pcbp2 poly(rC) binding protein 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pcbp2provided by ZNC
Official Full Name: poly(rC) binding protein 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-563
See related: Ensembl:ENSDARG00000099039 AllianceGenome:ZFIN:ZDB-GENE-030131-563
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: PCBP3; fb36h02; zgc:55964; wu:fb36h02
Summary: Enables mRNA 3'-UTR binding activity. Predicted to be involved in regulation of RNA metabolic process and regulation of gene expression. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in intestine; nervous system; otic vesicle; somite; and tail bud. Orthologous to several human genes including PCBP2 (poly(rC) binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (252579..263759, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (252946..264126, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fj38d09.x1 (e-PCR)
- UniSTS:199258

fc86c04.y1 (e-PCR)
- UniSTS:194681

fb36h02.x1 (e-PCR)
- UniSTS:203151

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: poly(rC)-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201192.1 → NP_957486.1 poly(rC)-binding protein 2

See identical proteins and their annotated locations for NP_957486.1

Status: PROVISIONAL

Source sequence(s)

BC045508

UniProtKB/TrEMBL

Q6NYG7, Q7ZVK5

Related

ENSDARP00000134105.1, ENSDART00000165585.2

Conserved Domains (2) summary

cd00105
Location:242 → 304

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:99 → 163

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...