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    RSAD2 radical S-adenosyl methionine domain containing 2 [ Sus scrofa (pig) ]

    Gene ID: 396752, updated on 5-Mar-2024

    Summary

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    Official Symbol
    RSAD2provided by VGNC
    Official Full Name
    radical S-adenosyl methionine domain containing 2provided by VGNC
    Primary source
    VGNC:VGNC:92472
    See related
    Ensembl:ENSSSCG00000008648
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    CIG6; IRG6; SAND
    Expression
    Ubiquitous expression in lung (RPKM 88.9), heart (RPKM 48.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 3 NC_010445.4 (128880853..128897809, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 3 NC_010445.3 (137666404..137683529, complement)

    Chromosome 3 - NC_010445.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102161862 Neighboring gene ring finger protein 144A Neighboring gene cytidine/uridine monophosphate kinase 2 Neighboring gene uncharacterized LOC100624063

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. The antiviral protein viperin interacts with the viral N protein to inhibit proliferation of porcine epidemic diarrhea virus. Wu J, et al. Arch Virol, 2020 Oct. PMID 32719955, Free PMC Article
    2. Viperin inhibits classical swine fever virus replication by interacting with viral nonstructural 5A protein. Xu C, et al. J Med Virol, 2020 Feb. PMID 31517388
    3. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
    4. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The selected genes NR6A1, RSAD2-CMPK2, and COL3A1 contribute to body size variation in Meishan pigs through different patterns.
      Title: The selected genes NR6A1, RSAD2-CMPK2, and COL3A1 contribute to body size variation in Meishan pigs through different patterns.
    2. Viperin inhibits classical swine fever virus replication by interacting with viral nonstructural 5A protein.
      Title: Viperin inhibits classical swine fever virus replication by interacting with viral nonstructural 5A protein.
    3. The antiviral protein viperin interacts with the viral N protein to inhibit proliferation of porcine epidemic diarrhea virus.
      Title: The antiviral protein viperin interacts with the viral N protein to inhibit proliferation of porcine epidemic diarrhea virus.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    S-adenosylmethionine-dependent nucleotide dehydratase RSAD2
    Names
    inflammatory response gene 6 protein
    inflammatory response protein 6
    radical S-adenosyl methionine domain-containing protein 2
    viperin
    virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213817.1 → NP_998982.1  S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

      See identical proteins and their annotated locations for NP_998982.1

      Status: PROVISIONAL

      Source sequence(s)
      AF156929
      UniProtKB/Swiss-Prot
      Q9MZU4
      UniProtKB/TrEMBL
      A0A287B6T9, A0A4X1UE22
      Related
      ENSSSCP00000052007.2, ENSSSCT00000050256.2
      Conserved Domains (2) summary
      cd01335
      Location:79 → 256
      Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
      TIGR04278
      Location:13 → 362
      viperin; antiviral radical SAM protein viperin

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010445.4 Reference Sscrofa11.1 Primary Assembly

      Range
      128880853..128897809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9MZU4.1 GenPept UniProtKB/Swiss-Prot:Q9MZU4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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