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    PLD2 phospholipase D2 [ Homo sapiens (human) ]

    Gene ID: 5338, updated on 26-May-2016
    Official Symbol
    PLD2provided by HGNC
    Official Full Name
    phospholipase D2provided by HGNC
    Primary source
    HGNC:HGNC:9068
    See related
    Ensembl:ENSG00000129219 HPRD:03857; MIM:602384; Vega:OTTHUMG00000090779
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
    Orthologs
    Location:
    17p13.1
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (4807101..4823432)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4710396..4726727)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene glycolipid transfer protein domain containing 2 Neighboring gene proteasome subunit beta 6 Neighboring gene misshapen like kinase 1 Neighboring gene ATPase H+ transporting V0 subunit c pseudogene 1 Neighboring gene chromosome 17 open reading frame 107 Neighboring gene cholinergic receptor nicotinic epsilon subunit

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-induced phosphatidylcholine-specific phospholipase D (PLD) activity is dependent on the activation of ERK1/2 PubMed

    Go to the HIV-1, Human Interaction Database

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    • Arf1 pathway, organism-specific biosystem (from Pathway Interaction Database)
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    • Arf6 trafficking events, organism-specific biosystem (from Pathway Interaction Database)
      Arf6 trafficking events, organism-specific biosystem
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    • Choline metabolism in cancer, organism-specific biosystem (from KEGG)
      Choline metabolism in cancer, organism-specific biosystemAbnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS...
    • Choline metabolism in cancer, conserved biosystem (from KEGG)
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    • Endocytosis, conserved biosystem (from KEGG)
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    • Ether lipid metabolism, organism-specific biosystem (from KEGG)
      Ether lipid metabolism, organism-specific biosystem
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      Ether lipid metabolism, conserved biosystem
      Ether lipid metabolism
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
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    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
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    • Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem (from Pathway Interaction Database)
      Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem
      Fc-epsilon receptor I signaling in mast cells
    • Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
      Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemPhagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phag...
    • Glutamatergic synapse, organism-specific biosystem (from KEGG)
      Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Glutamatergic synapse, conserved biosystem (from KEGG)
      Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Glycerophospholipid biosynthesis, organism-specific biosystem (from REACTOME)
      Glycerophospholipid biosynthesis, organism-specific biosystemGlycerophospholipids are important structural and functional components of biological membranes and constituents of serum lipoproteins and the pulmonary surfactant. In addition, glycerophospholipids...
    • Glycerophospholipid metabolism, organism-specific biosystem (from KEGG)
      Glycerophospholipid metabolism, organism-specific biosystem
      Glycerophospholipid metabolism
    • Glycerophospholipid metabolism, conserved biosystem (from KEGG)
      Glycerophospholipid metabolism, conserved biosystem
      Glycerophospholipid metabolism
    • GnRH signaling pathway, organism-specific biosystem (from KEGG)
      GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • GnRH signaling pathway, conserved biosystem (from KEGG)
      GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
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    • LPA receptor mediated events, organism-specific biosystem (from Pathway Interaction Database)
      LPA receptor mediated events, organism-specific biosystem
      LPA receptor mediated events
    • Metabolic pathways, organism-specific biosystem (from KEGG)
      Metabolic pathways, organism-specific biosystem
      Metabolic pathways
    • Metabolism, organism-specific biosystem (from REACTOME)
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    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
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    • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
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    • Phospholipid metabolism, organism-specific biosystem (from REACTOME)
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    • Ras signaling pathway, organism-specific biosystem (from KEGG)
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    • RhoA signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      RhoA signaling pathway, organism-specific biosystem
      RhoA signaling pathway
    • Role of phospholipids in phagocytosis, organism-specific biosystem (from REACTOME)
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    • Sphingolipid signaling pathway, organism-specific biosystem (from KEGG)
      Sphingolipid signaling pathway, organism-specific biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
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    • Synthesis of PA, organism-specific biosystem (from REACTOME)
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    • Synthesis of PG, organism-specific biosystem (from REACTOME)
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    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
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    • cAMP signaling pathway, conserved biosystem (from KEGG)
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    • mTOR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      mTOR signaling pathway, organism-specific biosystem
      mTOR signaling pathway
    • phospholipases, organism-specific biosystem (from BIOCYC)
      phospholipases, organism-specific biosystem
      phospholipases
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase D activity TAS
    Traceable Author Statement
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    inositol lipid-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidic acid biosynthetic process TAS
    Traceable Author Statement
    more info
     
    regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    synaptic vesicle recycling TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    phospholipase D2
    Names
    PLD1C
    choline phosphatase 2
    hPLD2
    phosphatidylcholine-hydrolyzing phospholipase D2
    NP_001230037.1
    NP_002654.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029608.1 RefSeqGene

      Range
      5001..21332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001243108.1NP_001230037.1  phospholipase D2 isoform PLD2B

      See identical proteins and their annotated locations for NP_001230037.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (PLD2B) has the same N- and C-termini but is shorter compared to isoform PLD2A.
      Source sequence(s)
      AF033850, AF038440, AF038441, BC015033, DA390950, DC407587
      Consensus CDS
      CCDS58507.1
      UniProtKB/Swiss-Prot
      O14939
      Related
      ENSP00000459571, OTTHUMP00000258108, ENST00000572940, OTTHUMT00000439787
      Conserved Domains (5) summary
      cd09845
      Location:614795
      PLDc_vPLD2_2; Catalytic domain, repeat 2, of vertebrate phospholipase D2
      PLN02866
      Location:66907
      PLN02866; phospholipase D
      cl02563
      Location:62192
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cd01254
      Location:180309
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain
      cl15239
      Location:335475
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
    2. NM_002663.4NP_002654.3  phospholipase D2 isoform PLD2A

      See identical proteins and their annotated locations for NP_002654.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (PLD2A).
      Source sequence(s)
      AF033850, AF038440, BC015033, DA390950, DC407587
      Consensus CDS
      CCDS11057.1
      UniProtKB/Swiss-Prot
      O14939
      Related
      ENSP00000263088, OTTHUMP00000115984, ENST00000263088, OTTHUMT00000207561
      Conserved Domains (5) summary
      cd09845
      Location:614795
      PLDc_vPLD2_2; Catalytic domain, repeat 2, of vertebrate phospholipase D2
      PLN02866
      Location:66918
      PLN02866; phospholipase D
      cl02563
      Location:62192
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cd01254
      Location:180309
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain
      cl15239
      Location:335475
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

      Range
      4807101..4823432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005256695.2XP_005256752.1  

      Conserved Domains (3) summary
      cl02563
      Location:62192
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cd01254
      Location:180309
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain
      cl15239
      Location:335475
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
    2. XM_011523941.1XP_011522243.1  

      Conserved Domains (3) summary
      cl02563
      Location:62192
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cd01254
      Location:180309
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain
      cl15239
      Location:335475
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
    3. XM_011523942.1XP_011522244.1  

      Conserved Domains (3) summary
      cl02563
      Location:62192
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cd01254
      Location:180309
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain
      cl15239
      Location:335475
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
    4. XM_005256696.2XP_005256753.1  

      Conserved Domains (2) summary
      cd09845
      Location:229410
      PLDc_vPLD2_2; Catalytic domain, repeat 2, of vertebrate phospholipase D2
      cl15239
      Location:190
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      4719366..4735679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)