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    PTGDR prostaglandin D2 receptor [ Homo sapiens (human) ]

    Gene ID: 5729, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PTGDRprovided by HGNC
    Official Full Name
    prostaglandin D2 receptorprovided by HGNC
    Primary source
    HGNC:HGNC:9591
    See related
    Ensembl:ENSG00000168229 MIM:604687; AllianceGenome:HGNC:9591
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DP; AS1; DP1; ASRT1; PTGDR1
    Summary
    This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
    Expression
    Broad expression in spleen (RPKM 1.6), colon (RPKM 1.3) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    14q22.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (52267698..52280914)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (46474808..46488025)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (52734416..52743442)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378180 Neighboring gene CAGE-defined high expression enhancer upstream of NID2 Neighboring gene long intergenic non-protein coding RNA 2319 Neighboring gene cytochrome c oxidase subunit 5A pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:52622695-52623194 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:52674645-52675844 Neighboring gene pumilio domain-containing protein KIAA0020-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:52780260-52780820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:52780821-52781380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8387 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8389 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8390 Neighboring gene prostaglandin E receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Promoter Genotyping and mRNA Expression - Based Analysis of the PTGDR Gene in Allergy. San Segundo-Val I, et al. J Investig Allergol Clin Immunol, 2020 Apr 24. PMID 31062691
    2. DP1 receptor signaling prevents the onset of intrinsic apoptosis in eosinophils and functions as a transcriptional modulator. Peinhaupt M, et al. J Leukoc Biol, 2018 Jul. PMID 29607536, Free PMC Article
    3. PTGDR gene expression and response to dexamethasone treatment in an in vitro model. Marcos-Vadillo E, et al. PLoS One, 2017. PMID 29088248, Free PMC Article
    4. Non-obligatory role of prostaglandin D2 receptor subtype 1 in rosacea: laropiprant in comparison to a placebo did not alleviate the symptoms of erythematoelangiectaic rosacea. Krishna R, et al. J Clin Pharmacol, 2015 Feb. PMID 25142778
    5. PTGDR polymorphisms and susceptibility to asthma: a meta-analysis. Lee YH, et al. Mol Biol Rep, 2013 Mar. PMID 23192614

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ASH1L-AS1-ASH1L axis controls NME1-mediated activation of the RAS signaling in gastric cancer.
      Title: The ASH1L-AS1-ASH1L axis controls NME1-mediated activation of the RAS signaling in gastric cancer.
    2. ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and inflammation by regulating miR-23a-3p/TLR4 axis.
      Title: ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and inflammation by regulating miR-23a-3p/TLR4 axis.
    3. High PGD2 receptor 2 levels are associated with poor prognosis in colorectal cancer patients and induce VEGF expression in colon cancer cells and migration in a zebrafish xenograft model.
      Title: High PGD(2) receptor 2 levels are associated with poor prognosis in colorectal cancer patients and induce VEGF expression in colon cancer cells and migration in a zebrafish xenograft model.
    4. GGA3 interacts with L-type prostaglandin D synthase and regulates the recycling and signaling of the DP1 receptor for prostaglandin D2 in a Rab4-dependent mechanism.
      Title: GGA3 interacts with L-type prostaglandin D synthase and regulates the recycling and signaling of the DP1 receptor for prostaglandin D(2) in a Rab4-dependent mechanism.
    5. Promoter Genotyping and mRNA Expression - Based Analysis of the PTGDR Gene in Allergy.
      Title: Promoter Genotyping and mRNA Expression - Based Analysis of the PTGDR Gene in Allergy.
    6. Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling.
      Title: Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling.
    7. -type prostaglandin D synthase regulates the trafficking of the PGD2 DP1 receptor by interacting with the GTPase Rab4
      Title: L-type prostaglandin D synthase regulates the trafficking of the PGD(2) DP1 receptor by interacting with the GTPase Rab4.
    8. We conclude that DP1 receptors promote the survival of eosinophils via serum response element induction and induction of pro-inflammatory genes
      Title: DP1 receptor signaling prevents the onset of intrinsic apoptosis in eosinophils and functions as a transcriptional modulator.
    9. PGD2 signaling through the D-prostanoid receptor 1 (DP1) receptor is necessary for optimal microglia/macrophage activation and IFN expression after infection with a neurotropic coronavirus
      Title: Virus-induced inflammasome activation is suppressed by prostaglandin D(2)/DP1 signaling.
    10. Polymorphisms of prostaglandin D receptor (PTGDR) gene influence basal promoter activity and gene expression, as well as the cytokine secretory pattern.
      Title: PTGDR gene expression and response to dexamethasone treatment in an in vitro model.
    Submit: New GeneRIF Correction See all GeneRIFs (56)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Asthma-related traits, susceptibility to, 1
    MedGen: C1846534 OMIM: 607277 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association studies and epistasis analyses of candidate genes related to age at menarche and age at natural menopause in a Korean population.
    EBI GWAS Catalog
    Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
    EBI GWAS Catalog
    Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC49004

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables prostaglandin D receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prostaglandin D receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables prostaglandin J receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in adenosine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to prostaglandin D stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male sex determination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sleep IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    prostaglandin D2 receptor
    Names
    PGD2 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012118.2 RefSeqGene

      Range
      5002..14028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000953.3 → NP_000944.1  prostaglandin D2 receptor isoform 1

      See identical proteins and their annotated locations for NP_000944.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK026202, AL365475, BC040968
      Consensus CDS
      CCDS9707.1
      UniProtKB/Swiss-Prot
      G3V5L3, Q13250, Q13251, Q13258, Q1ZZ52
      Related
      ENSP00000303424.2, ENST00000306051.3
      Conserved Domains (1) summary
      cd15140
      Location:17 → 335
      7tmA_PGD2; prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001281469.2 → NP_001268398.1  prostaglandin D2 receptor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK026202, AL365475, CD013871
      Consensus CDS
      CCDS61454.1
      UniProtKB/Swiss-Prot
      Q13258
      Related
      ENSP00000452408.1, ENST00000553372.1
      Conserved Domains (1) summary
      pfam00001
      Location:59 → 214
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      52267698..52280914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005267891.5 → XP_005267948.1  prostaglandin D2 receptor isoform X1

      See identical proteins and their annotated locations for XP_005267948.1

      UniProtKB/Swiss-Prot
      G3V5L3, Q13250, Q13251, Q13258, Q1ZZ52
      Conserved Domains (1) summary
      cd15140
      Location:17 → 335
      7tmA_PGD2; prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      46474808..46488025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376444.1 → XP_054232419.1  prostaglandin D2 receptor isoform X1

      UniProtKB/Swiss-Prot
      G3V5L3, Q13250, Q13251, Q13258, Q1ZZ52
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13258.2 GenPept UniProtKB/Swiss-Prot:Q13258

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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