Display Settings:

Format

Send to:

Choose Destination
  • Filters activated: Current only. Clear all to show 1 items.

LAG3 lymphocyte-activation gene 3 [ Homo sapiens (human) ]

Gene ID: 3902, updated on 21-Mar-2015
Official Symbol
LAG3provided by HGNC
Official Full Name
lymphocyte-activation gene 3provided by HGNC
Primary source
HGNC:HGNC:6476
See related
Ensembl:ENSG00000089692; HPRD:01077; MIM:153337; Vega:OTTHUMG00000169197
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD223
Summary
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Orthologs
See LAG3 in MapViewer
Location:
12p13.32
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (6772483..6778455)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6881670..6887621)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene myeloid leukemia factor 2 Neighboring gene parathymosin Neighboring gene CD4 molecule Neighboring gene G protein-coupled receptor 162

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MHC class II protein binding IDA
Inferred from Direct Assay
more info
PubMed 
antigen binding TAS
Traceable Author Statement
more info
PubMed 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-2 biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of natural killer cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
lymphocyte activation gene 3 protein
Names
lymphocyte activation gene 3 protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002286.5NP_002277.4  lymphocyte activation gene 3 protein precursor

    See identical proteins and their annotated locations for NP_002277.4

    Status: REVIEWED

    Source sequence(s)
    AA687676, AC125494, AI274900, X51985
    Consensus CDS
    CCDS8561.1
    UniProtKB/Swiss-Prot
    P18627
    Related
    ENSP00000203629, OTTHUMP00000240397, ENST00000203629, OTTHUMT00000402846
    Conserved Domains (2) summary
    cd00096
    Location:185248
    Ig; Immunoglobulin domain
    smart00410
    Location:267348
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    6772483..6778455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520956.1XP_011519258.1  

    Conserved Domains (2) summary
    cd00096
    Location:185248
    Ig; Immunoglobulin domain
    smart00410
    Location:267348
    IG_like; Immunoglobulin like

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    6880658..6886609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)