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    WDR86 WD repeat domain 86 [ Homo sapiens (human) ]

    Gene ID: 349136, updated on 5-Mar-2024

    Summary

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    Official Symbol
    WDR86provided by HGNC
    Official Full Name
    WD repeat domain 86provided by HGNC
    Primary source
    HGNC:HGNC:28020
    See related
    Ensembl:ENSG00000187260 AllianceGenome:HGNC:28020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in spleen (RPKM 5.6), endometrium (RPKM 5.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    7q36.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (151368955..151410712, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (152550820..152583552, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (151078210..151107798, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:150936637-150937836 Neighboring gene uncharacterized LOC124901779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150938593-150939094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150941724-150942298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150942299-150942872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150942873-150943447 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150943448-150944021 Neighboring gene Sharpr-MPRA regulatory region 13648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18809 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150949301-150950210 Neighboring gene chondroitin polymerizing factor 2 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150953220-150953720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150953721-150954221 Neighboring gene microRNA 671 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150971756-150972555 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150974709-150975418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151000420-151001278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26857 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26858 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:151038519-151039020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26859 Neighboring gene negative regulator of ubiquitin like proteins 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151084439-151085101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151107690-151108322 Neighboring gene WDR86 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151125597-151126116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26861 Neighboring gene uncharacterized LOC124901780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26862 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151134795-151135644 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151136006-151136506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151136507-151137007 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:151137719-151138255 Neighboring gene Sharpr-MPRA regulatory region 6092 Neighboring gene microRNA 3907 Neighboring gene crystallin gamma N Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:151153164-151154036 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:151154037-151154909 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151155634-151156302 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:151157640-151158307 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:151159408-151159959 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:151161805-151162306 Neighboring gene RNA, 7SL, cytoplasmic 76, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile. Dendoncker K, et al. Proc Natl Acad Sci U S A, 2019 Jun 25. PMID 31182584, Free PMC Article
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    4. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
    5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ51355, MGC129839

    General protein information

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    Preferred Names
    WD repeat-containing protein 86

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284260.2 → NP_001271189.1  WD repeat-containing protein 86 isoform 1

      See identical proteins and their annotated locations for NP_001271189.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC005486, AC005996, AK296049, BC047921
      Consensus CDS
      CCDS64806.1
      UniProtKB/Swiss-Prot
      Q86TI4
      Related
      ENSP00000419162.2, ENST00000469830.2
      Conserved Domains (3) summary
      COG2319
      Location:3 → 234
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:4 → 241
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:61 → 95
      7WD40; WD40 repeat [structural motif]

    2. NM_001284261.2 → NP_001271190.1  WD repeat-containing protein 86 isoform 3

      See identical proteins and their annotated locations for NP_001271190.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (3) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC005486, AC005996, AK125347, BC047921
      Consensus CDS
      CCDS64805.1
      UniProtKB/TrEMBL
      A0A090N7X3
      Related
      ENSP00000417512.1, ENST00000477459.5
      Conserved Domains (3) summary
      COG2319
      Location:35 → 128
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:12 → 62
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:3 → 123
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001284262.2 → NP_001271191.1  WD repeat-containing protein 86 isoform 4

      See identical proteins and their annotated locations for NP_001271191.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC005996, BC047921, BC107125
      Consensus CDS
      CCDS75680.1
      UniProtKB/TrEMBL
      A0A0C4DGX6
      Related
      ENSP00000482209.1, ENST00000621812.2
      Conserved Domains (2) summary
      cd00200
      Location:3 → 215
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:12 → 62
      7WD40; WD40 repeat [structural motif]

    4. NM_198285.3 → NP_938026.2  WD repeat-containing protein 86 isoform 2

      See identical proteins and their annotated locations for NP_938026.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC005996, BC047921, BC107125, BI757623, BX338490, BX390499, DA267732
      Consensus CDS
      CCDS5925.2
      UniProtKB/Swiss-Prot
      B4DJF1, C9JAJ5, C9JXE3, Q3KNT1, Q6ZUS8, Q86TI4
      Related
      ENSP00000335522.7, ENST00000334493.11
      Conserved Domains (4) summary
      smart00320
      Location:5 → 43
      WD40; WD40 repeats
      COG2319
      Location:24 → 346
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:53 → 341
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:101 → 135
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      151368955..151410712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420328.1 → XP_047276284.1  WD repeat-containing protein 86 isoform X12

