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    LAG3 lymphocyte-activation gene 3 [ Homo sapiens (human) ]

    Gene ID: 3902, updated on 26-Jul-2015
    Official Symbol
    LAG3provided by HGNC
    Official Full Name
    lymphocyte-activation gene 3provided by HGNC
    Primary source
    HGNC:HGNC:6476
    See related
    Ensembl:ENSG00000089692; HPRD:01077; MIM:153337; Vega:OTTHUMG00000169197
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD223
    Summary
    Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
    Orthologs
    See LAG3 in Epigenomics, MapViewer
    Location:
    12p13.32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (6772483..6778455)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6881670..6887621)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene myeloid leukemia factor 2 Neighboring gene parathymosin Neighboring gene CD4 molecule Neighboring gene G protein-coupled receptor 162

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    MHC class II protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    antigen binding TAS
    Traceable Author Statement
    more info
    PubMed 
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of T cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-2 biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of natural killer cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    lymphocyte activation gene 3 protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002286.5NP_002277.4  lymphocyte activation gene 3 protein precursor

      See identical proteins and their annotated locations for NP_002277.4

      Status: REVIEWED

      Source sequence(s)
      AA687676, AC125494, AI274900, X51985
      Consensus CDS
      CCDS8561.1
      UniProtKB/Swiss-Prot
      P18627
      Related
      ENSP00000203629, OTTHUMP00000240397, ENST00000203629, OTTHUMT00000402846
      Conserved Domains (2) summary
      cd00096
      Location:185248
      Ig; Immunoglobulin domain
      smart00410
      Location:267348
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

      Range
      6772483..6778455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520956.1XP_011519258.1  

      Conserved Domains (2) summary
      cd00096
      Location:185248
      Ig; Immunoglobulin domain
      smart00410
      Location:267348
      IG_like; Immunoglobulin like

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      6880658..6886609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)