Cyt-c-p Cytochrome c proximal [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cyt-c-pprovided by FlyBase
Official Full Name: Cytochrome c proximalprovided by FlyBase
Primary source: FLYBASE:FBgn0284248
Locus tag: Dmel_CG17903
See related: AllianceGenome:FB:FBgn0284248
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17903; CYC; CYC2; Cyct-c-p; cyt c; Cyt c; Cyt C; cyt c-p; Cyt-c; cyt-c-p; Cyt-c-P; cyt-c2; Cyt-c2; cyt.c; Cytc; CytC; CytC-2; cytC-p; Cytc-p; cytochrome c; dc4; DC4; dCyt.C-p; DMc01; Dmel\CG17903; l(2)k13905; P84029; pDMc01
Summary: Enables electron transfer activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen; mitochondrial electron transport, ubiquinol to cytochrome c; and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. Located in cytosol and mitochondrion. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic Malpighian tubule; embryonic/larval nervous system; extended germ band embryo; and gut section. Human ortholog(s) of this gene implicated in cholangiocarcinoma; lung non-small cell carcinoma; pancreatic cancer; and thrombocytopenia. Orthologous to human CYCS (cytochrome c, somatic). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 36A11-36A12; 2-52 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (16719932..16722644)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (16719932..16722644)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CHCHD2 dynamically regulates the functions of cytochrome c in both oxidative phosphorylation and cell death in response to mitochondrial stress.
Title: Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c.
results reveal Blanks to be a unique component of a nuclear siRNA/dsRNA-binding complex that contributes to essential RNA silencing-related pathways in the male germ line
Title: Blanks, a nuclear siRNA/dsRNA-binding complex component, is required for Drosophila spermiogenesis.
DARK-mediated DRONC activation occurs independently of Cyt-c-p
Title: The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables electron transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables electron transfer activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	IBA Inferred from Biological aspect of Ancestor more info
involved_in oxidative phosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial intermembrane space	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed