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    Sctr secretin receptor [ Mus musculus (house mouse) ]

    Gene ID: 319229, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Sctrprovided by MGI
    Official Full Name
    secretin receptorprovided by MGI
    Primary source
    MGI:MGI:2441720
    See related
    Ensembl:ENSMUSG00000026387 AllianceGenome:MGI:2441720
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6530402O03Rik
    Summary
    Enables secretin receptor activity. Involved in several processes, including diet induced thermogenesis; positive regulation of cAMP-mediated signaling; and water homeostasis. Predicted to be located in cytoplasmic microtubule. Predicted to be active in plasma membrane. Orthologous to human SCTR (secretin receptor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in stomach adult (RPKM 11.4), adrenal adult (RPKM 3.1) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 E2.3; 1 52.57 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (119934710..119991269)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (120006879..120063539)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 221 Neighboring gene predicted gene, 17973 Neighboring gene predicted gene, 33817 Neighboring gene predicted gene, 33764 Neighboring gene STARR-seq mESC enhancer starr_02045 Neighboring gene predicted gene, 41936 Neighboring gene transmembrane protein 37 Neighboring gene predicted gene, 41937

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Secretin receptor-deficient mice exhibit robust food anticipatory activity. Sugiyama M, et al. Neurosci Lett, 2022 Feb 16. PMID 35051436
    2. Secretin receptor-deficient mice exhibit altered circadian rhythm in wheel-running activity. Sugiyama M, et al. Neurosci Lett, 2020 Mar 23. PMID 32027952
    3. Secretin is involved in sodium conservation through the renin-angiotensin-aldosterone system. Bai J, et al. FASEB J, 2017 Apr. PMID 28082350
    4. Transmembrane peptides as unique tools to demonstrate the in vivo action of a cross-class GPCR heterocomplex. Lee LT, et al. FASEB J, 2014 Jun. PMID 24599969, Free PMC Article
    5. Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation. Glaser S, et al. Hepatology, 2010 Jul. PMID 20578263, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effects of sleep deprivation on sleep and sleep electroencephalogram in secretin-receptor knockout mice.
      Title: Effects of sleep deprivation on sleep and sleep electroencephalogram in secretin-receptor knockout mice.
    2. Loss of the Secretin Receptor Impairs Renal Bicarbonate Excretion and Aggravates Metabolic Alkalosis in Mice during Acute Base-Loading.
      Title: Loss of the Secretin Receptor Impairs Renal Bicarbonate Excretion and Aggravates Metabolic Alkalosis in Mice during Acute Base-Loading.
    3. Secretin receptor deletion in the subfornical organ attenuates the activation of excitatory neurons under dehydration.
      Title: Secretin receptor deletion in the subfornical organ attenuates the activation of excitatory neurons under dehydration.
    4. Secretin receptor-deficient mice exhibit robust food anticipatory activity.
      Title: Secretin receptor-deficient mice exhibit robust food anticipatory activity.
    5. Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.
      Title: Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.
    6. Secretin receptor-deficient mice exhibit altered circadian rhythm in wheel-running activity.
      Title: Secretin receptor-deficient mice exhibit altered circadian rhythm in wheel-running activity.
    7. High secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis.
      Title: Secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis.
    8. The involvement of secretin (SCT) and its receptor (SCTR) in angiotensin II (ANGII)-mediated osmoregulation by forming SCTR/ angiotensin II type 1 receptor (AT1R) heteromer is well established. In this study, we demonstrated that SCTR/AT1R complex can mediate ANGII-induced aldosterone secretion/release through potentiating calcium mobilization.
      Title: Role of SCTR/AT1aR heteromer in mediating ANGII-induced aldosterone secretion.
    9. Enhanced senescence levels in cholangiocytes from Mdr2(-/-) mice were reversed to normal in SR(-/-)/Mdr2(-/-) mice.
      Title: Knockout of secretin receptor reduces biliary damage and liver fibrosis in Mdr2(-/-) mice by diminishing senescence of cholangiocytes.
    10. Knockout of SCTR results in defective aldosterone biosynthesis/release and altered sensitivity of ENaCs to amiloride.
      Title: Secretin is involved in sodium conservation through the renin-angiotensin-aldosterone system.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102218

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables secretin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables secretin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables secretin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in diet induced thermogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular water homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of lipid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of appetite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of appetite IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in renal water absorption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to nutrient levels IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    secretin receptor
    Names
    SCT-R

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012322.2 → NP_001012322.2  secretin receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_001012322.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK032652, BC089355
      Consensus CDS
      CCDS48341.1
      UniProtKB/TrEMBL
      H7BX37
      Related
      ENSMUSP00000072660.5, ENSMUST00000072886.11
      Conserved Domains (2) summary
      cd15275
      Location:153 → 419
      7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
      pfam02793
      Location:77 → 140
      HRM; Hormone receptor domain

    2. NM_001311077.1 → NP_001298006.1  secretin receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001298006.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK032652, BC089355
      Consensus CDS
      CCDS78668.1
      UniProtKB/Swiss-Prot
      Q5FWI2, Q80T66
      Related
      ENSMUSP00000139932.2, ENSMUST00000189037.2
      Conserved Domains (2) summary
      pfam00002
      Location:138 → 383
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:63 → 125
      HRM; Hormone receptor domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      119934710..119991269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529684.5 → XP_006529747.1  secretin receptor isoform X1

      Conserved Domains (2) summary
      cd15275
      Location:153 → 417
      7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
      pfam02793
      Location:77 → 140
      HRM; Hormone receptor domain

    2. XM_006529686.5 → XP_006529749.1  secretin receptor isoform X2

      Conserved Domains (2) summary
      cd15275
      Location:138 → 404
      7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
      pfam02793
      Location:63 → 125
      HRM; Hormone receptor domain

    3. XM_036165671.1 → XP_036021564.1  secretin receptor isoform X6

      Conserved Domains (3) summary
      pfam02793
      Location:77 → 140
      HRM; Hormone receptor domain
      cd14964
      Location:155 → 180
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:153 → 352
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_036165670.1 → XP_036021563.1  secretin receptor isoform X6

      Conserved Domains (3) summary
      pfam02793
      Location:77 → 140
      HRM; Hormone receptor domain
      cd14964
      Location:155 → 180
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:153 → 352
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. XM_036165668.1 → XP_036021561.1  secretin receptor isoform X3

      Conserved Domains (2) summary
      cd15275
      Location:153 → 408
      7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
      pfam02793
      Location:77 → 140
      HRM; Hormone receptor domain

    6. XM_011248029.2 → XP_011246331.1  secretin receptor isoform X4

      See identical proteins and their annotated locations for XP_011246331.1

      Conserved Domains (2) summary
      cd15275
      Location:67 → 333
      7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
      pfam02793
      Location:2 → 54
      HRM; Hormone receptor domain

    7. XM_036165669.1 → XP_036021562.1  secretin receptor isoform X4

      Conserved Domains (2) summary
      cd15275
      Location:67 → 333
      7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
      pfam02793
      Location:2 → 54
      HRM; Hormone receptor domain

    8. XM_006529688.4 → XP_006529751.1  secretin receptor isoform X4

      See identical proteins and their annotated locations for XP_006529751.1

      Conserved Domains (2) summary
      cd15275
      Location:67 → 333
      7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
      pfam02793
      Location:2 → 54
      HRM; Hormone receptor domain

    9. XM_011248031.4 → XP_011246333.1  secretin receptor isoform X5

      Conserved Domains (2) summary
      cd15275
      Location:62 → 328
      7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
      cl02422
      Location:22 → 49
      HRM; Hormone receptor domain

    10. XM_030254873.2 → XP_030110733.1  secretin receptor isoform X8

      Conserved Domains (2) summary
      cd14964
      Location:53 → 75
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:46 → 281
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    11. XM_006529689.4 → XP_006529752.1  secretin receptor isoform X7

      Conserved Domains (2) summary
      cd14964
      Location:53 → 75
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:46 → 283
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    12. XM_006529690.3 → XP_006529753.1  secretin receptor isoform X9

      Conserved Domains (2) summary
      cd14964
      Location:1 → 25
      7tm_GPCRs; TM helix 3 [structural motif]
      cl28897
      Location:1 → 187
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RNA

    1. XR_004942727.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FWI2.1 GenPept UniProtKB/Swiss-Prot:Q5FWI2

    Gene LinkOut

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