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    PKM pyruvate kinase M1/2 [ Bos taurus (cattle) ]

    Gene ID: 512571, updated on 3-Apr-2024

    Summary

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    Official Symbol
    PKMprovided by VGNC
    Official Full Name
    pyruvate kinase M1/2provided by VGNC
    Primary source
    VGNC:VGNC:55132
    See related
    BGD:BT11448; Ensembl:ENSBTAG00000001601
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 10
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (19137913..19164576, complement)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene myosin IXA Neighboring gene collagen alpha-2(I) chain-like Neighboring gene SUMO peptidase family member, NEDD8 specific Neighboring gene GRAM domain containing 2A Neighboring gene uncharacterized LOC132346341 Neighboring gene poly(ADP-ribose) polymerase family member 6 Neighboring gene CUGBP Elav-like family member 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Secreted parasite Pin1 isomerase stabilizes host PKM2 to reprogram host cell metabolism. Marsolier J, et al. Commun Biol, 2019. PMID 31044177, Free PMC Article
    2. PKM2 knockdown influences SREBP activation and lipid synthesis in bovine mammary-gland epithelial MAC-T cells. Su BQ, et al. Biotechnol Lett, 2018 Apr. PMID 29383471
    3. Molecular characterization and expression of the equine M(1) and M(2)-pyruvate kinase gene. Echigoya Y, et al. Comp Biochem Physiol B Biochem Mol Biol, 2008 Sep. PMID 18602015
    4. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
    5. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Secreted parasite Pin1 isomerase stabilizes host PKM2 to reprogram host cell metabolism.
      Title: Secreted parasite Pin1 isomerase stabilizes host PKM2 to reprogram host cell metabolism.
    2. Although the knockdown of PKM2 had no effect on MAC-T cell growth, the reduced expression of PKM2 attenuated the mRNA and protein expression of key enzymes involved in sterol synthesis through the SREBP pathway.
      Title: PKM2 knockdown influences SREBP activation and lipid synthesis in bovine mammary-gland epithelial MAC-T cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables potassium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables pyruvate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyruvate kinase PKM
    Names
    pyruvate kinase 3
    pyruvate kinase, muscle
    NP_001192656.1
    XP_005211367.1
    XP_059746321.1
    XP_059746322.1
    XP_059746323.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205727.1 → NP_001192656.1  pyruvate kinase PKM

      See identical proteins and their annotated locations for NP_001192656.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000010
      UniProtKB/TrEMBL
      A5D984, F1MIZ0, Q3ZC87
      Related
      ENSBTAP00000044619.3, ENSBTAT00000047412.5
      Conserved Domains (1) summary
      cd00288
      Location:42 → 530
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      19137913..19164576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005211310.3 → XP_005211367.1  pyruvate kinase PKM isoform X3

      See identical proteins and their annotated locations for XP_005211367.1

      UniProtKB/TrEMBL
      Q3ZC87
      Related
      ENSBTAP00000075995.1, ENSBTAT00000108129.1
      Conserved Domains (1) summary
      cd00288
      Location:42 → 530
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

    2. XM_059890338.1 → XP_059746321.1  pyruvate kinase PKM isoform X1

    3. XM_059890339.1 → XP_059746322.1  pyruvate kinase PKM isoform X2

    4. XM_059890340.1 → XP_059746323.1  pyruvate kinase PKM isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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