cdh5 cadherin 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cdh5provided by ZNC
Official Full Name: cadherin 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-040816-1
See related: Ensembl:ENSDARG00000075549 AllianceGenome:ZFIN:ZDB-GENE-040816-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mlb; fc88a07; wu:fc88a07
Summary: Predicted to enable cadherin binding activity and calcium ion binding activity. Acts upstream of or within with a positive effect on cell-cell junction organization. Acts upstream of or within circulatory system development; negative regulation of angiogenesis; and unidimensional cell growth. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction and bicellular tight junction. Is expressed in several structures, including angioblastic mesenchymal cell; cardiovascular system; intermediate cell mass of mesoderm; mesoderm; and nervous system. Orthologous to human CDH5 (cadherin 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 7

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (44445595..44467882)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (44106370..44128657)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wnt/beta-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling in the process of neovascularization of the central nervous system and blood-brain barrier formation.
Title: Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling.
zebrafish Cdh5 negatively regulates mobilization of aorta-gonad-mesonephros-derived hematopoietic stem cells
Title: Zebrafish Cdh5 negatively regulates mobilization of aorta-gonad-mesonephros-derived hematopoietic stem cells.
reveal biologically relevant changes in VE-cadherin tension that occur as the dorsal aorta matures and upon genetic and chemical perturbations during embryonic development
Title: Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafish.
VE-cadherin and Esama have distinct and redundant functions during blood vessel morphogenesis
Title: Distinct and redundant functions of Esama and VE-cadherin during vascular morphogenesis.
C1qr and c1qrl regulate angiogenesis through controlling endothelial cdh5 expression.
Title: C1qr and C1qrl redundantly regulate angiogenesis in zebrafish through controlling endothelial Cdh5.
the conserved targeting of VE-cadherin by miR-22 regulates endothelial inflammation, tissue injury, and angiogenesis.
Title: MicroRNA-22 regulates inflammation and angiogenesis via targeting VE-cadherin.
VE-cadherin/amotL2 complex is responsible for transmitting mechanical force between endothelial cells for the coordination of cellular morphogenesis consistent with aortic lumen expansion and function.
Title: AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion.
Cdh5 organizes junctional and cortical actin cytoskeletons and F-actin polymerization during endothelial cell elongation.
Title: Cdh5/VE-cadherin promotes endothelial cell interface elongation via cortical actin polymerization during angiogenic sprouting.
Regulatory pathways affecting vascular stabilization via VE-cadherin dynamics
Title: Regulatory pathways affecting vascular stabilization via VE-cadherin dynamics: insights from zebrafish (Danio rerio).
suggest that Ve-cadherin and Moesin1 function to establish and maintain apical/basal polarity during multicellular lumen formation in the intersegmental vessels
Title: Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within angiogenic sprout fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel endothelial cell delamination involved in blood vessel lumen ensheathment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel lumenization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell adhesion involved in sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion mediated by cadherin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within_positive_effect cell-cell junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellum vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endothelial tube lumen extension involved in blood vessel lumen ensheathment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of vasculature development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within unidimensional cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculature development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: cadherin-5

Names: VE-cadherin (vascular epithelium); cadherin 5, type 2, VE-cadherin (vascular epithelium); type 2; vascular endothelial cadherin; vecdn

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003983.1 → NP_001003983.1 cadherin-5 precursor

See identical proteins and their annotated locations for NP_001003983.1

Status: PROVISIONAL

Source sequence(s)

AY496430

UniProtKB/TrEMBL

Q68SP4

Related

ENSDARP00000104309.1, ENSDART00000108766.3

Conserved Domains (3) summary

cd11304
Location:160 → 257

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:86 → 153

CA; Cadherin repeats

pfam01049
Location:619 → 757

Cadherin_C; Cadherin cytoplasmic region