Akap10 A-kinase anchoring protein 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Akap10provided by RGD
Official Full Name: A-kinase anchoring protein 10provided by RGD
Primary source: RGD:1308869
See related: Ensembl:ENSRNOG00000002899 AllianceGenome:RGD:1308869
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: D-akap2
Summary: Predicted to enable protein kinase A binding activity. Predicted to be involved in protein localization. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrion and plasma membrane. Orthologous to human AKAP10 (A-kinase anchoring protein 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 78.2), Spleen (RPKM 74.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (47044819..47108153, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (46545371..46608730, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (48150902..48210074, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The crystal structure of the helical motif from D-AKAP2 (Akap10), a dual-specific AKAP, bound to the RIIalpha D/D domain from Prkar2a, was analysed.
Title: A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase.

Submit: New GeneRIF Correction

General gene information

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Markers

AF021833 (e-PCR)
- UniSTS:185885

AA893014 (e-PCR)
- UniSTS:249992

AA893014 (e-PCR)
- UniSTS:261295

RH140963 (e-PCR)
- UniSTS:222964

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein kinase A binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: A-kinase anchor protein 10, mitochondrial

Names: A kinase (PRKA) anchor protein 10; Dual specific A kinase anchoring protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114606.2 → NP_001108078.1 A-kinase anchor protein 10, mitochondrial

Status: VALIDATED

Source sequence(s)

CK475954, JAXUCZ010000010

UniProtKB/TrEMBL

F1LNB3

Related

ENSRNOP00000003871.5, ENSRNOT00000003871.5

Conserved Domains (3) summary

cd08721
Location:383 → 503

RGS_AKAP2_2; Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2

cd08735
Location:122 → 367

RGS_AKAP2_1; Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2

cd12804
Location:618 → 662

AKAP10_AKB; PKA-binding (AKB) domain of A Kinase Anchor Protein 10