Gabpb1l GA binding protein transcription factor, beta subunit 1-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gabpb1lprovided by RGD
Official Full Name: GA binding protein transcription factor, beta subunit 1-likeprovided by RGD
Primary source: RGD:1310235
See related: AllianceGenome:RGD:1310235
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nrf2b; Gabpb1; Gabpb2; Nrf-2beta
Summary: Predicted to enable transcription cis-regulatory region binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 147.6), Lung (RPKM 106.2) and 9 other tissues See more
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Genomic context

Location:: 17q12.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (55052423..55054254)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (50356830..50358810)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (52938849..52941213)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NRF-2alpha and NRF-2beta respond to increased neuronal activity by translocating from the cytoplasm to the nucleus, where they engage in transcriptional activation of target genes.
Title: Ultrastructural study of depolarization-induced translocation of NRF-2 transcription factor in cultured rat visual cortical neurons.
GA-binding protein (GABPalpha/GABPbeta)is critical and functionally relevant Ets factor that regulates prolactin promoter activity via the basal transcription element site.
Title: Purification and mass spectrometric identification of GA-binding protein (GABP) as the functional pituitary Ets factor binding to the basal transcription element of the prolactin promoter.

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General gene information

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Markers

Gabpb1 (e-PCR), detects polymorphism
- UniSTS:516135

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GA-binding protein subunit beta-1

Names: GA binding protein transcription factor, beta subunit 2, 47kDa; GA repeat binding protein, beta 1; nuclear respiratory factor 2 beta

NP_001128487.1

EC 3.2.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135015.1 → NP_001128487.1 GA-binding protein subunit beta-1

See identical proteins and their annotated locations for NP_001128487.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000017

Conserved Domains (5) summary

cd00204
Location:34 → 156

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:42 → 133

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:10 → 58

Ank_4; Ankyrin repeats (many copies)

pfam16566
Location:329 → 378

CREPT; Cell-cycle alteration and expression-elevated protein in tumour

sd00045
Location:38 → 68

ANK; ANK repeat [structural motif]