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    IRX4 iroquois homeobox 4 [ Homo sapiens (human) ]

    Gene ID: 50805, updated on 5-Jul-2015
    Official Symbol
    IRX4provided by HGNC
    Official Full Name
    iroquois homeobox 4provided by HGNC
    Primary source
    HGNC:HGNC:6129
    See related
    Ensembl:ENSG00000113430; HPRD:09369; MIM:606199; Vega:OTTHUMG00000090411
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IRXA3
    Orthologs
    See IRX4 in Epigenomics, MapViewer
    Location:
    5p15.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (1877427..1887179, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (1877541..1887293, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L36 Neighboring gene NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) Neighboring gene uncharacterized LOC101929034 Neighboring gene uncharacterized LOC101929056 Neighboring gene uncharacterized LOC101929081 Neighboring gene uncharacterized LOC105374616

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study.
    NHGRI GWA Catalog
    • Cardiac Progenitor Differentiation, organism-specific biosystem (from WikiPathways)
      Cardiac Progenitor Differentiation, organism-specific biosystemFactors involved in the induction of cardiac differentiation in vitro and in vivo. This model was based on the below two review articles.
    • Heart Development, organism-specific biosystem (from WikiPathways)
      Heart Development, organism-specific biosystemThis pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impa...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC131996

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    establishment of organ orientation IEA
    Inferred from Electronic Annotation
    more info
     
    heart development IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    iroquois-class homeodomain protein IRX-4
    Names
    homeodomain protein IRXA3
    iroquois homeobox protein 4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278632.1NP_001265561.1  iroquois-class homeodomain protein IRX-4 isoform b

      See identical proteins and their annotated locations for NP_001265561.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and lacks an alternate internal exon compared to variant 4. It encodes isoform b which is shorter than isoform a.
      Source sequence(s)
      AB690778, AC025183, AI566193
      Consensus CDS
      CCDS3867.1
      UniProtKB/Swiss-Prot
      P78413
      Related
      ENSP00000424235, OTTHUMP00000220474, ENST00000513692, OTTHUMT00000365499
      Conserved Domains (1) summary
      cd00086
      Location:145204
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    2. NM_001278633.1NP_001265562.1  iroquois-class homeodomain protein IRX-4 isoform a

      See identical proteins and their annotated locations for NP_001265562.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 4. Both variants 2 and 4 encode the same protein.
      Source sequence(s)
      AB690779, AC025183, AI566193
      Consensus CDS
      CCDS75225.1
      UniProtKB/Swiss-Prot
      P78413
      Related
      ENSP00000481396, ENST00000622814
      Conserved Domains (1) summary
      cd00086
      Location:171230
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    3. NM_001278634.1NP_001265563.1  iroquois-class homeodomain protein IRX-4 isoform b

      See identical proteins and their annotated locations for NP_001265563.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal exon compared to variant 4. It encodes isoform b, which is shorter than isoform a.
      Source sequence(s)
      AB690780, AC025183, AI566193
      Consensus CDS
      CCDS3867.1
      UniProtKB/Swiss-Prot
      P78413
      Related
      ENSP00000423161, OTTHUMP00000220475, ENST00000505790, OTTHUMT00000365500
      Conserved Domains (1) summary
      cd00086
      Location:145204
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    4. NM_001278635.1NP_001265564.1  iroquois-class homeodomain protein IRX-4 isoform a

      See identical proteins and their annotated locations for NP_001265564.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript. Both variants 2 and 4 encode the same protein.
      Source sequence(s)
      AB690781, AC025183, AI566193
      Consensus CDS
      CCDS75225.1
      UniProtKB/Swiss-Prot
      P78413
      Related
      ENSP00000482393, ENST00000613726
      Conserved Domains (1) summary
      cd00086
      Location:171230
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    5. NM_016358.2NP_057442.1  iroquois-class homeodomain protein IRX-4 isoform b

      See identical proteins and their annotated locations for NP_057442.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate internal exon compared to variant 4. It encodes isoform b which is shorter than isoform a.
      Source sequence(s)
      AF124733, AI566193, BC110912, BC136505
      Consensus CDS
      CCDS3867.1
      UniProtKB/Swiss-Prot
      P78413
      Related
      ENSP00000231357, OTTHUMP00000115477, ENST00000231357, OTTHUMT00000206837
      Conserved Domains (1) summary
      cd00086
      Location:145204
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

      Range
      1877427..1887179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      1877411..1887153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)