DUOX2 dual oxidase 2 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: DUOX2provided by VGNC
Official Full Name: dual oxidase 2provided by VGNC
Primary source: VGNC:VGNC:40121
See related: Ensembl:ENSCAFG00845029770
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: THOX2
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 30

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	30	NC_051834.1 (11658603..11679500, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	30	NC_006612.4 (11578140..11598867, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	30	NC_049251.1 (11806853..11827575, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	30	NC_049290.1 (11564842..11585734, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	30	NC_049771.1 (11687574..11708297, complement)

Chromosome 30 - NC_051834.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

DUOX2 (e-PCR)
- UniSTS:263013

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed
enables peroxidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables superoxide-generating NAD(P)H oxidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info	PubMed
involved_in superoxide anion generation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of NADPH oxidase complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: dual oxidase 2; LOW QUALITY PROTEIN: dual oxidase 2

Names: NADPH thyroid oxidase 2

XP_038298127.1

EC 1.6.3.1

XP_038317115.1

EC 1.6.3.1

XP_038317116.1

EC 1.6.3.1

XP_038372592.1

EC 1.6.3.1

XP_038372593.1

EC 1.6.3.1

XP_038436224.1

EC 1.6.3.1

XP_038436225.1

EC 1.6.3.1

XP_038500508.1

EC 1.6.3.1

XP_038500509.1

EC 1.6.3.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051834.1 Reference ROS_Cfam_1.0

Range

11658603..11679500 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038442199.1 → XP_038298127.1 LOW QUALITY PROTEIN: dual oxidase 2 isoform X1

UniProtKB/TrEMBL

A0A8C0TGI0, A0A8C0TMB2

Related

ENSCAFP00845042653.1, ENSCAFT00845054288.1

Conserved Domains (5) summary

cd06186
Location:1314 → 1588

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:85 → 641

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

PLN02292
Location:1161 → 1444

PLN02292; ferric-chelate reductase

COG5126
Location:800 → 905

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:871 → 932

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049290.1 Alternate UMICH_Zoey_3.1

Range

11564842..11585734 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038516664.1 → XP_038372592.1 dual oxidase 2 isoform X1

Conserved Domains (5) summary

cd06186
Location:1314 → 1588

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:85 → 641

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

PLN02292
Location:1161 → 1444

PLN02292; ferric-chelate reductase

COG5126
Location:800 → 905

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:871 → 932

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_038516665.1 → XP_038372593.1 dual oxidase 2 isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049771.1 Alternate UNSW_CanFamBas_1.0

Range

11687574..11708297 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038644580.1 → XP_038500508.1 dual oxidase 2 isoform X3

Conserved Domains (5) summary

cd06186
Location:1314 → 1588

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:85 → 641

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

PLN02292
Location:1161 → 1444

PLN02292; ferric-chelate reductase

COG5126
Location:800 → 905

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:871 → 932

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_038644581.1 → XP_038500509.1 dual oxidase 2 isoform X4

Conserved Domains (5) summary

cd06186
Location:1267 → 1541

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:38 → 594

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

PLN02292
Location:1114 → 1397

PLN02292; ferric-chelate reductase

COG5126
Location:753 → 858

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:824 → 885

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049251.1 Alternate UU_Cfam_GSD_1.0

Range

11806853..11827575 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038580296.1 → XP_038436224.1 dual oxidase 2 isoform X5

UniProtKB/TrEMBL

A0A8C0TGI0
XM_038580297.1 → XP_038436225.1 dual oxidase 2 isoform X6

UniProtKB/TrEMBL

A0A8I3QSW1

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006612.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

11578140..11598867 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038461187.1 → XP_038317115.1 dual oxidase 2 isoform X7

UniProtKB/TrEMBL

A0A8C0N5L4, A0A8C0TGI0, A0A8P0NFF3

Conserved Domains (5) summary

cd06186
Location:1314 → 1588

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:85 → 641

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

PLN02292
Location:1161 → 1444

PLN02292; ferric-chelate reductase

COG5126
Location:800 → 905

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:871 → 932

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_038461188.1 → XP_038317116.1 dual oxidase 2 isoform X8

UniProtKB/TrEMBL

A0A8I3QSW1

Conserved Domains (5) summary

cd06186
Location:1267 → 1541

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:38 → 594

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

PLN02292
Location:1114 → 1397

PLN02292; ferric-chelate reductase

COG5126
Location:753 → 858

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:824 → 885

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...