations, prostanoid D2 receptor promoter haplotypes may account for a small but significant proportion of the risk of asthma in Caucasian populations.
Title: Functional haplotypes in the PTGDR gene fail to associate with asthma in two Australian populations.

Submit: New GeneRIF Correction See all (37)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 1

MIM: 607277

Genetic Testing Registry

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Source	Pubs	Description
Q13258	Q5JWF2	GNAS	HPRD	PubMed
BioGRID:111701	BioGRID:123534	ANKRD13C	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:111701	BioGRID:106848	APP	BioGRID	PubMed	Reconstituted Complex

Pathways from BioSystems

Go to the top of the page Help

Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
Eicosanoid ligand-binding receptors, organism-specific biosystem (from REACTOME)
Eicosanoid ligand-binding receptors, organism-specific biosystemEicosanoids, derived from polyunsaturated 20-carbon fatty acids, are paracrine and autocrine regulators of inflammation, smooth muscle contraction, and blood coagulation. The actions of eicosanoids a...
G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
Neuroactive ligand-receptor interaction, organism-specific biosystem
Neuroactive ligand-receptor interaction
Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
Neuroactive ligand-receptor interaction, conserved biosystem
Neuroactive ligand-receptor interaction
Prostaglandin Synthesis and Regulation, organism-specific biosystem (from WikiPathways)
Prostaglandin Synthesis and Regulation, organism-specific biosystem
Prostaglandin Synthesis and Regulation
Prostanoid ligand receptors, organism-specific biosystem (from REACTOME)
Prostanoid ligand receptors, organism-specific biosystemFatty acid cyclo-oxygenase (COX) converts arachidonic acid to prostaglandin H2 (PGH2) from which the prostanoids PGD2, PGE2, PGF2alpha, PGI2 (prostacyclin) and thromboxane A2 (TXA2) are derived. Base...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Small Ligand GPCRs, organism-specific biosystem (from WikiPathways)
Small Ligand GPCRs, organism-specific biosystem
Small Ligand GPCRs
Thromboxane A2 receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
Thromboxane A2 receptor signaling, organism-specific biosystem
Thromboxane A2 receptor signaling

General gene information

Go to the top of the page Help

Markers

RH71220 (e-PCR)
- UniSTS:52349

RH92017 (e-PCR)
- UniSTS:89497

D14S588 (e-PCR), detects polymorphism
- UniSTS:48836

PMC58788P1 (e-PCR)
- UniSTS:273373

D14S603 (e-PCR), detects polymorphism
- UniSTS:47346

Genotypes

See PTGDR SNP Geneview Report
See PTGDR SNP Genotype Report
See PTGDR SNP Variation Viewer Report

Homology

Homologs of the PTGDR gene: The PTGDR gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
prostaglandin D receptor activity	NAS Non-traceable Author Statement more info	PubMed
prostaglandin J receptor activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info

Process	Evidence Code	Pubs
G-protein coupled receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
adenosine metabolic process	IEA Inferred from Electronic Annotation more info
cellular response to prostaglandin D stimulus	IEA Inferred from Electronic Annotation more info
inflammatory response	IEA Inferred from Electronic Annotation more info
male sex determination	IEA Inferred from Electronic Annotation more info
sleep	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
integral to membrane	NAS Non-traceable Author Statement more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info
plasma membrane	TAS Traceable Author Statement more info

General protein information

Go to the top of the page Help

Preferred Names: prostaglandin D2 receptor

Names: prostaglandin D2 receptor; PGD receptor; PGD2 receptor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012118.1 RefSeqGene

Range

5001..14012

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000953.2 → NP_000944.1 prostaglandin D2 receptor

Status: REVIEWED

Source sequence(s)

AK026202, BC040968

Consensus CDS

CCDS9707.1

UniProtKB/Swiss-Prot

Q13258

Related

ENSP00000303424, OTTHUMP00000178986, ENST00000306051, OTTHUMT00000276889

Conserved Domains (1) summary

pfam00001
Location:55 – 190
Blast Score: 175

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p10 Primary Assembly

Range

52734431..52743442

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

32895105..32904115

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018925.1 Alternate CHM1_1.0

Range

33717826..33726838

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01018165.1 (39296..48306)	None
genomic	AL365475.1 (95060..104071)	None
genomic	AMYH01005730.1 (137306..146318)	None
genomic	CH471078.2	EAW65657.1
genomic	DQ418808.1	ABD72608.1
genomic	U31098.1	AAC50176.1
genomic	U31332.1	AAC50178.1
mRNA	AK026202.1	None
mRNA	BC040968.1	AAH40968.1
mRNA	EF577397.1	ABQ52417.1
mRNA	U31099.1	AAC50177.1