bcl2a BCL2 apoptosis regulator a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bcl2aprovided by ZNC
Official Full Name: BCL2 apoptosis regulator aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-051012-1
See related: Ensembl:ENSDARG00000094704 AllianceGenome:ZFIN:ZDB-GENE-051012-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: bcl2
Summary: Enables protein heterodimerization activity. Acts upstream of or within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be located in endoplasmic reticulum membrane; mitochondrion; and nuclear membrane. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including anterior lateral mesoderm; corpuscles of Stannius; immature B cell; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; and prostate cancer. Orthologous to human BCL2 (BCL2 apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 24

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (28137210..28228917, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (28058051..28149758, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

upregulated in choriodecidua following labor
Title: Transcriptomic profiling of human choriodecidua during term labor: inflammation as a key driver of labor.
These results suggest a role for mitochondrial p53 activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax and Bcl2.
Title: Bax, Bcl2, and p53 differentially regulate neomycin- and gentamicin-induced hair cell death in the zebrafish lateral line.
Zebrafish gene expressions of P53, Bcl-2, Bax and caspase-3 were elevated after exposure with microcystin-LR under different ambient temperatures.
Title: Apoptotic responses of zebrafish (Danio rerio) after exposure with microcystin-LR under different ambient temperatures.
Analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1, and ICAM1 in human T-lymphoblastic lymphoma compared with T-lymphoblastic leukemia.
Title: T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.
Real-time RT-PCR revealed acetaminophen treatment of zebrafish embryos decreased the expression of cox2 and bcl2, but increased p53 expression.
Title: Nephrotoxicity assessments of acetaminophen during zebrafish embryogenesis.
Leukemia onset was dramatically accelerated in transgenic fish overexpressing human Notch1 and fish bcl-2, indicating synergy between the Notch pathway and the bcl2-mediated antiapoptotic pathway.
Title: NOTCH1-induced T-cell leukemia in transgenic zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables BH domain binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IBA Inferred from Biological aspect of Ancestor more info
NOT acts_upstream_of_or_within negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in release of cytochrome c from mitochondria	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: apoptosis regulator Bcl-2a

Names: B-cell CLL/lymphoma 2a; B-cell leukemia/lymphoma 2; B-cell leukemia/lymphoma 2a; zBlp2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030253.2 → NP_001025424.1 apoptosis regulator Bcl-2a

See identical proteins and their annotated locations for NP_001025424.1

Status: PROVISIONAL

Source sequence(s)

BC133848

UniProtKB/TrEMBL

A0A8N7XJI9, A3KNH9, F1QBA9, Q564A4

Related

ENSDARP00000120749.2, ENSDART00000145290.3

Conserved Domains (3) summary

cd06845
Location:65 → 190

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

TIGR00865
Location:9 → 192

bcl-2; apoptosis regulator

pfam02180
Location:6 → 30

BH4; Bcl-2 homology region 4