PIK3C3 phosphatidylinositol 3-kinase catalytic subunit type 3 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: PIK3C3provided by VGNC
Official Full Name: phosphatidylinositol 3-kinase catalytic subunit type 3provided by VGNC
Primary source: VGNC:VGNC:91439
See related: Ensembl:ENSSSCG00000003749
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Ubiquitous expression in spleen (RPKM 5.1), lung (RPKM 4.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	6	NC_010448.4 (125890598..126038753)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	6	NC_010448.3 (117947967..118097705)

Chromosome 6 - NC_010448.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
Title: Evaluation of effects of multiple candidate genes (LEP, LEPR, MC4R, PIK3C3, and VRTN) on production traits in Duroc pigs.
confirmed that the polymorphism in PIK3C3 (C2604T) has the potential to be a genetic marker for production traits in Duroc pigs
Title: Association of an SNP marker in exon 24 of a class 3 phosphoinositide-3-kinase (PIK3C3) gene with production traits in Duroc pigs.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in autophagy of peroxisome	IEA Inferred from Electronic Annotation more info	PubMed
involved_in endocytosis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol-mediated signaling	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info	PubMed
located_in phagophore assembly site	IEA Inferred from Electronic Annotation more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class III, type I	IEA Inferred from Electronic Annotation more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class III, type II	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol 3-kinase catalytic subunit type 3

Names: PI3-kinase type 3; PI3K type 3; class 3 phosphoinositide-3-kinase; phosphoinositide-3-kinase, class 3; ptdIns-3-kinase type 3

NP_001012974.1

EC 2.7.1.137

XP_020949257.1

EC 2.7.1.137

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012956.2 → NP_001012974.1 phosphatidylinositol 3-kinase catalytic subunit type 3

See identical proteins and their annotated locations for NP_001012974.1

Status: PROVISIONAL

Source sequence(s)

AY823302

UniProtKB/Swiss-Prot

Q5D891

UniProtKB/TrEMBL

A0A480Q3N9, A0A4X1V2J3

Related

ENSSSCP00000059445.2, ENSSSCT00000060093.3

Conserved Domains (3) summary

cd08397
Location:26 → 186

C2_PI3K_class_III; C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)

cd00870
Location:283 → 502

PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...

cd00896
Location:539 → 883

PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010448.4 Reference Sscrofa11.1 Primary Assembly

Range

125890598..126038753

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021093598.1 → XP_020949257.1 phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1

UniProtKB/TrEMBL

A0A8D1JSZ5

Conserved Domains (3) summary

cd08397
Location:26 → 186

C2_PI3K_class_III; C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)

cd00870
Location:283 → 503

PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...

cd00896
Location:539 → 842

PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase