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    N4bp2l2 NEDD4 binding protein 2-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 381695, updated on 8-Feb-2024

    Summary

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    Official Symbol
    N4bp2l2provided by MGI
    Official Full Name
    NEDD4 binding protein 2-like 2provided by MGI
    Primary source
    MGI:MGI:2687207
    See related
    Ensembl:ENSMUSG00000029655 AllianceGenome:MGI:2687207
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    zag1; Gm38758; 2700092H06Rik
    Summary
    Enables transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within blastocyst development. Located in nucleus. Orthologous to human N4BP2L2 (NEDD4 binding protein 2 like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.7), CNS E18 (RPKM 3.4) and 25 other tissues See more
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    Genomic context

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    Location:
    5; 5 G3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (150515310..150589213, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (150599931..150665748, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene breast cancer 2, early onset Neighboring gene predicted gene, 23641 Neighboring gene predicted gene 42529 Neighboring gene NEDD4 binding protein 2-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E3639 Neighboring gene STARR-positive B cell enhancer mm9_chr5:151397981-151398282 Neighboring gene STARR-seq mESC enhancer starr_14956 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:151414417-151414570 Neighboring gene STARR-positive B cell enhancer ABC_E10368 Neighboring gene STARR-positive B cell enhancer ABC_E2774 Neighboring gene STARR-positive B cell enhancer ABC_E6410 Neighboring gene STARR-positive B cell enhancer ABC_E6411 Neighboring gene STARR-positive B cell enhancer ABC_E3640 Neighboring gene predicted gene, 40353 Neighboring gene STARR-seq mESC enhancer starr_14958 Neighboring gene PDS5 cohesin associated factor B Neighboring gene STARR-positive B cell enhancer ABC_E4810 Neighboring gene predicted gene, 24630

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zag expression during aging suppresses proliferation after kidney injury. Schmitt R, et al. J Am Soc Nephrol, 2008 Dec. PMID 18815245, Free PMC Article
    2. Identification of ZAG1, a novel protein expressed in mouse preimplantation, and its putative roles in zygotic genome activation. Matsuoka T, et al. J Reprod Dev, 2008 Jun. PMID 18360097
    3. Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase. Salipante SJ, et al. Mol Cell Biol, 2009 Aug. PMID 19506020, Free PMC Article
    4. ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB. Won M, et al. Cell Death Differ, 2022 Jun. PMID 34839354, Free PMC Article
    5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. increased Zag expression in the aged kidney acts to suppress the proliferative response to injury
      Title: Zag expression during aging suppresses proliferation after kidney injury.
    2. results suggest that ZAG1 may be closely associated with zygotic gene expression in mouse preimplantation embryos
      Title: Identification of ZAG1, a novel protein expressed in mouse preimplantation, and its putative roles in zygotic genome activation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC25830

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hematopoietic stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of hematopoietic stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NEDD4-binding protein 2-like 2
    Names
    phosphonoformate immuno-associated protein 5 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362416.1 → NP_001349345.1  NEDD4-binding protein 2-like 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158558, AK038740, BC062895
      Conserved Domains (1) summary
      pfam13671
      Location:396 → 529
      AAA_33; AAA domain

    2. NM_201369.3 → NP_958757.2  NEDD4-binding protein 2-like 2 isoform 2

      See identical proteins and their annotated locations for NP_958757.2

      Status: VALIDATED

      Source sequence(s)
      AC158558, AK038740, AW488478, CA556104, CB231597, CD561511, CF724618, CJ162163
      Consensus CDS
      CCDS19888.2
      UniProtKB/Swiss-Prot
      Q8JZS6
      Related
      ENSMUSP00000113895.2, ENSMUST00000118316.8
      Conserved Domains (2) summary
      pfam13671
      Location:396 → 529
      AAA_33; AAA domain
      cl17190
      Location:396 → 526
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      150515310..150589213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254630.2 → XP_030110490.1  NEDD4-binding protein 2-like 2 isoform X1

      Conserved Domains (1) summary
      pfam13671
      Location:396 → 529
      AAA_33; AAA domain

    2. XM_030254629.2 → XP_030110489.1  NEDD4-binding protein 2-like 2 isoform X1

      Conserved Domains (1) summary
      pfam13671
      Location:396 → 529
      AAA_33; AAA domain

    3. XM_036165248.1 → XP_036021141.1  NEDD4-binding protein 2-like 2 isoform X1

      Conserved Domains (1) summary
      pfam13671
      Location:396 → 529
      AAA_33; AAA domain

    4. XM_036165249.1 → XP_036021142.1  NEDD4-binding protein 2-like 2 isoform X1

      Conserved Domains (1) summary
      pfam13671
      Location:396 → 529
      AAA_33; AAA domain

    5. XM_036165251.1 → XP_036021144.1  NEDD4-binding protein 2-like 2 isoform X1

      Conserved Domains (1) summary
      pfam13671
      Location:396 → 529
      AAA_33; AAA domain

    6. XM_036165252.1 → XP_036021145.1  NEDD4-binding protein 2-like 2 isoform X2

      Conserved Domains (1) summary
      pfam13671
      Location:17 → 93
      AAA_33; AAA domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8JZS6.2 GenPept UniProtKB/Swiss-Prot:Q8JZS6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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