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    Fan1 FANCD2 and FANCI associated nuclease 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309256, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Fan1provided by RGD
    Official Full Name
    FANCD2 and FANCI associated nuclease 1provided by RGD
    Primary source
    RGD:1566323
    See related
    Ensembl:ENSRNOG00000023985 AllianceGenome:RGD:1566323
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mtmr15; RGD1566323
    Summary
    Predicted to enable flap-structured DNA binding activity; nuclease activity; and ubiquitin-dependent protein binding activity. Predicted to be involved in double-strand break repair via homologous recombination; interstrand cross-link repair; and nucleotide-excision repair, DNA incision. Predicted to be located in cytosol; intercellular bridge; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in karyomegalic interstitial nephritis. Orthologous to human FAN1 (FANCD2 and FANCI associated nuclease 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 43.3), Heart (RPKM 39.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (127327098..127356807, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (117915323..117945044, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (125182117..125209772, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily M, member 1 Neighboring gene microRNA 211 Neighboring gene myotubularin related protein 10 Neighboring gene M-phase phosphoprotein 10 Neighboring gene methylmalonyl CoA epimerase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1. Wang R, et al. Science, 2014 Nov 28. PMID 25430771, Free PMC Article
    2. FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain. Pennell S, et al. Cell Rep, 2014 Jul 10. PMID 24981866, Free PMC Article
    3. Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents. Kratz K, et al. Cell, 2010 Jul 9. PMID 20603016
    4. A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Smogorzewska A, et al. Mol Cell, 2010 Jul 9. PMID 20603073, Free PMC Article
    5. Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. MacKay C, et al. Cell, 2010 Jul 9. PMID 20603015, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5'-3' exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-3' exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 5'-flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-flap endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables flap-structured DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flap-structured DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphodiesterase I activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-modified protein reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    fanconi-associated nuclease 1
    Names
    FANCD2/FANCI-associated nuclease 1
    coiled-coil domain-containing protein MTMR15
    myotubularin related protein 15
    NP_001178562.1
    XP_006229401.1
    XP_038935867.1
    XP_038935871.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191633.1 → NP_001178562.1  fanconi-associated nuclease 1

      See identical proteins and their annotated locations for NP_001178562.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      D3ZVU2
      Related
      ENSRNOP00000032711.5, ENSRNOT00000031067.7
      Conserved Domains (1) summary
      smart00990
      Location:896 → 1011
      VRR_NUC; This model contains proteins with the VRR-NUC domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      127327098..127356807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079939.2 → XP_038935867.1  fanconi-associated nuclease 1 isoform X2

      Conserved Domains (1) summary
      cd22326
      Location:376 → 965
      FAN1-like; repair nuclease FAN1

    2. XM_006229339.5 → XP_006229401.1  fanconi-associated nuclease 1 isoform X1

      See identical proteins and their annotated locations for XP_006229401.1

      UniProtKB/TrEMBL
      D3ZVU2
      Conserved Domains (1) summary
      smart00990
      Location:896 → 1011
      VRR_NUC; This model contains proteins with the VRR-NUC domain

    3. XM_039079943.2 → XP_038935871.1  fanconi-associated nuclease 1 isoform X3

      UniProtKB/TrEMBL
      A6JBL0
      Conserved Domains (1) summary
      cd22326
      Location:376 → 724
      FAN1-like; repair nuclease FAN1
    Nucleotide Protein Strain
    Heading Accession and Version

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