    2. XM_047420327.1 → XP_047276283.1  WD repeat-containing protein 86 isoform X13

    3. XM_011516151.4 → XP_011514453.1  WD repeat-containing protein 86 isoform X9

      Conserved Domains (3) summary
      COG2319
      Location:3 → 244
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:4 → 251
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:19 → 55
      7WD40; WD40 repeat [structural motif]

    4. XM_011516147.4 → XP_011514449.1  WD repeat-containing protein 86 isoform X5

      Conserved Domains (3) summary
      COG2319
      Location:3 → 244
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:4 → 251
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:19 → 55
      7WD40; WD40 repeat [structural motif]

    5. XM_011516145.4 → XP_011514447.1  WD repeat-containing protein 86 isoform X2

      Conserved Domains (3) summary
      COG2319
      Location:3 → 234
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:4 → 241
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:61 → 95
      7WD40; WD40 repeat [structural motif]

    6. XM_011516144.4 → XP_011514446.1  WD repeat-containing protein 86 isoform X1

      Conserved Domains (3) summary
      COG2319
      Location:3 → 234
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:4 → 241
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:61 → 95
      7WD40; WD40 repeat [structural motif]

    7. XM_005249990.6 → XP_005250047.1  WD repeat-containing protein 86 isoform X8

      Conserved Domains (3) summary
      COG2319
      Location:3 → 311
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:8 → 301
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:61 → 95
      7WD40; WD40 repeat [structural motif]

    8. XM_011516146.4 → XP_011514448.1  WD repeat-containing protein 86 isoform X4

      Conserved Domains (4) summary
      smart00320
      Location:5 → 43
      WD40; WD40 repeats
      COG2319
      Location:24 → 346
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:53 → 341
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:101 → 135
      7WD40; WD40 repeat [structural motif]

    9. XM_011516148.2 → XP_011514450.1  WD repeat-containing protein 86 isoform X6

      See identical proteins and their annotated locations for XP_011514450.1

      Conserved Domains (3) summary
      COG2319
      Location:35 → 113
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:12 → 62
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:3 → 113
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    10. XM_005249989.5 → XP_005250046.1  WD repeat-containing protein 86 isoform X3

      Conserved Domains (3) summary
      COG2319
      Location:3 → 244
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:4 → 251
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:19 → 55
      7WD40; WD40 repeat [structural motif]

    11. XM_011516150.2 → XP_011514452.1  WD repeat-containing protein 86 isoform X6

      See identical proteins and their annotated locations for XP_011514452.1

      Conserved Domains (3) summary
      COG2319
      Location:35 → 113
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:12 → 62
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:3 → 113
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    12. XM_006715966.4 → XP_006716029.1  WD repeat-containing protein 86 isoform X7

      Conserved Domains (3) summary
      COG2319
      Location:3 → 284
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:8 → 292
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:61 → 95
      7WD40; WD40 repeat [structural motif]

    13. XM_011516152.3 → XP_011514454.1  WD repeat-containing protein 86 isoform X10

      Conserved Domains (3) summary
      COG2319
      Location:3 → 234
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:4 → 241
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:61 → 95
      7WD40; WD40 repeat [structural motif]

    14. XM_047420326.1 → XP_047276282.1  WD repeat-containing protein 86 isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      152550820..152583552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358132.1 → XP_054214107.1  WD repeat-containing protein 86 isoform X12

    2. XM_054358129.1 → XP_054214104.1  WD repeat-containing protein 86 isoform X9

    3. XM_054358124.1 → XP_054214099.1  WD repeat-containing protein 86 isoform X5

    4. XM_054358121.1 → XP_054214096.1  WD repeat-containing protein 86 isoform X2

    5. XM_054358120.1 → XP_054214095.1  WD repeat-containing protein 86 isoform X1

    6. XM_054358128.1 → XP_054214103.1  WD repeat-containing protein 86 isoform X8

    7. XM_054358123.1 → XP_054214098.1  WD repeat-containing protein 86 isoform X4

    8. XM_054358125.1 → XP_054214100.1  WD repeat-containing protein 86 isoform X6

    9. XM_054358122.1 → XP_054214097.1  WD repeat-containing protein 86 isoform X3

    10. XM_054358126.1 → XP_054214101.1  WD repeat-containing protein 86 isoform X6

    11. XM_054358127.1 → XP_054214102.1  WD repeat-containing protein 86 isoform X7

    12. XM_054358130.1 → XP_054214105.1  WD repeat-containing protein 86 isoform X10

    13. XM_054358131.1 → XP_054214106.1  WD repeat-containing protein 86 isoform X11

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86TI4.3 GenPept UniProtKB/Swiss-Prot:Q86TI4

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