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    Tiparp TCDD-inducible poly(ADP-ribose) polymerase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310467, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Tiparpprovided by RGD
    Official Full Name
    TCDD-inducible poly(ADP-ribose) polymeraseprovided by RGD
    Primary source
    RGD:1306171
    See related
    Ensembl:ENSRNOG00000011238 AllianceGenome:RGD:1306171
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RM1
    Summary
    Predicted to enable NAD+ ADP-ribosyltransferase activity; cis-regulatory region sequence-specific DNA binding activity; and protein ADP-ribosylase activity. Involved in response to 2,3,7,8-tetrachlorodibenzodioxine. Predicted to be located in nucleus. Orthologous to human TIPARP (TCDD inducible poly(ADP-ribose) polymerase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 150.5), Lung (RPKM 117.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (152063769..152090414)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (149753682..149780327)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (157316293..157342979)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene signal sequence receptor subunit 3 Neighboring gene uncharacterized LOC102554278 Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein L36A, pseudogene 11 Neighboring gene uncharacterized LOC134485623

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TCDD dysregulation of 13 AHR-target genes in rat liver. Watson JD, et al. Toxicol Appl Pharmacol, 2014 Feb 1. PMID 24355419
    2. Characterization of TCDD-inducible poly-ADP-ribose polymerase (TIPARP/ARTD14) catalytic activity. Gomez A, et al. Biochem J, 2018 Dec 11. PMID 30373764, Free PMC Article
    3. TCDD-inducible poly(ADP-ribose) polymerase: a novel response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Ma Q, et al. Biochem Biophys Res Commun, 2001 Nov 30. PMID 11716501
    4. Identification and cataloging of genes induced by long-lasting long-term potentiation in awake rats. Matsuo R, et al. J Neurochem, 2000 Jun. PMID 10820183
    5. The PDGF signaling pathway controls multiple steroid-producing lineages. Schmahl J, et al. Genes Dev, 2008 Dec 1. PMID 19056881, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD+ ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NAD+- protein-cysteine ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NAD+-protein ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within androgen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within estrogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within face morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within female gonad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to 2,3,7,8-tetrachlorodibenzodioxine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within roof of mouth development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within smooth muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein mono-ADP-ribosyltransferase TIPARP
    NP_001101149.2
    XP_038958213.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107679.3 → NP_001101149.2  protein mono-ADP-ribosyltransferase TIPARP

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6GA83, A6J5J7, D3ZMH5
      Related
      ENSRNOP00000015387.3, ENSRNOT00000015387.7
      Conserved Domains (2) summary
      cd01439
      Location:529 → 648
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      pfam02825
      Location:348 → 401
      WWE; WWE domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      152063769..152090414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102285.2 → XP_038958213.1  protein mono-ADP-ribosyltransferase TIPARP isoform X1

      UniProtKB/TrEMBL
      A0A8I6GA83, A6J5J7, D3ZMH5
      Conserved Domains (2) summary
      cd01439
      Location:529 → 648
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      pfam02825
      Location:348 → 401
      WWE; WWE domain
    Nucleotide Protein Strain
    Heading Accession and Version

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