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IRX4 iroquois homeobox 4 [ Homo sapiens (human) ]

Gene ID: 50805, updated on 26-Aug-2014
Official Symbol
IRX4provided by HGNC
Official Full Name
iroquois homeobox 4provided by HGNC
Primary source
HGNC:6129
See related
Ensembl:ENSG00000113430; HPRD:09369; MIM:606199; Vega:OTTHUMG00000090411
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRXA3
See IRX4 in Epigenomics, MapViewer
Location:
5p15.3
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 5 NC_000005.10 (1877427..1887179, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (1877541..1887293, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) Neighboring gene uncharacterized LOC101929034 Neighboring gene uncharacterized LOC101929056 Neighboring gene uncharacterized LOC101929081 Neighboring gene SH3 domain-containing protein C23A1.17-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study.
NHGRI GWA Catalog
  • Cardiac Progenitor Differentiation, organism-specific biosystem (from WikiPathways)
    Cardiac Progenitor Differentiation, organism-specific biosystemFactors involved in the induction of cardiac differentiation in vitro and in vivo. This model was based on the below two review articles.
  • Heart Development, organism-specific biosystem (from WikiPathways)
    Heart Development, organism-specific biosystemThis pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impa...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC131996

Gene Ontology Provided by GOA

Function Evidence Code Pubs
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
establishment of organ orientation IEA
Inferred from Electronic Annotation
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
iroquois-class homeodomain protein IRX-4
Names
iroquois-class homeodomain protein IRX-4
homeodomain protein IRXA3
iroquois homeobox protein 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278632.1NP_001265561.1  iroquois-class homeodomain protein IRX-4 isoform b

    See proteins identical to NP_001265561.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and lacks an alternate internal exon compared to variant 4. It encodes isoform b which is shorter than isoform a.
    Source sequence(s)
    AB690778, AC025183, AI566193
    Consensus CDS
    CCDS3867.1
    UniProtKB/Swiss-Prot
    P78413
    Related
    ENSP00000424235, OTTHUMP00000220474, ENST00000513692, OTTHUMT00000365499
    Conserved Domains (1) summary
    cd00086
    Location:145204
    Blast Score: 159
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  2. NM_001278633.1NP_001265562.1  iroquois-class homeodomain protein IRX-4 isoform a

    See proteins identical to NP_001265562.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 4. Both variants 2 and 4 encode the same protein.
    Source sequence(s)
    AB690779, AC025183, AI566193
    Consensus CDS
    CCDS75225.1
    UniProtKB/Swiss-Prot
    P78413
    Related
    ENSP00000481396, ENST00000622814
    Conserved Domains (1) summary
    cd00086
    Location:171230
    Blast Score: 159
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  3. NM_001278634.1NP_001265563.1  iroquois-class homeodomain protein IRX-4 isoform b

    See proteins identical to NP_001265563.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon compared to variant 4. It encodes isoform b, which is shorter than isoform a.
    Source sequence(s)
    AB690780, AC025183, AI566193
    Consensus CDS
    CCDS3867.1
    UniProtKB/Swiss-Prot
    P78413
    Related
    ENSP00000423161, OTTHUMP00000220475, ENST00000505790, OTTHUMT00000365500
    Conserved Domains (1) summary
    cd00086
    Location:145204
    Blast Score: 159
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  4. NM_001278635.1NP_001265564.1  iroquois-class homeodomain protein IRX-4 isoform a

    See proteins identical to NP_001265564.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript. Both variants 2 and 4 encode the same protein.
    Source sequence(s)
    AB690781, AC025183, AI566193
    Consensus CDS
    CCDS75225.1
    UniProtKB/Swiss-Prot
    P78413
    Related
    ENSP00000482393, ENST00000613726
    Conserved Domains (1) summary
    cd00086
    Location:171230
    Blast Score: 159
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  5. NM_016358.2NP_057442.1  iroquois-class homeodomain protein IRX-4 isoform b

    See proteins identical to NP_057442.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate internal exon compared to variant 4. It encodes isoform b which is shorter than isoform a.
    Source sequence(s)
    AF124733, AI566193, BC110912, BC136505
    Consensus CDS
    CCDS3867.1
    UniProtKB/Swiss-Prot
    P78413
    Related
    ENSP00000231357, OTTHUMP00000115477, ENST00000231357, OTTHUMT00000206837
    Conserved Domains (1) summary
    cd00086
    Location:145204
    Blast Score: 159
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000005.10 

    Range
    1877427..1887179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714476.1XP_006714539.1  

    See proteins identical to XP_006714539.1

    UniProtKB/Swiss-Prot
    P78413
    Conserved Domains (1) summary
    cd00086
    Location:171230
    Blast Score: 159
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

Alternate HuRef

Genomic

  1. AC_000137.1 

    Range
    1859971..1869709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 

    Range
    1877411..1887153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)