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    Rnaseh2b ribonuclease H2, subunit B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361056, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rnaseh2bprovided by RGD
    Official Full Name
    ribonuclease H2, subunit Bprovided by RGD
    Primary source
    RGD:1359710
    See related
    Ensembl:ENSRNOG00000009192 AllianceGenome:RGD:1359710
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in RNA catabolic process and ribonucleotide metabolic process. Predicted to act upstream of or within several processes, including in utero embryonic development; positive regulation of fibroblast proliferation; and regulation of cell cycle phase transition. Predicted to be part of ribonuclease H2 complex. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2B (ribonuclease H2 subunit B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 271.9), Spleen (RPKM 78.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    15p12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (40717252..40770826)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (36541200..36592016)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (45422010..45472792)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547888 Neighboring gene deleted in lymphocytic leukemia, 7 Neighboring gene uncharacterized LOC120097007 Neighboring gene guanylate cyclase 1 soluble subunit beta 2 Neighboring gene similar to human chromosome 13 open reading frame 42

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutières syndrome defects. Figiel M, et al. J Biol Chem, 2011 Mar 25. PMID 21177858, Free PMC Article
    2. The structure of the mammalian RNase H2 complex provides insight into RNA.NA hybrid processing to prevent immune dysfunction. Shaban NM, et al. J Biol Chem, 2010 Feb 5. PMID 19923215, Free PMC Article
    3. Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity. Hiller B, et al. J Exp Med, 2012 Jul 30. PMID 22802351, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94780

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in RNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA damage checkpoint IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribonucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ribonucleotide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonuclease H2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonuclease H2 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonuclease H2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonuclease H2 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ribonuclease H2 subunit B
    Names
    RNase H2 subunit B
    ribonuclease HI subunit B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007007.1 → NP_001007008.1  ribonuclease H2 subunit B

      See identical proteins and their annotated locations for NP_001007008.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083791
      UniProtKB/Swiss-Prot
      Q5XI96
      UniProtKB/TrEMBL
      A0A8L2Q5D7, A6K6C8
      Related
      ENSRNOP00000012231.5, ENSRNOT00000012231.5
      Conserved Domains (1) summary
      cd09270
      Location:16 → 298
      RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      40717252..40770826
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274421.1 → XP_063130491.1  ribonuclease H2 subunit B isoform X12

    2. XM_039093506.2 → XP_038949434.1  ribonuclease H2 subunit B isoform X4

      UniProtKB/TrEMBL
      A0A8L2Q5D7
      Conserved Domains (1) summary
      cd09270
      Location:16 → 274
      RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids

    3. XM_063274419.1 → XP_063130489.1  ribonuclease H2 subunit B isoform X9

    4. XM_063274420.1 → XP_063130490.1  ribonuclease H2 subunit B isoform X11

    5. XM_063274417.1 → XP_063130487.1  ribonuclease H2 subunit B isoform X7

    6. XM_063274416.1 → XP_063130486.1  ribonuclease H2 subunit B isoform X3

    7. XM_039093508.2 → XP_038949436.1  ribonuclease H2 subunit B isoform X10

      UniProtKB/TrEMBL
      A6K6C9
      Conserved Domains (1) summary
      cd09270
      Location:30 → 171
      RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids

    8. XM_039093505.2 → XP_038949433.1  ribonuclease H2 subunit B isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q5D7
      Conserved Domains (1) summary
      cd09270
      Location:30 → 298
      RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids

    9. XM_008770764.4 → XP_008768986.1  ribonuclease H2 subunit B isoform X6

      UniProtKB/TrEMBL
      A0A8L2Q5D7
      Conserved Domains (1) summary
      cd09270
      Location:30 → 272
      RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids

    10. XM_039093507.2 → XP_038949435.1  ribonuclease H2 subunit B isoform X5

      UniProtKB/TrEMBL
      A0A8L2Q5D7
      Conserved Domains (1) summary
      cd09270
      Location:30 → 171
      RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids

    11. XM_008770765.4 → XP_008768987.1  ribonuclease H2 subunit B isoform X8

      UniProtKB/TrEMBL
      A6K6C9
      Conserved Domains (1) summary
      cd09270
      Location:30 → 171
      RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids

    12. XM_008770762.4 → XP_008768984.1  ribonuclease H2 subunit B isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q5D7
      Conserved Domains (1) summary
      cd09270
      Location:30 → 299
      RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids

    13. XM_039093509.1 → XP_038949437.1  ribonuclease H2 subunit B isoform X13

      Conserved Domains (1) summary
      cd09270
      Location:1 → 209
      RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI96.1 GenPept UniProtKB/Swiss-Prot:Q5XI96

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